GLORIA

GEOMAR Library Ocean Research Information Access

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    In: Frontiers in Molecular Biosciences, Frontiers Media SA, Vol. 9 ( 2022-3-1)
    Abstract: Colorectal cancer (CRC) is the second most deadly cancer in the whole world, with the underlying mechanisms largely indistinct. Therefore, we aimed to identify significant pathways and genes involved in the initiation, formation and poor prognosis of CRC using bioinformatics methods. In this study, we compared gene expression profiles of CRC cases with those from normal colorectal tissues from three chip datasets (GSE33113, GSE23878 and GSE41328) to identify 105 differentially expressed genes (DEGs) that were common to the three datasets. Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses showed that the highest proportion of up-regulated DEGs was involved in extracellular region and cytokine-cytokine receptor interaction pathways. Integral components of membrane and bile secretion pathways were identified as containing down-regulated DEGs. 13 hub DEGs were chosen and their expression were further validated by GEPIA. Only four DEGs (ADH1C, CLCA4, CXCL8 and GUCA2A) were associated with a significantly lower overall survival after the prognosis analysis. Lower ADH1C protein level and higher CXCL8 protein level were verified by immunohistochemical staining and western blot in clinical CRC and normal colorectal tissues. In conclusion, our study indicated that the extracellular tumor microenvironment and bile metabolism pathways play critical roles in the formation and progression of CRC. Furthermore, we confirmed ADH1C being down-regulated in CRC and reported ADH1C as a prognostic predictor for the first time.
    Type of Medium: Online Resource
    ISSN: 2296-889X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2814330-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Online Resource
    Online Resource
    David Publishing Company ; 2015
    In:  Journal of Agricultural Science and Technology B Vol. 5, No. 9 ( 2015-09-28)
    In: Journal of Agricultural Science and Technology B, David Publishing Company, Vol. 5, No. 9 ( 2015-09-28)
    Type of Medium: Online Resource
    ISSN: 2161-6264 , 2161-6264
    URL: Issue
    Language: Unknown
    Publisher: David Publishing Company
    Publication Date: 2015
    detail.hit.zdb_id: 2687741-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Cell and Developmental Biology Vol. 9 ( 2021-4-1)
    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 9 ( 2021-4-1)
    Abstract: Inflammation is involved in cardiac remodeling. In response to pathological stimuli, activated cardiac fibroblasts (CFs) secreting inflammatory cytokines and chemokines play an important role in monocyte/macrophage recruitment. However, the precise mechanism of CF-mediated inflammatory response in hypertension-induced cardiac remodeling remains unclear. In the present study, we investigated the role of transcription factor Krüppel-like factor 15 (KLF15) in this process. We found that KLF15 expression decreased while chemokine CXCL1 and its receptor CXCR2 expression increased in the hearts of angiotensin II (Ang II)-infused mice. Compared to the wild-type mice, KLF15 knockout (KO) mice aggravated Ang II-induced cardiac hypertrophy and fibrosis. Deficiency of KLF15 promoted macrophage accumulation, increase of CXCL1 and CXCR2 expression, and mTOR, ERK1/2, NF-κB-p65 signaling activation in the hearts. Mechanistically, Ang II dose- dependently decreased KLF15 expression and increased CXCL1 secretion from cardiac fibroblasts but not cardiac myoblasts. Loss- or gain-of-function studies have shown that KLF15 negatively regulated CXCL1 expression through its transactivation domain (TAD). Intriguingly, the adenovirus-mediated full length of KLF15—but not KLF15 with TAD deletion overexpression—markedly prevented pathological change in Ang II-infused mice. Notably, the administration of CXCR2 inhibitor SB265610 reversed KLF15 knockout-mediated aggravation of cardiac dysfunction, remodeling, and inflammation induced by Ang II. In conclusion, our study identifies that KLF15 in cardiac fibroblasts negatively regulates CXCL1/CXCR2 axis-mediated inflammatory response and subsequent cardiac remodeling in hypertension.
    Type of Medium: Online Resource
    ISSN: 2296-634X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2737824-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Online Resource
    Online Resource
    Canadian Center of Science and Education ; 2020
    In:  Journal of Molecular Biology Research Vol. 10, No. 1 ( 2020-09-08), p. 82-
    In: Journal of Molecular Biology Research, Canadian Center of Science and Education, Vol. 10, No. 1 ( 2020-09-08), p. 82-
    Abstract: Apteronotus albifrons has its cloacal aperture located in the front of the body and on the back of the lower jaw. A. albifrons possess a pair of testes attached on the mesentery below its liver on the back of the abdominal cavity. In the early days of development, the testes are in translucent elongated thin strips in nude colour. As they develop, the testes will grow thicker and become white or creamy white in color. The rear end of the testes will split whereas the front end will merge to form the vas deferens which is connected to the external environment through the cloacal aperture. Testes of A. albifrons are lobular. There are six stages in its development. At 6 months of age, the testis structure shows clear medium with primary spermatocytes and abundant spermatogonia, suggesting that development is into the stageⅡ. At 8 months of age, testes in male A. albifrons are in the shape of a thin rod in white with blood vessels in presence. Germ cells consist of spermatogonia, primary spermatocytes and spermatocytes, indicating stageⅢ development. At 11 months of age, testes in male A. albifrons grow fuller and are in creamy white with apparent blood vessels present. Primary spermatocytes, secondary spermatocytes, spermatids and a small amount of sperms are president, indicating stageⅣ of development. At 15 months of age, testes in male A. albifrons swells and consist of a large amount of sperms, reaching full maturity. This is the stageⅥof development, after which is the stage featured by testes after spermiation.
    Type of Medium: Online Resource
    ISSN: 1925-4318 , 1925-430X
    Language: Unknown
    Publisher: Canadian Center of Science and Education
    Publication Date: 2020
    detail.hit.zdb_id: 2649718-9
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Online Resource
    Online Resource
    American Astronomical Society ; 2023
    In:  The Astrophysical Journal Vol. 949, No. 2 ( 2023-06-01), p. 115-
    In: The Astrophysical Journal, American Astronomical Society, Vol. 949, No. 2 ( 2023-06-01), p. 115-
    Abstract: We discover three new weak pulse components in two known pulsars, one in PSR J0304+1932 and two in PSR J1518+4904. These components are emitted about halfway between the main emission beam and the interpulse beam (beam from the opposite pole). They are separated from their main pulse peak by 99° ± 3° for J0304+1932 and 123.°6 ± 0.°7 (leading) and 93° ± 0.°4 (trailing) for J1518+4904. Their peak-intensity ratios to main pulses are ∼ 0.06% for J0304+1932 and ∼0.17% and ∼0.83% for J1518+4904. We also analyzed the flux fluctuations and profile variations of the emissions for the two pulsars. The results show correlations between the weak pulses and their main pulses, indicating that these emissions come from the same pole. We estimated the emission altitude of these weak pulses and derived a height of about half of the pulsar’s light-cylinder radius. These pulse components are a unique sample of high-altitude emissions from pulsars, and challenge the current pulsar emission models.
    Type of Medium: Online Resource
    ISSN: 0004-637X , 1538-4357
    RVK:
    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2023
    detail.hit.zdb_id: 2207648-7
    detail.hit.zdb_id: 1473835-1
    SSG: 16,12
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2021
    In:  IEEE Transactions on Intelligent Transportation Systems Vol. 22, No. 1 ( 2021-1), p. 36-49
    In: IEEE Transactions on Intelligent Transportation Systems, Institute of Electrical and Electronics Engineers (IEEE), Vol. 22, No. 1 ( 2021-1), p. 36-49
    Type of Medium: Online Resource
    ISSN: 1524-9050 , 1558-0016
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2021
    detail.hit.zdb_id: 2034300-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    Online Resource
    Online Resource
    IOP Publishing ; 2018
    In:  IOP Conference Series: Earth and Environmental Science Vol. 113 ( 2018-02), p. 012160-
    In: IOP Conference Series: Earth and Environmental Science, IOP Publishing, Vol. 113 ( 2018-02), p. 012160-
    Type of Medium: Online Resource
    ISSN: 1755-1307 , 1755-1315
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2018
    detail.hit.zdb_id: 2434538-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 8
    Online Resource
    Online Resource
    IOP Publishing ; 2020
    In:  IOP Conference Series: Earth and Environmental Science Vol. 555, No. 1 ( 2020-08-01), p. 012043-
    In: IOP Conference Series: Earth and Environmental Science, IOP Publishing, Vol. 555, No. 1 ( 2020-08-01), p. 012043-
    Abstract: The project team selected eight typical buses (CNG, LNG, gasoline- electric hybrid, gas-electricity hybrid) at different emission stages in the built-up area of Tangshan City to test the emission of gaseous pollutants and particulate matter under actual road conditions, systematically evaluated, analyzed and compared the test results, and established the VSPbin emission rate database and emission factor list of typical urban buses in built-up areas based on the actual travelling characteristics of Tangshan. In this study, four cycles of acceleration, constant speed, deceleration and idle speed were selected to analyze the travelling cycle of buses in Tangshan. The results showed that the proportion of acceleration was higher, while deceleration also had a higher proportion; The area of bus travelling was mainly in the urban area, and the travelling cycles were relatively complicated, so there were frequent acceleration and deceleration during the travelling process. For the buses, with the raising of emission standards and the use of hybrid technology, the emissions of CO 2 and NO x from the buses at National IV were decreased by 13% and 53.5% respectively compared with those from the buses of the same tonnage at National III; The emissions of CO 2 and NO x from the nature gas-electric hybrid buses at National V were reduced by 20% and 18.8% respectively compared with those from the nature gas-fueled buses of the same tonnage at National V.
    Type of Medium: Online Resource
    ISSN: 1755-1307 , 1755-1315
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 2434538-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 9
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2023
    In:  IEEE Transactions on Dependable and Secure Computing
    In: IEEE Transactions on Dependable and Secure Computing, Institute of Electrical and Electronics Engineers (IEEE)
    Type of Medium: Online Resource
    ISSN: 1545-5971 , 1941-0018 , 2160-9209
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2023
    detail.hit.zdb_id: 2162420-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 10
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 2528, No. 1 ( 2023-07-01), p. 012019-
    Abstract: This paper focuses on the offline electric heating regeneration technology of DPF (Diesel Particulate Filter). Based on the actual operating conditions of the airport passenger elevator, the pressure drop changes before and after the offline regeneration of DPF, the passive regeneration process during the vehicle operation, and the capture efficiency of PM and PN after the offline regeneration of DPF are studied. The DPF pressure drop increases with the operation time because of the extremely low efficiency of passive regeneration before offline regeneration, and the initial pressure drop after regeneration is slightly higher than that of the fresh carrier due to the existence of ash. When the exhaust temperature reaches 420°C, the DPF passive regeneration rate is higher than the capture rate, and the DPF pressure drop drops rapidly when the passenger elevator continues to run. The mass fraction of fine particulate matter is more than 0.02μm in the cold start stage, while the mass fraction of fine particulate matter is more than 0.02μm in the hot start stage.
    Type of Medium: Online Resource
    ISSN: 1742-6588 , 1742-6596
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 2166409-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...