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  • 1
    Online Resource
    Online Resource
    International Union of Crystallography (IUCr) ; 2016
    In:  Acta Crystallographica Section A Foundations and Advances Vol. 72, No. a1 ( 2016-08-28), p. s254-s254
    In: Acta Crystallographica Section A Foundations and Advances, International Union of Crystallography (IUCr), Vol. 72, No. a1 ( 2016-08-28), p. s254-s254
    Type of Medium: Online Resource
    ISSN: 2053-2733
    Language: Unknown
    Publisher: International Union of Crystallography (IUCr)
    Publication Date: 2016
    detail.hit.zdb_id: 2020844-3
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  • 2
    In: Frontiers in Psychiatry, Frontiers Media SA, Vol. 13 ( 2022-10-6)
    Abstract: Lack of motivation is widely acknowledged as a significant factor in treatment discontinuity and poor treatment outcomes in eating disorders. Treatment adherence is lower in internet-based treatment. The current study aimed to assess the relationship between treatment motivation and treatment outcomes in an internet-based therapist-guided intervention for Binge Eating Disorder (BED). Method Adults ( N = 153) with mild to moderate symptoms of BED participated in a 10-session internet-based treatment program. Baseline and between-session scores of “Readiness to change” and “Belief in change” were used to predict treatment completion and eating disorder symptom reduction (EDE-Q Global, BED-Q, and weekly number of binge eating episodes) at post-treatment. Results Baseline treatment motivation could not predict treatment completion or symptom reduction. Early measures of treatment motivation (regression slope from sessions 1–5) significantly predicted both treatment completion and post-treatment symptom reduction. “Belief in change” was the strongest predictor for completing treatment (OR = 2.18, 95%-CI: 1.06, 4.46) and reducing symptoms (EDE-Q Global: B = −0.53, p = 0.001; number of weekly binge eating episodes: B = 0.81, p & lt; 0.01). Discussion The results indicated that patients entering online treatment for BED feel highly motivated. However, baseline treatment motivation could not significantly predict treatment completion, which contradicts previous research. The significant predictive ability of early measures of treatment motivation supports the clinical relevance of monitoring the development of early changes to tailor and optimize individual patient care. Further research is needed to examine treatment motivation in regard to internet-based treatment for BED with more validated measures.
    Type of Medium: Online Resource
    ISSN: 1664-0640
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564218-2
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  • 3
    In: Frontiers in Psychiatry, Frontiers Media SA, Vol. 13 ( 2022-11-4)
    Abstract: Online treatment for binge eating disorder (BED) is an easily available option for treatment compared to most standard treatment procedures. However, little is known about how motivation types characterize this population and how these impact treatment adherence and effect in an online setting. Therefore, we aimed to investigate a sample of written motivation statements from BED patients, to learn more about how treatment and online treatment in particular, presents in this population. Methods Using self-determination theory in a mixed methods context, we investigated which types of motivation were prevalent in our sample, how this was connected with patient sentiment, and how these constructs influence treatment and adherence. Results Contrary to what most current literature suggests, we found that in our sample ( n = 148), motivation type was not connected with treatment outcome. We did find a strong association between sentiment scores and motivation types, indicating the model is apt at detecting effects. We found that when comparing an adult and young adult population, they did not differ in motivation type and the treatment was equally effective in young adults and adults. In the sentiment scores there was a difference between sentiment score and adherence in the young adult group, as the more positive the young adults were, the less likely they were to complete the program. Discussion Because motivation type does not influence online treatment to the same degree as it would in face-to-face treatment it indicates that the typical barriers to treatment may be less crucial in an online setting. This should be considered during intake; as less motivated patients may be able to adhere better to online treatment, because the latter imposes fewer barriers of the kind that only strong motivation can overcome. The fact that motivation type and sentiment score of the written texts are strongly associated, indicate a potential for automated models to detect motivation based on sentiment.
    Type of Medium: Online Resource
    ISSN: 1664-0640
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564218-2
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  • 4
    Online Resource
    Online Resource
    Frontiers Media SA ; 2024
    In:  Frontiers in Virtual Reality Vol. 5 ( 2024-6-13)
    In: Frontiers in Virtual Reality, Frontiers Media SA, Vol. 5 ( 2024-6-13)
    Abstract: A large proportion of individuals with anxiety-related disorders refrain from seeking treatment. This may be because traditional exposure treatments induce anxiety. However, advances in exposure using virtual reality technology may encourage more individuals to seek treatment. Furthermore, using biomarkers with VR-based exposure may enable clinicians to assess anxiety levels objectively and collect data in a naturalistic setting. Methods: Here, we conduct a systematic review of the literature on the use of biomarkers in VR-based exposure treatment for anxiety. Twenty-seven studies were included, with a total of 1046 participants. Results We found that heart rate was the only biomarker that tentatively could identify changes within (75% of instances) and between sessions (60% of instances). The levels of synchrony between the findings for overall biomarkers and the results from questionnaires showed inconclusive results. Regarding the levels of synchrony between the findings for particular biomarkers and the results from questionnaires, only skin conductance level was highly synchronous for differences between groups (87% of instances). Conclusion Based on the present review, biomarkers cannot yet be used reliably to distinguish differences in self-reported symptoms of anxiety in VR-based exposure treatments.
    Type of Medium: Online Resource
    ISSN: 2673-4192
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 3017831-9
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  • 5
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2021
    In:  IEEE Access Vol. 9 ( 2021), p. 107873-107883
    In: IEEE Access, Institute of Electrical and Electronics Engineers (IEEE), Vol. 9 ( 2021), p. 107873-107883
    Type of Medium: Online Resource
    ISSN: 2169-3536
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2021
    detail.hit.zdb_id: 2687964-5
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  • 6
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2023-1-6)
    Abstract: Pulmonary arterial hypertension (PAH) is a disease characterized by elevated pulmonary vascular resistance and pulmonary artery pressure. Mortality remains high in severe cases despite significant advances in management and pharmacotherapy. Since currently approved PAH therapies are unable to significantly reverse pathological vessel remodeling, novel disease-modifying, targeted therapeutics are needed. Pathogenetically, PAH is characterized by vessel wall cell dysfunction with consecutive remodeling of the pulmonary vasculature and the right heart. Transcription factors (TFs) regulate the process of transcribing DNA into RNA and, in the pulmonary circulation, control the response of pulmonary vascular cells to macro- and microenvironmental stimuli. Often, TFs form complex protein interaction networks with other TFs or co-factors to allow for fine-tuning of gene expression. Therefore, identification of the underlying molecular mechanisms of TF (dys-)function is essential to develop tailored modulation strategies in PAH. This current review provides a compendium-style overview of TFs and TF complexes associated with PAH pathogenesis and highlights their potential as targets for vasculoregenerative or reverse remodeling therapies.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2781496-8
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  • 7
    Online Resource
    Online Resource
    Association for the Advancement of Artificial Intelligence (AAAI) ; 2023
    In:  Proceedings of the AAAI Conference on Artificial Intelligence Vol. 37, No. 10 ( 2023-06-26), p. 12305-12312
    In: Proceedings of the AAAI Conference on Artificial Intelligence, Association for the Advancement of Artificial Intelligence (AAAI), Vol. 37, No. 10 ( 2023-06-26), p. 12305-12312
    Abstract: Methods to identify cause-effect relationships currently mostly assume the variables to be scalar random variables. However, in many fields the objects of interest are vectors or groups of scalar variables. We present a new constraint-based non-parametric approach for inferring the causal relationship between two vector-valued random variables from observational data. Our method employs sparsity estimates of directed and undirected graphs and is based on two new principles for groupwise causal reasoning that we justify theoretically in Pearl's graphical model-based causality framework. Our theoretical considerations are complemented by two new causal discovery algorithms for causal interactions between two random vectors which find the correct causal direction reliably in simulations even if interactions are nonlinear. We evaluate our methods empirically and compare them to other state-of-the-art techniques.
    Type of Medium: Online Resource
    ISSN: 2374-3468 , 2159-5399
    Language: Unknown
    Publisher: Association for the Advancement of Artificial Intelligence (AAAI)
    Publication Date: 2023
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  • 8
    In: Environmental Research Letters, IOP Publishing, Vol. 17, No. 4 ( 2022-04-01), p. 044013-
    Abstract: Ecosystems are projected to face extreme high temperatures more frequently in the near future. Various biotic coping strategies exist to prevent heat stress. Controlled experiments have recently provided evidence for continued transpiration in woody plants during high air temperatures, even when photosynthesis is inhibited. Such a decoupling of photosynthesis and transpiration would represent an effective strategy (‘known as leaf or canopy cooling’) to prevent lethal leaf temperatures. At the ecosystem scale, continued transpiration might dampen the development and propagation of heat extremes despite further desiccating soils. However, at the ecosystem scale, evidence for the occurrence of this decoupling is still limited. Here, we aim to investigate this mechanism using eddy-covariance data of thirteen woody ecosystems located in Australia and a causal graph discovery algorithm. Working at half-hourly time resolution, we find evidence for a decoupling of photosynthesis and transpiration in four ecosystems which can be classified as Mediterranean woodlands. The decoupling occurred at air temperatures above 35 ∘ C. At the nine other investigated woody sites, we found that vegetation CO 2 exchange remained coupled to transpiration at the observed high air temperatures. Ecosystem characteristics suggest that the canopy energy balance plays a crucial role in determining the occurrence of a decoupling. Our results highlight the value of causal-inference approaches for the analysis of complex physiological processes. With regard to projected increasing temperatures and especially extreme events in future climates, further vegetation types might be pushed to threatening canopy temperatures. Our findings suggest that the coupling of leaf-level photosynthesis and stomatal conductance, common in land surface schemes, may need be re-examined when applied to high-temperature events.
    Type of Medium: Online Resource
    ISSN: 1748-9326
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 2255379-4
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  • 9
    Online Resource
    Online Resource
    IOP Publishing ; 2015
    In:  Physiological Measurement Vol. 36, No. 4 ( 2015-04-01), p. 813-825
    In: Physiological Measurement, IOP Publishing, Vol. 36, No. 4 ( 2015-04-01), p. 813-825
    Type of Medium: Online Resource
    ISSN: 0967-3334 , 1361-6579
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2015
    detail.hit.zdb_id: 2002076-4
    SSG: 11
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  • 10
    Online Resource
    Online Resource
    American Meteorological Society ; 2016
    In:  Journal of Climate Vol. 29, No. 11 ( 2016-06-01), p. 4069-4081
    In: Journal of Climate, American Meteorological Society, Vol. 29, No. 11 ( 2016-06-01), p. 4069-4081
    Abstract: In recent years, the Northern Hemisphere midlatitudes have suffered from severe winters like the extreme 2012/13 winter in the eastern United States. These cold spells were linked to a meandering upper-tropospheric jet stream pattern and a negative Arctic Oscillation index (AO). However, the nature of the drivers behind these circulation patterns remains controversial. Various studies have proposed different mechanisms related to changes in the Arctic, most of them related to a reduction in sea ice concentrations or increasing Eurasian snow cover. Here, a novel type of time series analysis, called causal effect networks (CEN), based on graphical models is introduced to assess causal relationships and their time delays between different processes. The effect of different Arctic actors on winter circulation on weekly to monthly time scales is studied, and robust network patterns are found. Barents and Kara sea ice concentrations are detected to be important external drivers of the midlatitude circulation, influencing winter AO via tropospheric mechanisms and through processes involving the stratosphere. Eurasia snow cover is also detected to have a causal effect on sea level pressure in Asia, but its exact role on AO remains unclear. The CEN approach presented in this study overcomes some difficulties in interpreting correlation analyses, complements model experiments for testing hypotheses involving teleconnections, and can be used to assess their validity. The findings confirm that sea ice concentrations in autumn in the Barents and Kara Seas are an important driver of winter circulation in the midlatitudes.
    Type of Medium: Online Resource
    ISSN: 0894-8755 , 1520-0442
    RVK:
    Language: Unknown
    Publisher: American Meteorological Society
    Publication Date: 2016
    detail.hit.zdb_id: 246750-1
    detail.hit.zdb_id: 2021723-7
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