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  • 1
    Online Resource
    Online Resource
    Elastosonographic evaluation after extracorporeal shockwave treatment in plantar fasciopathy
    SRUMB - Romanian Society for Ultrasonography in Medicine and Biology ; 2019
    In:  Medical Ultrasonography Vol. 21, No. 4 ( 2019-11-24), p. 399-
    Details
    In: Medical Ultrasonography, SRUMB - Romanian Society for Ultrasonography in Medicine and Biology, Vol. 21, No. 4 ( 2019-11-24), p. 399-
    Abstract: Aim: To assess the ultrasound features in patients with plantar fasciopathy before and after extracorporeal shock waves therapy (ESWT), using conventional grey-scale imaging and both strain (SE) and shear wave (SWE) elastosonographic evaluation.Material and method: Consecutive patients of both sexes attending our outpatient’s clinic, with diagnosis of unilateral plantar fasciopathy, were enrolled. Patients were treated with 3 sessions of ESWT once a week, and underwent clinical and ultrasound evaluation at baseline and at one and three months after treatment. Roles and Maudsley score (RM), visual analog scale (VAS) and 17-Italian Foot Function Index (FFI), were used to assess pain and functional improvement.Results: Twenty patients (11 female and 9 male) were enrolled in the study. Contralateral asymptomatic healthy plantar fascia was used as a control. At baseline, SWE velocity (SWEv) showed statistically significant difference between affected 3.8 (1.5; 5.1) m/s and healthy side 4.7 (4.07; 7.04) m/s, (p=0.006); no significant difference was found for strain ratio values (p=0.656). SWEv post hoc test results showed a significant difference from baseline 3.8 (1.5-5.1) m/s and three month 5.23 (4.55-6.74) m/s follow up visit (p=0.003). Significant statistical negative correlation was found between the SWEv and VAS (p=0.001) and positive correlation between the SWEv and FFI (p=0.012).Conclusion: SWE was effective in assessing plantar fascia elasticity and its alteration in fasciopathy. Furthermore, on the basis of the correlation with pain and functional scales, this technique appears to be a useful additional technique to conventional ultrasound for monitoring the efficacy of treatment
    Type of Medium: Online Resource
    ISSN: 2066-8643 , 1844-4172
    URL: Article
    DOI: 10.11152/mu-1976
    Language: Unknown
    Publisher: SRUMB - Romanian Society for Ultrasonography in Medicine and Biology
    Publication Date: 2019
    detail.hit.zdb_id: 2529623-1
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  • 2
    Online Resource
    Online Resource
    Design of Radiation Hard Spare Units for the Orbit Corrector Dipoles of LHC
    Institute of Electrical and Electronics Engineers (IEEE) ; 2020
    In:  IEEE Transactions on Applied Superconductivity Vol. 30, No. 4 ( 2020-6), p. 1-5
    Details
    In: IEEE Transactions on Applied Superconductivity, Institute of Electrical and Electronics Engineers (IEEE), Vol. 30, No. 4 ( 2020-6), p. 1-5
    Type of Medium: Online Resource
    ISSN: 1051-8223 , 1558-2515 , 2378-7074
    URL: Journal
    URL: Article
    DOI: 10.1109/TASC.77
    DOI: 10.1109/TASC.2020.2972223
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2020
    detail.hit.zdb_id: 2025387-4
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  • 3
    Online Resource
    Online Resource
    Table_1.DOCX
    Frontiers Media SA ; 2021
    In:  Frontiers in Molecular Neuroscience Vol. 14 ( 2021-9-3)
    Details
    In: Frontiers in Molecular Neuroscience, Frontiers Media SA, Vol. 14 ( 2021-9-3)
    Abstract: The zebrafish represents a powerful model for exploring how light regulates the circadian clock due to the direct light sensitivity of its peripheral clocks, a property that is retained even in organ cultures as well as zebrafish-derived cell lines. Light-inducible expression of the per2 clock gene has been predicted to play a vital function in relaying light information to the core circadian clock mechanism in many organisms, including zebrafish. To directly test the contribution of per2 to circadian clock function in zebrafish, we have generated a loss-of-function per2 gene mutation. Our results reveal a tissue-specific role for the per2 gene in maintaining rhythmic expression of circadian clock genes, as well as clock-controlled genes, and an impact on the rhythmic behavior of intact zebrafish larvae. Furthermore, we demonstrate that disruption of the per2 gene impacts on the circadian regulation of the cell cycle in vivo . Based on these results, we hypothesize that in addition to serving as a central element of the light input pathway to the circadian clock, per2 acts as circadian regulator of tissue-specific physiological functions in zebrafish.
    Type of Medium: Online Resource
    ISSN: 1662-5099
    URL: Article
    URL: Article
    DOI: 10.3389/fnmol.2021.718387
    DOI: 10.3389/fnmol.2021.718387.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2452967-9
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  • 4
    Online Resource
    Online Resource
    Torção uterina em égua no terço médio gestacional: relato de caso.
    Scientific Electronic Archives ; 2022
    In:  Scientific Electronic Archives Vol. 15, No. 10 ( 2022-10-01)
    Details
    In: Scientific Electronic Archives, Scientific Electronic Archives, Vol. 15, No. 10 ( 2022-10-01)
    Abstract: Torções uterinas compõe o quadro das principais emergências obstétricas na espécie equina. A rotação de um dos cornos uterinos ou do útero ao longo do eixo longitudinal pode variar de leve a grave, conforme o grau de rotação e comprometimento dos tecidos envolvidos. O prognóstico é considerado desfavorável, quando há comprometimento da homeostase do paciente, dificuldade no diagnóstico preciso e ausência de intervenção cirúrgica imediata. O presente relato tem como objetivo a descrição de um caso de torção uterina em uma égua, no terço médio gestacional, atendida a campo no município de Sinop, estado de Mato Grosso, Brasil. A clínica observada foi de dor abdominal aguda, taquicardia, taquipinéia, ausência de motilidade gastrointestinal, edema vulvar e eversão de mucosa vaginal. A palpação retal evidenciou a impossibilidade de palpação uterina, a ultrassonografia identificou apenas a presença do ovário direito. A evolução clínica do quadro procedeu de forma negativa resultando em óbito materno e fetal.                                                                               
    Type of Medium: Online Resource
    ISSN: 2316-9281
    URL: Article
    DOI: 10.36560/151020221606
    Language: Unknown
    Publisher: Scientific Electronic Archives
    Publication Date: 2022
    detail.hit.zdb_id: 2771824-4
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  • 5
    Online Resource
    Online Resource
    Effects of somatostatin analog SOM230 on cell proliferation, apoptosis, and catecholamine levels in cultured pheochromocytoma cells
    Bioscientifica ; 2008
    In:  Journal of Molecular Endocrinology Vol. 40, No. 6 ( 2008-04-1), p. 263-271
    Details
    In: Journal of Molecular Endocrinology, Bioscientifica, Vol. 40, No. 6 ( 2008-04-1), p. 263-271
    Abstract: Surgery is the primary therapy for pheochromocytoma (PHEO), a catecholamine-producing tumor. Benign and malignant PHEO could develop recurrences, and the intraoperative risk of recurrent PHEO is an important unresolved issue. Non-surgical treatments of PHEO recurrence would therefore better prepare patients for reintervention as well as provide them with palliative management. We investigated the effects of the new somatostatin analog (pasireotide) SOM230 versus octreotide (OCT) in primary PHEO cell cultures (Pheo-c). Pheo-c from six benign surgical samples were set up and characterized by immunocytochemistry. Real-time PCR, using both PHEO tissues and Pheo-c, showed different levels of somatostatin receptor 1–5 mRNA expression. Cells treated with various doses of OCT or SOM230 for 48 and 72 h were analyzed to assess their effects on cell proliferation and apoptosis and catecholamine levels. Even if reduction of cell viability was observed in Pheo-c treated for 48 h with either OCT or SOM230 and this effect increased after 72 h, a more significant inhibition of cell growth as well as a significantly higher induction of apoptosis was seen in Pheo-c treated with SOM230 versus OCT. In particular, apoptosis in Pheo-c was detected after 48 h and was associated with increased expression and activation of caspase-3 and cleaved poly(ADP-ribose) polymerase. OCT 10 −6  M and SOM230 10 −7  M significantly reduced catecholamine levels. Our results indicate that while both OCT and SOM230 modulate cell growth and apoptosis and catecholamine levels in Pheo-c through specific receptors, SOM230 is more effective. This improves our knowledge on the mechanism of SOM230 action in PHEO and supports a possible therapeutic use in benign PHEO recurrence.
    Type of Medium: Online Resource
    ISSN: 0952-5041 , 1479-6813
    URL: Article
    DOI: 10.1677/JME-08-0012
    Language: Unknown
    Publisher: Bioscientifica
    Publication Date: 2008
    detail.hit.zdb_id: 1478171-2
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  • 6
    Online Resource
    Online Resource
    Table_2.DOCX
    Frontiers Media SA ; 2022
    In:  Frontiers in Pediatrics Vol. 10 ( 2022-9-6)
    Details
    In: Frontiers in Pediatrics, Frontiers Media SA, Vol. 10 ( 2022-9-6)
    Abstract: Short/branched-chain acyl-CoA dehydrogenase deficiency (SBCADD) is an inherited disorder of L-isoleucine metabolism due to mutations in the ACADSB gene. The role of current diagnostic biomarkers [i.e., blood 2-methylbutyrylcarnitine (C5) and urine 2-methylbutyrylglycine (2MBG)] in patient monitoring and the effects of proposed treatments remain uncertain as follow-data are lacking. This study presents first systematic longitudinal biochemical assessment in SBCADD patients. Methods A retrospective, observational single-center study was conducted on newborns born between 2017 and 2020 and suspected with SBCADD. Biochemical, molecular, clinical and dietary data collected upon NBS recall and during the subsequent follow-up were recorded. Results All enrolled subjects ( n = 10) received adequate protein intake and L-carnitine supplementation. Nine subjects were diagnosed with SBCADD. During the follow-up [median: 20.5 (4–40) months] no patient developed symptoms related to SBCADD. No patient normalized serum C5 and urine 2MBG values. In 7/9 SBCADD patients mean serum C5 values decreased or stabilized compared to their first serum C5 value. A major increase in serum C5 values was observed in two patients after L-carnitine discontinuation and during intercurrent illness, respectively. Urine 2MBG values showed moderate intra-patient variability. Discussion The relatively stable serum C5 values observed during L-carnitine supplementation together with C5 increase occurring upon L-carnitine discontinuation/intercurrent illness may support the value of serum C5 as a monitoring biomarker and the benefit of this treatment in SBCADD patients. The role of urine 2MBG in patient monitoring remains uncertain. As all patients were asymptomatic, no association between biochemical parameters and clinical phenotype could be investigated in this study.
    Type of Medium: Online Resource
    ISSN: 2296-2360
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fped.2022.895921
    DOI: 10.3389/fped.2022.895921.s001
    DOI: 10.3389/fped.2022.895921.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2711999-3
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