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  • 1
    Online Resource
    Online Resource
    DataSheet_1.zip
    Frontiers Media SA ; 2022
    In:  Frontiers in Marine Science Vol. 9 ( 2022-11-30)
    Details
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 9 ( 2022-11-30)
    Abstract: Historically considered to be a single cosmopolitan species, the so called Octopus vulgaris species complex (OVSC) is now recognized to be a group of (at least) six cryptic species: O. americanus (in the west Atlantic), O. vulgaris (in the northeast Atlantic and Mediterranean Sea), O. aff . vulgaris (in the region of South Africa), O. tetricus (southeastern Oceania), O. sinensis (northwestern Pacific), and O. djinda (western Australia). The potentially different environmental preferences of this highly cryptic species complex may result in distinct consequences under future environmental conditions. Methods The present study employed species distribution models (SDM) using MaxEnt to investigate potential changes in habitat suitability and geographical distribution of the OVSC in the future ( i.e. , 2050, and 2100), across four representative concentration pathway scenarios (RCP-2.6, 4.5, 6.0, and 8.5, CMIP5). Results Differential responses were observed in the OVSC species analyzed. Specifically, O. vulgaris and O. tetricus exhibited a severe loss in distribution across their predicted range; O. americanus exhibited projected extirpation close to the equator, with limited expansion towards the poles; O. aff . vulgaris was projected to lose half of its current distribution; O. sinensis exhibited moderate losses, with projected increases in northern areas; and finally, O. djinda exhibited limited losses to its distribution. Except for O. sinensis , increasing RCP severity exacerbated changes in mean habitat suitability and projected distribution gains and losses. Discussion Ultimately, this study provides information on the potential biogeographical effects of marine climate change on a key worldwide ecological and economic resource to further disentangle the effects over each OVSC species, with the goal of assisting toward the sustainable management of octopus species at the global scale.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    URL: Article
    URL: Article
    DOI: 10.3389/fmars.2022.1018766
    DOI: 10.3389/fmars.2022.1018766.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2757748-X
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  • 2
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    A qualidade de vida da criança com doença crónica em idade escolar – uma revisão integrativa da literatura
    Lepidus Tecnologia ; 2022
    In:  VITTALLE - Revista de Ciências da Saúde Vol. 34, No. 3 ( 2022-12-22), p. 43-55
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    In: VITTALLE - Revista de Ciências da Saúde, Lepidus Tecnologia, Vol. 34, No. 3 ( 2022-12-22), p. 43-55
    Abstract: O diagnóstico de doença crónica na infância é um dos fatores com maior impacto na qualidade de vida da criança e sua família. A Qualidade de Vida Relacionada com a Saúde é influenciada por múltiplos fatores e a sua avaliação representa um dos indicadores mais importantes para determinar, planear, implementar e avaliar a intervenção dos profissionais de saúde nesta área. O objetivo deste estudo foi sistematizar o conhecimento científico atual sobre o impacto da doença crónica na qualidade de vida da criança entre os seis e os doze anos de idade. Foi realizada uma revisão integrativa de literatura. Pesquisa realizada entre 2016 e 2021 nas bases de dados CINAHL e MEDLINE, através dos descritores child* OR pediatric* AND chronic disease AND activities of daily living OR quality of life OR leisure activities OR emotions OR child welfare OR adaptation, psychological, obtendo-se uma amostra final de oito artigos.Saúde e atividade física; Sentimentos, Amigos/ Relações interpessoais de apoio social e Ambiente escolar e aprendizagem, representam as dimensões mais afetadas pela doença crónica, na criança e sua família.O conhecimento sobre as principais dimensões afetadas na criança/família pela doença crónica, é essencial para que os profissionais de saúde possam intervir de forma dirigida, minimizando o seu impacto e potenciando a qualidade de vida.
    Type of Medium: Online Resource
    ISSN: 2177-7853 , 1413-3563
    URL: Article
    DOI: 10.14295/vittalle.v34i3.14548
    Language: Unknown
    Publisher: Lepidus Tecnologia
    Publication Date: 2022
    detail.hit.zdb_id: 2647742-7
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  • 3
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    Online Resource
    Reconsidering the role of blood-brain barrier in Alzheimer’s disease: From delivery to target
    Frontiers Media SA ; 2023
    In:  Frontiers in Aging Neuroscience Vol. 15 ( 2023-2-16)
    Details
    In: Frontiers in Aging Neuroscience, Frontiers Media SA, Vol. 15 ( 2023-2-16)
    Abstract: The existence of a selective blood-brain barrier (BBB) and neurovascular coupling are two unique central nervous system vasculature features that result in an intimate relationship between neurons, glia, and blood vessels. This leads to a significant pathophysiological overlap between neurodegenerative and cerebrovascular diseases. Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease whose pathogenesis is still to be unveiled but has mostly been explored under the light of the amyloid-cascade hypothesis. Either as a trigger, bystander, or consequence of neurodegeneration, vascular dysfunction is an early component of the pathological conundrum of AD. The anatomical and functional substrate of this neurovascular degeneration is the BBB, a dynamic and semi-permeable interface between blood and the central nervous system that has consistently been shown to be defective. Several molecular and genetic changes have been demonstrated to mediate vascular dysfunction and BBB disruption in AD. The isoform ε4 of Apolipoprotein E is at the same time the strongest genetic risk factor for AD and a known promoter of BBB dysfunction. Low-density lipoprotein receptor–related protein 1 (LRP-1), P-glycoprotein, and receptor for advanced glycation end products (RAGE) are examples of BBB transporters implicated in its pathogenesis due to their role in the trafficking of amyloid-β. This disease is currently devoid of strategies that change the natural course of this burdening illness. This unsuccess may partly be explained by our misunderstanding of the disease pathogenesis and our inability to develop drugs that are effectively delivered to the brain. BBB may represent a therapeutic opportunity as a target itself or as a therapeutic vehicle. In this review, we aim to explore the role of BBB in the pathogenesis of AD including the genetic background and detail how it can be targeted in future therapeutic research.
    Type of Medium: Online Resource
    ISSN: 1663-4365
    URL: Article
    DOI: 10.3389/fnagi.2023.1102809
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2558898-9
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