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  • 1
    Online Resource
    Online Resource
    Role of plant secondary metabolites as potential antimalarial drugs
    AkiNik Publications ; 2022
    In:  International Journal of Mosquito Research Vol. 9, No. 3 ( 2022-05-01), p. 13-22
    Details
    In: International Journal of Mosquito Research, AkiNik Publications, Vol. 9, No. 3 ( 2022-05-01), p. 13-22
    Type of Medium: Online Resource
    ISSN: 2348-7941 , 2348-5906
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.22271/23487941.2022.v9.i3.a
    DOI: 10.22271/23487941
    DOI: 10.22271/23487941.2022.v9.i3a.609
    Language: Unknown
    Publisher: AkiNik Publications
    Publication Date: 2022
    detail.hit.zdb_id: 2763847-9
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  • 2
    Online Resource
    Online Resource
    In-silico designing of an inhibitor against mTOR FRB domain: Therapeutic implications against breast cancer
    Journal of Experimental Biology and Agricultural Sciences ; 2022
    In:  Journal of Experimental Biology and Agricultural Sciences Vol. 10, No. 5 ( 2022-10-31), p. 1016-1023
    Details
    In: Journal of Experimental Biology and Agricultural Sciences, Journal of Experimental Biology and Agricultural Sciences, Vol. 10, No. 5 ( 2022-10-31), p. 1016-1023
    Abstract: Worldwide breast cancer causes significant fatalities in women. The effective therapeutic solution for treating the disease is using new and probable antagonistic biologically available ligands as anticancer drugs. To identify a successful therapeutic approach, the scientific community is now interested in creating novel ligands that in the future may be used as anticancer drugs. The mechanistic target of rapamycin (mTOR) is a protein kinase connected to several processes governing immunity, metabolism, cell development, and survival. The proliferation and metastasis of tumors have both been linked to the activation of the mTOR pathway. Female breast cancer represents about 15.3% of all new cancer cases in the U.S. alone and is frequently diagnosed among women aged 55 to 69 years. Given that the P13K/AKT/mTOR pathway is one of the most often activated in cancer, much attention has been paid to its resistance as a novel oncological treatment approach. mTOR/FRB Domain’s recruitment cleft as, well as substrate recruitment mechanism, was targeted using a structural-based approach. A series of selective inhibitory small molecules have been designed and screened for the best inhibiting target binding triad of the FRB Domain with better ADME and no detectable toxic effects.
    Type of Medium: Online Resource
    ISSN: 2320-8694
    URL: Issue
    URL: Article
    DOI: 10.18006/2022.10(5)
    DOI: 10.18006/2022.10(5).1016.1023
    Language: Unknown
    Publisher: Journal of Experimental Biology and Agricultural Sciences
    Publication Date: 2022
    detail.hit.zdb_id: 2715507-9
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  • 3
    Online Resource
    Online Resource
    An overview on Monkeypox, Current Paradigms and Advances in its Vaccination, Treatment and Clinical Management: Trends, Scope, Promise and Challenges
    Journal of Pure and Applied Microbiology ; 2022
    In:  Journal of Pure and Applied Microbiology Vol. 16, No. suppl 1 ( 2022-12-30), p. 3000-3012
    Details
    In: Journal of Pure and Applied Microbiology, Journal of Pure and Applied Microbiology, Vol. 16, No. suppl 1 ( 2022-12-30), p. 3000-3012
    Abstract: Monkeypox virus is an orthopoxvirus sharing the common genus with variola and vaccinia virus. Most of the monkeypox (MPX) cases had been reported from the central and west African region (the main endemic areas) prior to 2022 but there was a sudden outbreak in May, 2022 disseminating the infections to thousands of people even in non-endemic countries, posing a global public health emergency. MPX was considered a rae and neglected disease, however the 2022 MPX outbreaks in multiple countries attracted attention of worldwide researchers to pace up for carrying out researches on various aspects of MPXV including attempts to design and develop diagnostics, vaccines, drugs and therapeutics counteract MPX. Apart from being a zoonotic disease, the current outbreaks highlighted rapid human-to-human transmission of MPXV, besides the reverse zoonosis has also been documented with recent first report of human-to-dog transmission, urging a call for the importance of one health approach. Atypical and unusual disease manifestations as well asymptomatic MPXV infections have also been observed during 2022 MPX outbreak. The affected patients typically develop a rash resulting in a mild disease followed by recovery with some supportive care and use of antivirals such as tecovirimat, cidofovir and brincidofovir in severe disease cases. Modified vaccinia Ankara (MVA) vaccine with an excellent safety profile has been recommended to patients with higher risk exposure and immunocompromised individuals. Moreover, another vaccine the replication-competent vaccine (ACAM2000) could be a suitable alternative to MVA’s non-availability to some selective immunocompetent individuals. Current review highlights the salient aspects of management and treatment of monkeypox along with underlying promises in terms of therapeutics and a variety of challenges posed due to current global public health emergency situation to counteract MPX.
    Type of Medium: Online Resource
    ISSN: 0973-7510 , 2581-690X
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.22207/JPAM.16.SPL1
    DOI: 10.22207/JPAM
    DOI: 10.22207/JPAM.16.SPL1.21
    Language: Unknown
    Publisher: Journal of Pure and Applied Microbiology
    Publication Date: 2022
    detail.hit.zdb_id: 2853403-7
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  • 4
    Online Resource
    Online Resource
    Computational Docking Study of the Phytochemical Constituent, Silybin (Silybum marianum) against SARS-CoV-2 Omicron Variant Spike Glycoprotein: An In-silico Approach
    Journal of Pure and Applied Microbiology ; 2023
    In:  Journal of Pure and Applied Microbiology Vol. 17, No. 1 ( 2023-3-5), p. 385-394
    Details
    In: Journal of Pure and Applied Microbiology, Journal of Pure and Applied Microbiology, Vol. 17, No. 1 ( 2023-3-5), p. 385-394
    Abstract: SARS-CoV-2 is continually evolving with the emergence of new variants with increased viral pathogenicity. The emergence of heavily mutated Omicron (B.1.1.529) with spike protein mutations are known to mediate its higher transmissibility and immune escape that has brought newer challenges for global public health to contain SARS-CoV-2 infection. One has to come up with a therapeutic strategy against the virus so as to effectively contain the infection and spread. Natural phytochemicals are being considered a significant source of bioactive compounds possessing an antiviral therapeutic potential. Being a promising anticancer and chemo-preventive agent, Silybin holds a significant potential to be used as a therapeutic. In the present study, molecular docking of Silybin with Omicron spike protein (7QNW) was carried out. Molecular docking results showed greater stability of Silybin in the active site of the Omicron spike protein with suitable binding mode of interactions. The study reveals that Silybin has the potential to block the host ACE2 receptor-viral spike protein binding; thereby inhibiting the viral entry to human cells. Therefore, Silybin may be further developed as a medication with the ability to effectively combat SARS-CoV-2 Omicron.
    Type of Medium: Online Resource
    ISSN: 0973-7510 , 2581-690X
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.22207/JPAM.17.1
    DOI: 10.22207/JPAM
    DOI: 10.22207/JPAM.17.1.29
    Language: Unknown
    Publisher: Journal of Pure and Applied Microbiology
    Publication Date: 2023
    detail.hit.zdb_id: 2853403-7
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  • 5
    Online Resource
    Online Resource
    Acceptance and Attitudes of North Indian Population Towards COVID-19 Vaccines
    Saran Publications ; 2022
    In:  International Journal of Zoological Investigations Vol. 08, No. 02 ( 2022), p. 444-450
    Details
    In: International Journal of Zoological Investigations, Saran Publications, Vol. 08, No. 02 ( 2022), p. 444-450
    Abstract: Coronavirus disease 2019 (COVID-19) is a pandemic which had a severe impact on all aspects of life all over the world. Vaccines are the most significant and effective interventions which are capable enough to reduce the high burden of diseases around the globe. An effective vaccine is the most anticipated resolution. The hesitancy in general public towards vaccination is a major problem for Government and health authorities as well. In this study, evaluation of health issues faced after vaccination, preferred vaccines, role of health authorities in preventing the COVID 19 disease spread, and kind of hesitancy for vaccination are discussed. Primary random data is collected from 370 individuals from north India about the COVID vaccine. The descriptive and infernal statistical tools are implemented to analyze the data using SPSS software. According to responses from the respondents’ vaccine from other countries are more effective as compared to the Indian one. Covishield vaccine was the choice of maximum respondents as compared to others. The preferencesfor the vaccination and side effects did not have any relationship whether a particular respondent got the vaccine or not. Youngers are less likely to accept COVID vaccine.
    Type of Medium: Online Resource
    ISSN: 2454-3055
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.33745/ijzi.2022
    DOI: 10.33745/ijzi
    DOI: 10.33745/ijzi.2022.v08i02.054
    Language: Unknown
    Publisher: Saran Publications
    Publication Date: 2022
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  • 6
    Online Resource
    Online Resource
    In-silico designing of a potent ligand molecule against PTEN (Phosphatase and tensin homolog) implicated in Breast Cancer
    Journal of Experimental Biology and Agricultural Sciences ; 2022
    In:  Journal of Experimental Biology and Agricultural Sciences Vol. 10, No. 4 ( 2022-08-30), p. 840-845
    Details
    In: Journal of Experimental Biology and Agricultural Sciences, Journal of Experimental Biology and Agricultural Sciences, Vol. 10, No. 4 ( 2022-08-30), p. 840-845
    Abstract: Breast cancer has been attributed to be the second most common malignancy in females worldwide after skin cancer associated with a significantly high mortality rate. Tumor suppressor genes have an indispensable role in maintaining genomic integrity as well as cell cycle regulation. Phosphatase and tensin homolog deleted on chromosome ten (PTEN) is one of the most frequently mutated human tumor suppressor genes, implicated in cell growth, survival, and suppressing tumor formation. As the tumor progresses to more advanced stages, genetic alterations tend to increase one such alteration is the mutation of the PTEN gene which is linked to programmed cell death and maintenance of cell cycle regulation. There is a syndrome known as Cowden syndrome associated with a high risk of breast cancer which is a result of an outcome of germline mutations in the PTEN gene. Loss of PTEN activity, either at the protein or genomic level, has been related to many primary and metastatic malignancies including breast cancer. This study focuses on developing a potential bioavailable ligand inhibitory molecule for PTEN, using a computer-aided drug design approach (CADD). A library of developed ligands consisting of 50 potential molecules was screened to find a potential candidate to be used for second generation drug development. Among them, LIG28 was adjudged as the most effective and potential PTEN inhibitor given its maximum binding affinity of ΔG -5.96Kcal/mole with a lower RMSD value. Carmer’s Rule of toxicity further revealed the compatibility and non-toxicity of the molecule. These observations underscore the importance of PTEN as a target in the development of tumorigenesis and the prognosis of breast cancer.
    Type of Medium: Online Resource
    ISSN: 2320-8694
    URL: Issue
    URL: Article
    DOI: 10.18006/2022.10(4)
    DOI: 10.18006/2022.10(4).840.845
    Language: Unknown
    Publisher: Journal of Experimental Biology and Agricultural Sciences
    Publication Date: 2022
    detail.hit.zdb_id: 2715507-9
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  • 7
    Online Resource
    Online Resource
    Targeting Omicron (B.1.1.529) SARS CoV-2 spike protein with selected phytochemicals: an in-silico approach for identification of potential drug
    Journal of Experimental Biology and Agricultural Sciences ; 2022
    In:  Journal of Experimental Biology and Agricultural Sciences Vol. 10, No. 2 ( 2022-04-30), p. 396-404
    Details
    In: Journal of Experimental Biology and Agricultural Sciences, Journal of Experimental Biology and Agricultural Sciences, Vol. 10, No. 2 ( 2022-04-30), p. 396-404
    Abstract: Severe acute respiratory syndrome coronavirus -2 (S ARS-CoV-2) emerging variants particularly those of concern contain numerous mutations that influence the behavior and transmissibility of the virus and could adversely affect the efficacies of existing coronavirus disease 2019 (COVID-19) vaccines and immunotherapies. The emerging SARS-CoV-2 variants have resulted in different waves of the pandemic within the ongoing COVID-19 pandemic. On 26 November 2021 World Health Organization designated omicron (B.1.1.529) as the fifth variant of concern which was first reported from South Africa on November 24, 2021, and thereafter rapidly spread across the globe owing to its very high transmission rates along with impeding efficacies of existing vaccines and immunotherapies. Omicron contains more than 50 mutations with many mutations (26-32) in spike protein that might be associated with high transmissibility. Natural compounds particularly phytochemicals have been used since ancient times for the treatment of different diseases, and owing to their potent anti-viral properties have also been explored recently against COVID-19. In the present study, molecular docking of nine phytochemicals (Oleocanthal, Tangeritin, Coumarin, Malvidin, Glycitein, Piceatannol, Pinosylnin, Daidzein, and Naringenin) with omicron spike protein (7QNW (electron microscopy, resolution 2.40 Å) was done. The docking study revealed that selected ligands interact with the receptor with binding energy in the range of -6.2 to-7.0 kcal/mol. Pinosylnin showed the highest binding energy of -7.0 kcal/mol which may be used as potential ligands against omicron spike protein. Based on the docking studies, it was suggested that these phytochemicals are potential molecules to be tested against omicron SARS-CoV-2 and can be used to develop effective antiviral drugs.
    Type of Medium: Online Resource
    ISSN: 2320-8694
    URL: Issue
    URL: Article
    DOI: 10.18006/2022.10(2)
    DOI: 10.18006/2022.10(2).396.404
    Language: Unknown
    Publisher: Journal of Experimental Biology and Agricultural Sciences
    Publication Date: 2022
    detail.hit.zdb_id: 2715507-9
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  • 8
    Online Resource
    Online Resource
    Tecovirimat as a Potential Bioavailable inhibitor against MPXVgp158 Established through Molecular Dynamic Simulations and Docking Studies
    Journal of Pure and Applied Microbiology ; 2022
    In:  Journal of Pure and Applied Microbiology Vol. 16, No. suppl 1 ( 2022-12-30), p. 3168-3178
    Details
    In: Journal of Pure and Applied Microbiology, Journal of Pure and Applied Microbiology, Vol. 16, No. suppl 1 ( 2022-12-30), p. 3168-3178
    Abstract: Monkeypox is a zoonotic viral infection caused by monkeypox virus which belongs to the Poxviridae family of genus Orthopoxvirus. Usually, the virus transmission happens when the individual comes in contact with the infected person through body fluids, animal lesions, respiratory droplets or through virus contaminated materials. Clinical presentation of the monkeypox has shown significant resemblance to that of smallpox and chickenpox, belonging to the same orthopoxvirus genus but were eradicated during 1980s globally. Monkeypox may lead to a range of medical complications including clinical symptoms like fever, rashes, headaches, back pain, myodynia and swollen lymph nodes. As far as the treatment modalities are concerned, the antiviral therapeutic agents developed for the smallpox treatment, were also permitted to be used for the monkeypox treatment. However, there is no proven treatment for human monkeypox. In the current study, we have focused on designing of a best probable ligand against the target MPXVgp158 (Monkeypox virus protein). Since Tecovirimat is an FDA approved compound known as an antipoxviral drug, the study aimed to develop a Monkeypox virus protein MPXVgp158 inhibitor which is bioavailable and biocompatible as well through drug designing using computational tools. Molecular docking (MD) analysis displayed Tecovirimat with lesser binding energy, higher non-bonded interaction capability, and more stability against MPXVgp158, with efficient binding mode of interactions. Hence, Tecovirimat was adjudged to be the potential candidate against MPXVgp158 inhibition.
    Type of Medium: Online Resource
    ISSN: 0973-7510 , 2581-690X
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.22207/JPAM.16.SPL1
    DOI: 10.22207/JPAM
    DOI: 10.22207/JPAM.16.SPL1.13
    Language: Unknown
    Publisher: Journal of Pure and Applied Microbiology
    Publication Date: 2022
    detail.hit.zdb_id: 2853403-7
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