In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 170, No. 4 ( 2014-04), p. 507-517
Abstract:
To assess the individuals' thyroid volume changes after the mandatory nationwide iodine fortification (IF) program in two Danish areas with different iodine intake at baseline (Copenhagen, mild iodine deficiency (ID) and Aalborg, moderate ID). Design A longitudinal population-based study (DanThyr). Methods We examined 2465 adults before (1997) and after (2008) the Danish IF of salt (2000). Ultrasonography was carried out by the same sonographers using the same equipment, after controlling performances. Participants treated for thyroid disease were excluded from analyses. Results Overall, median thyroid volume had increased in Copenhagen (11.8–12.2 ml, P =0.001) and decreased in Aalborg, although not significantly (13.3–13.1 ml, P =0.07) during the 11 years of follow-up. In both regions, there was an age-related trend in individual changes in thyroid volume from baseline to follow-up; thyroid volume increased in women 〈 40 years of age and decreased in women 〉 40 years of age. In a multivariate regression model, higher age at entry was a predictor ( P 〈 0.05) for thyroid volume decrease 〉 20% during the follow-up period (women aged 40–45 years: odds ratio (OR) 4.3 (95% CI, 2.2–8.2); women aged 60–65 years: 5.8 (2.9–11.6)) and individuals of higher age were also less likely to have an increase in thyroid volume (women aged 40–45 years: OR 0.2 (0.1–0.3); women aged 60–65: OR 0.3 (0.2–0.4)). Conclusions Age-dependent differences in thyroid volume and enlargement had leveled out after the Danish iodization program. Thus, the previously observed increase in thyroid volume with age may have been caused by ID.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2014
detail.hit.zdb_id:
1485160-X
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