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  • 1
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Genetics Vol. 13 ( 2022-12-6)
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 13 ( 2022-12-6)
    Abstract: Familial hypercholesterolemia (FH) is a common, inherited disease characterized by high levels of low-density lipoprotein Cholesterol (LDL-C) from birth. Any diseases associated with increased LDL-C levels including atherosclerotic cardiovascular diseases (ASCVDs) would be expected to be overrepresented among FH patients. There are several clinical scoring systems aiming to diagnose FH, however; most individuals who meet the clinical criteria for a FH diagnosis do not have a mutation causing FH. In this review, we aim to summarize the literature on the risk for the various forms of ASCVD in subjects with a proven FH-mutation (FH+). We searched for studies on FH+ and cardiovascular diseases and also included our and other groups published papers on FH + on a wide range of cardiovascular and other diseases of the heart and vessels. FH + patients are at a markedly increased risk of a broad range of ASCVD. Acute myocardial infarction (AMI) is the most common in absolute numbers, but also aortic valve stenosis is by far associated with the highest excess risk. Per thousand patients, we observed 3.6 incident AMI per year compared to 1.9 incident aortic valve stenosis, however, standardized incidence ratio (SIR) for incident AMI was 2.3 compared to 7.9 for incident aortic valve stenosis. Further, occurrence of ischemic stroke seems not to be associated with increased risk in FH+. Clinicians should be aware of the excess risk of almost all kind of ASCVD in FH+, and the neutral risk of stroke need to be studied further in FH + patients.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606823-0
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  • 2
    In: Acta Dermato-Venereologica, Medical Journals Sweden AB, Vol. 103 ( 2023-04-04), p. adv4403-
    Abstract: Little is known about if and how nevi and pigmentation are associated with melanoma-specific mortality. However, increased melanoma awareness in people with lighter pigmentation and many nevi may result in earlier diagnosis of thinner less-lethal tumors. The aim of this study was to investigate associations between nevus count (asymmetrical 〉  5 mm and small symmetrical), pigmentary characteristics (hair colour, eye colour, skin colour, freckling, pigmentary score), and melanoma-specific mortality in subjects with melanomas 〉  1 mm. Data from the Norwegian Women and Cancer cohort, established in 1991, with complete follow-up of melanoma patients until 2018 through the Cancer Registry of Norway, were used to estimate hazard ratios with 95% confidence intervals for the associations between nevus count, pigmentary characteristics, and melanoma-specific mortality, stratified by tumor thickness using Cox regression. Estimated hazard ratios consistently indicated a higher risk of melanoma death for those with darker vs lighter pigmentary characteristics in patients with tumors 〉  1.0–2.0 mm and 〉  2.0 mm thick (e.g. pigmentary score hazard ratio 1.25, 95% confidence interval (0.74–2.13)). Among women with melanomas 〉  1.0 mm thick, lighter pigmentation and asymmetrical nevi may be associated with lower melanoma-specific mortality, suggesting that factors that increase the risk of melanoma may also be associated with decreased risk of death from melanoma.
    Type of Medium: Online Resource
    ISSN: 1651-2057 , 0001-5555
    RVK:
    Language: Unknown
    Publisher: Medical Journals Sweden AB
    Publication Date: 2023
    detail.hit.zdb_id: 1492617-9
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  • 3
    Online Resource
    Online Resource
    Medical Journals Sweden AB ; 2022
    In:  Journal of Rehabilitation Medicine Vol. 54 ( 2022-07-13), p. jrm00300-
    In: Journal of Rehabilitation Medicine, Medical Journals Sweden AB, Vol. 54 ( 2022-07-13), p. jrm00300-
    Abstract: Objective: To describe and compare patients with neck and back pain treated by physiotherapists in primary healthcare (PHC) and in departments for physical medicine and rehabilitation in specialist healthcare (SHC) in Norway.Design: Cross-sectional study using data from the FYSIOPRIM database in PHC and the Norwegian Neck and Back Registry in SHC. Neck and back pain patients in the period 2014–18 aged ≥ 18 years were included. Demographics, lifestyle and clinical factors were investigated.Results: A total of 8,125 patients were included: 584 in PHC and 7,541 in SHC. Mean age was 47.1 and 45.5 years, respectively, with more females in PHC (72% vs 56%). Low levels of education and physical activity, high workload and receiving social benefits were associated with treatment in SHC. Treatment in SHC was most common from 3 to 12 months’ pain duration. Higher pain intensity and lower health-related quality of life were found in patients treated in SHC, no differences were found for psychological distress.Conclusion: This is the first study comparing register data in patients with neck and back pain treated in PHC and SHC. Differences were found in pain and health-related quality of life, but levels of psychological distress were similar between patients treated in PHC and those treated in SHC.
    Type of Medium: Online Resource
    ISSN: 1651-2081
    Language: Unknown
    Publisher: Medical Journals Sweden AB
    Publication Date: 2022
    detail.hit.zdb_id: 2054931-3
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  • 4
    Online Resource
    Online Resource
    Norwegian University of Science and Technology (NTNU) Library ; 2022
    In:  Norsk Epidemiologi Vol. 30, No. 1-2 ( 2022-10-12)
    In: Norsk Epidemiologi, Norwegian University of Science and Technology (NTNU) Library, Vol. 30, No. 1-2 ( 2022-10-12)
    Abstract: Leon A.M. Berge, Tom K. Grimsrud, Ronnie Babigumira, Nathalie C. Støer, Nita K. Shala, Marit B. Veierød and Jo S. Stenehjem: Cancer epidemiology in practice: Working notes on cancer history-based selection and censoring
    Type of Medium: Online Resource
    ISSN: 0803-2491
    Language: Unknown
    Publisher: Norwegian University of Science and Technology (NTNU) Library
    Publication Date: 2022
    detail.hit.zdb_id: 2379279-6
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  • 5
    Online Resource
    Online Resource
    Norwegian University of Science and Technology (NTNU) Library ; 2014
    In:  Norsk Epidemiologi Vol. 24, No. 1-2 ( 2014-12-29)
    In: Norsk Epidemiologi, Norwegian University of Science and Technology (NTNU) Library, Vol. 24, No. 1-2 ( 2014-12-29)
    Abstract: Objective: Examine responses given to questions addressing whether pregnancy had caused women with nausea and vomiting (NVP) or symptom-free (SF) to alter their food habits in the first trimester in order to better understand the dietary changes taking place in women with NVP.Method: Using questions featured in the Norwegian Mother and Child Cohort Study (MoBa) specifically asking participants about alterations in diet and episodes of nausea and vomiting. The final sample used included 30,072 women.Results: We found 46% with no symptoms of nausea and/or vomiting in pregnancy, whilst 54% reported both nausea and vomiting. The NVP group of women were the group most affected with changes in food consumption, having the lowest proportion reporting to eat as before pregnancy, as well as the highest proportion reporting ‘eating more’ and ‘reduced eating’. The SF group reported eating more than NVP group in one instance, that being for chocolate (SF 17.7% vs NVP 16.3%).Conclusion: We have shown a higher degree of dietary change in women with NVP compared to SF women. We also found chocolate as the only exception, with a higher proportion of SF women eating more of this food item.
    Type of Medium: Online Resource
    ISSN: 0803-2491
    Language: Unknown
    Publisher: Norwegian University of Science and Technology (NTNU) Library
    Publication Date: 2014
    detail.hit.zdb_id: 2379279-6
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