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  • 1
    Online Resource
    Online Resource
    Clinical guidelines. Crohn’s disease (К50), adults
    Russian Association of Coloproctology ; 2023
    In:  Koloproktologia Vol. 22, No. 3 ( 2023-09-21), p. 10-49
    Details
    In: Koloproktologia, Russian Association of Coloproctology, Vol. 22, No. 3 ( 2023-09-21), p. 10-49
    Abstract: .
    Type of Medium: Online Resource
    ISSN: 2686-7303 , 2073-7556
    URL: Journal
    URL: Article
    DOI: 10.33878/2073-7556
    DOI: 10.33878/2073-7556-2023-22-3-10-49
    Language: Unknown
    Publisher: Russian Association of Coloproctology
    Publication Date: 2023
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  • 2
    Online Resource
    Online Resource
    Efficiency of new technologies in endovideosurgical treatment of liver echinococcosis
    Volgograd State Medical University ; 2023
    In:  Journal of Volgograd State Medical University Vol. 20, No. 1 ( 2023-04-23), p. 81-87
    Details
    In: Journal of Volgograd State Medical University, Volgograd State Medical University, Vol. 20, No. 1 ( 2023-04-23), p. 81-87
    Abstract: Introduction: Surgical operations remain the main and most effective option for the treatment of liver echinococcosis. With the development and mastering of the method, laparoscopic operations are being used more and more widely. New technologies aimed at improving treatment outcomes are being developed and implemented in laparoscopic surgical methods. The purpose of the study is to present and evaluate the results of treatment of operated patients with liver echinococcosis using new technologies. Materials and methods: The results of treatment of 19 patients (9/47.4 % men, 10/52.6 % women) with liver echinococcosis, who were treated with organ-sparing laparoscopic resection techniques using new technologies in the surgical department No. M.A. Podgorbunsky. Results: There was no statistically significant advantage in dissection rate among the methods used (p = 0.74). In the group of patients with the applied hemostatic matrix Floseal, the time of hemostasis was significantly less than in the group without using the method (p = 0.001). In the group of patients with the improved laparoscopic Pringle maneuver, the blood loss was significantly less than in the group without using the technique (p = 0.00008). Findings: A new patented improved method of temporary hemostasis in laparoscopic resection interventions on the liver in the study proved its effectiveness. The use of the Floseal hemostatic matrix made it possible to reduce the time of hemostasis, and, accordingly, reduce the duration of the operation and reduce intraoperative blood loss in general. The laparoscopic method of surgical intervention using the above technologies is effective and safe in the treatment of medium-sized echinococcal liver cysts.
    Type of Medium: Online Resource
    ISSN: 1994-9499 , 1994-9480
    URL: Article
    DOI: 10.19163/1994-9480-2023-20-1-81-87
    Language: Unknown
    Publisher: Volgograd State Medical University
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    Options for Two-Stage Extensive Liver Resections in the Surgical Treatment of Advanced Liver Echinococcosis
    VSMU N.N. Burdenko ; 2023
    In:  Journal of Experimental and Clinical Surgery Vol. 16, No. 2 ( 2023-07-23), p. 140-149
    Details
    In: Journal of Experimental and Clinical Surgery, VSMU N.N. Burdenko, Vol. 16, No. 2 ( 2023-07-23), p. 140-149
    Abstract: Introduction. The major and effective option for the treatment of liver echinococcosis are surgical operations. To choose a type of surgical intervention in a common form of liver echinococcosis under suspected deficit in the functional reserves of the organ and developing post-resection liver failure remains challenging.The aim of the study is to present and analyze the effectiveness of two-stage extensive resection interventions in patients with advanced liver echinococcosis.Materials and methods. The study included clinical findings of 24 patients with advanced liver echinococcosis (9/37.5% men, 15/62.5% women) who underwent surgical treatment in Surgical Department №2, Kuzbass Clinical Emergency Hospital named after M. A. Podgorbunsky " (Kemerovo). The use of a two-stage major resection protocol was the criterion for inclusion in the study. Stage I was aimed to achieve vicarious hypertrophy of the contralateral lobe using various techniques to stop blood flow along the right branch of the portal vein. A two-stage protocol for extensive resection intervention was applied due to insufficient functional liver reserves and the small volume of the potential remnant; this resulted in the inability to safely use a single-stage extensive resection due to the predicted developing post-resection liver failure and a likely lethal outcome.Results and discussions. The applied surgical stage approaches for prevention of post-resection liver failure are effective due to the following parameters: CT volumetry (p0.05), residual concentration of indocyanine green at the 15th minute (p0.05), statistical model value (p0, 05). The level of effectiveness of the above technique is comparable with the laparotomic ligation of the right branch of the portal vein; however, the laparoscopic option is less traumatic, which can significantly reduce postoperative hospital stay (p0.05). In addition, there were no specific and nonspecific complications registered in case of the laparoscopic option.Conclusion. Two-stage extensive resection interventions for advanced liver echinococcosis are effective and sufficiently safe when operations are performed in specialized hepatological centers using a comprehensive protocol for preoperative examination. They can be recommended in case of the initial significant deficit in the volume of the potential liver remnant and functional reserves of the organ.
    Type of Medium: Online Resource
    ISSN: 2409-143X , 2070-478X
    URL: Article
    DOI: 10.18499/2070-478X-2023-16-2-140-149
    Language: Unknown
    Publisher: VSMU N.N. Burdenko
    Publication Date: 2023
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  • 4
    Online Resource
    Online Resource
    СПЕКТР ОБ'ЄМНИХ ХВИЛЬ ЗСУВУ У РЕГУЛЯРНО-ШАРУВАТОМУ ПРОСТОРІ
    Open International University of Human Developmеnt Ukraine ; 2022
    In:  Інфокомунікаційні та комп’ютерні технології Vol. 1, No. 03 ( 2022-08-04), p. 102-114
    Details
    In: Інфокомунікаційні та комп’ютерні технології, Open International University of Human Developmеnt Ukraine, Vol. 1, No. 03 ( 2022-08-04), p. 102-114
    Abstract: Дано постановку та розв'язано задачу про спектр і форми колівань об'ємних пружних хвиль у регулярно - шаруватому середовищі. Отримано дисперсійні співвідношення, які дозволяють повторення хвильових полів з довільним значенням періоду структури. Проведено порівняння спектрів дисперсійних кривих об'ємних і нормальних хвиль у регулярно – шаруватій пластині. Отримані дисперсійні співвідношення аналізувалися також чисельно, а результати наведено у вигляді графіків. Побудовано моди коливань для широкого спектру дисперсійних кривих.
    Type of Medium: Online Resource
    ISSN: 2788-5518 , 2788-5518
    URL: Article
    DOI: 10.36994/2788-5518-2022-01-03-07
    Language: Unknown
    Publisher: Open International University of Human Developmеnt Ukraine
    Publication Date: 2022
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  • 5
    Online Resource
    Online Resource
    Modern approaches to the technical aspects of split-skin grafting
    VSMU N.N. Burdenko ; 2018
    In:  Vestnik of Experimental and Clinical Surgery Vol. 11, No. 1 ( 2018-04-08), p. 59-69
    Details
    In: Vestnik of Experimental and Clinical Surgery, VSMU N.N. Burdenko, Vol. 11, No. 1 ( 2018-04-08), p. 59-69
    Abstract: Split-skin grafting takes the leading place when closing extensive soft tissue defects. Such defects can be the result of both an acute process (pyoinflammatory soft tissue diseases, surgical interventions) and chronic disorders in the skin and underlying tissues (trophic ulcers of venous and arterial genesis, fistulas, decubitus, complications of the diabetic foot syndrome). The main criterion for assessing the result of split-skin grafting is the percentage of engraftment of the skin graft. There are several classifications that characterize the degree of closure of the recipient wound (Petrova VI, Rysmana BV, Gostishcheva VK). According to most authors, the successful outcome of split-skin grafting depends on several groups of factors. Systemic factors include the content of the total blood protein, hemoglobin, which should not be below acceptable standards. To the local - the readiness of the recipient wound to skin plasty. Microcirculation in the recipient bed plays an important role. The opinions of the researchers about the bacterial contamination of the wound and its effect on the processes of engrafting the flap are opposite. Some believe that a good engraftment of an autodermotransplant is possible even in the presence of a wounded pathogenic microflora in the wound. In modern works the negative influence of microorganisms on the results of split-skin grafting has been proved. Moreover, the upper limit of bacterial contamination of wounds is determined, the excess of which inevitably leads to unsatisfactory results of the transplantation of the skin. The method of postoperative donor wound management is a separate issue in plastic and reconstructive surgery. The review examines the criteria for the readiness of a wound for split-skin grafting, various types of preparation of the wound bed for plastic closure, surgical techniques for performing split-skin grafting, and options for closing the donor wound.  
    Type of Medium: Online Resource
    ISSN: 2409-143X , 2070-478X
    URL: Article
    DOI: 10.18499/2070-478X-2018-11-1-59-69
    Language: Unknown
    Publisher: VSMU N.N. Burdenko
    Publication Date: 2018
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  • 6
    Online Resource
    Online Resource
    EFFICACY OF ONE-STAGE AND TWO-STAGE EXTENSIVE SURGICAL RESECTIONS IN LIVER ECHINOCOCCOSIS
    Ulyanovsk State University ; 2023
    In:  Ulyanovsk Medico-biological Journal , No. 2 ( 2023-07-03), p. 62-75
    Details
    In: Ulyanovsk Medico-biological Journal, Ulyanovsk State University, , No. 2 ( 2023-07-03), p. 62-75
    Abstract: Surgery is the main effective way to treat liver echinococcosis. The problem of choosing a surgical technique for treating liver echinococcosis under impaired liver functional reserve and development of post- hepatectomy liver failure remains relevant. The aim of the study is to analyze the effectiveness of extensive surgical resections while treating patients with liver echinococcosis. Materials and Methods. The article presents the results of surgical treatment of 85 patients with liver echinococcosis from 2006 to 2022. All patient underwent extensive liver resection: 61 patients (71.8 %) were operated on according to one-stage extensive surgical resection protocol; 24 patients (28.2 %) were operated on according to two-stage extensive surgical resection protocol. Results. The applied surgical step-by-step methods for prevention of post-resection liver failure were effective in 24 patients (100 %), Group 2. Three deaths (3.5 %) were recorded in the total mass of the trial patients. Progressive post-resection liver failure was the cause of deaths. After the introduction of a new examination protocol into clinical practice, the authors observed no deaths after extensive surgery resections because of the development of post-resection liver failure. Moreover, no relapses were observed after extensive surgery resections. Conclusion. Extensive surgical resections in patients with liver echinococcosis are effective and sufficiently safe when performed in specialized hepatological centers using an in-depth preoperative protocol. Two-stage surgical resections can be recommended in case of initial significant deficit in the volume of the future liver remnant and functional organ reserves.
    Type of Medium: Online Resource
    ISSN: 2687-1637 , 2227-1848
    URL: Issue
    URL: Article
    DOI: 10.34014/2227-1848-2023-2
    DOI: 10.34014/2227-1848-2023-2-62-75
    Language: Unknown
    Publisher: Ulyanovsk State University
    Publication Date: 2023
    detail.hit.zdb_id: 2938582-9
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  • 7
    Online Resource
    Online Resource
    Composition of oropharyngeal microbiota in patients with COVID-19 of different pneumonia severity
    Consilium Medicum ; 2022
    In:  Terapevticheskii arkhiv Vol. 94, No. 8 ( 2022-10-12), p. 963-972
    Details
    In: Terapevticheskii arkhiv, Consilium Medicum, Vol. 94, No. 8 ( 2022-10-12), p. 963-972
    Abstract: Aim. To identify features of the taxonomic composition of the oropharyngeal microbiota of COVID-19 patients with different disease severity. Materials and methods. The study group included 156 patients hospitalized with confirmed diagnosis of COVID-19 in the clinical medical center of Yevdokimov Moscow State University of Medicine and Dentistry between April and June 2021. There were 77 patients with mild pneumonia according to CT (CT1) and 79 patients with moderate to severe pneumonia (CT2 and CT3). Oropharyngeal swabs were taken when the patient was admitted to the hospital. Total DNA was isolated from the samples, then V3V4 regions of the 16s rRNA gene were amplified, followed by sequencing using Illumina HiSeq 2500 platform. DADA2 algorithm was used to obtain amplicon sequence variants (ASV). Results. When comparing the microbial composition of the oropharynx of the patients with different forms of pneumonia, we have identified ASVs associated with the development of both mild and severe pneumonia outside hospital treatment. Based on the results obtained, ASVs associated with a lower degree of lung damage belong predominantly to the class of Gram-negative Firmicutes (Negativicutes), to various classes of Proteobacteria, as well as to the order Fusobacteria. In turn, ASVs associated with a greater degree of lung damage belong predominantly to Gram-positive classes of Firmicutes Bacilli and Clostridia. While being hospitalized, patients with severe pneumonia demonstrated negative disease dynamics during treatment significantly more often. Conclusion. We have observed differences in the taxonomic composition of the oropharyngeal microbiota in patients with different forms of pneumonia developed outside hospital treatment against COVID-19. Such differences might be due to the presumed barrier function of the oropharyngeal microbiota, which reduces the risk of virus titer increase.
    Type of Medium: Online Resource
    ISSN: 2309-5342 , 0040-3660
    URL: Article
    DOI: 10.26442/00403660.2022.08.201780
    Language: Unknown
    Publisher: Consilium Medicum
    Publication Date: 2022
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  • 8
    Online Resource
    Online Resource
    The Effectiveness of Surgical Techniques in Performing Extensive Liver Resections for Echinococcosis
    Belgorod National Research University, Russia ; 2023
    In:  Актуальные проблемы медицины Vol. 46, No. 1 ( 2023), p. 100-108
    Details
    In: Актуальные проблемы медицины, Belgorod National Research University, Russia, Vol. 46, No. 1 ( 2023), p. 100-108
    Type of Medium: Online Resource
    ISSN: 2687-0940
    URL: Article
    DOI: 10.52575/2687-0940-2023-46-1-100-108
    Language: Unknown
    Publisher: Belgorod National Research University, Russia
    Publication Date: 2023
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  • 9
    Online Resource
    Online Resource
    THE ROLE OF RISK ASSESSMENT IN RESECTION SURGERY FOR LIVER ECHINOCOCCOSIS
    Volgograd State Medical University ; 2022
    In:  Journal of Volgograd State Medical University Vol. 19, No. 2 ( 2022-02-15), p. 85-91
    Details
    In: Journal of Volgograd State Medical University, Volgograd State Medical University, Vol. 19, No. 2 ( 2022-02-15), p. 85-91
    Abstract: Resume: Introduction. Echinococcosis of the Liver with subtotal organ damage remains an urgent surgical problem. The development of surgical technologies does not stand still. In the modern scientific community, more and more publications appear that speak of good treatment results with the staged application of various surgical technologies and their combination in various options. The purpose of the study is to present and evaluate the results of treatment of operated patients with liver echinococcosis using a new diagnostic and treatment protocoL for surgicaL treatment. Materials and methods. The results of treatment of 10 patients [4 men (40%), 6 women (60%)] with widespread parasitic lesions of the liver, who underwent 26 surgical interventions for liver echinococcosis in the surgical department No. 2 on the basis of the M.A. Podgorbunsky” in the period from 2017 to 2022. The difference in the number of operations performed and actual patients is explained by the use of a staged method of surgical treatment. Criteria for inclusion in the study group: the absence of an initiaL sufficient safe LeveL of Liver functionaL reserves to perform a one-stage extensive Liver resection based on the results of a comprehensive assessment of clinical, laboratory and instrumental tests in conjunction with the use of a statistical prognostic model. Results. All patients (10/100%) from the study group underwent laparoscopic vascular isolation of the portal blood flow of the right Lobe of the Liver in order to create vicarious hypertrophy of the contralateral Lobe and increase the reserve capacity of the Liver. After objective confirmation of the effectiveness of the above surgical stage of treatment, assessment of the perioperative risk using a statistical model, aLL underwent extensive Liver resections as the next stage. In the postoperative period, 8/80% of patients had post-resection hepatic insufficiency of class A (n = 4) and B (n = 4) according to the ISGLS classification. In two patients, the clinical picture and the absence of Liver dysfunctions (synthetic, secretory, detoxification) made it possible to judge the absence of Liver failure in the postoperative period. Against the background of conservative therapy, the phenomena of Liver failure regressed. ALL patients were discharged in a satisfactory condition. Findings. Staged Laparoscopic vascular isolation of portal bLood flow is effective and safe. The use of a modern diagnostic algorithm for perioperative examination in combination with staged surgical techniques makes it possible to achieve good treatment results in a specialized surgical center.
    Type of Medium: Online Resource
    ISSN: 1994-9499 , 1994-9480
    URL: Article
    DOI: 10.19163/1994-9480-2022-19-2-85-91
    Language: Unknown
    Publisher: Volgograd State Medical University
    Publication Date: 2022
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  • 10
    Online Resource
    Online Resource
    The question of the influence of the dosed tissue stretching on the concentration of the hypoxia-inducible factor (HIF-1α) in the stretched flap
    VSMU N.N. Burdenko ; 2017
    In:  Vestnik of Experimental and Clinical Surgery Vol. 10, No. 4 ( 2017-12-31), p. 283-287
    Details
    In: Vestnik of Experimental and Clinical Surgery, VSMU N.N. Burdenko, Vol. 10, No. 4 ( 2017-12-31), p. 283-287
    Abstract: Relevance: the method of dosed dermotension as one of the options for plastic reconstruction of the foot with the soft tissue defects of various etiologies (including diabetes mellitus) are widely used in surgery. Local circulatory compensated hypoxia, occurs when dosed dermotension, stimulates proliferation of blood vessels, but to date no proven link between measured growth and the concentration of cytokine HIF-1α. Aim: the aim was to identify patterns between local circulatory compensated hypoxia created by carrying out the dosed dermotension and cytokine concentration of HIF-1α in stretched the flap when closing the wound of the soft tissues. Materials and methods: the experiment was carried out on 18 experimental animals, which was simulated wound scapular area and conducted a hardware apparatus dermotension under the control of laser Doppler flowmetry, formed the skin samples and performed enzyme-linked immunosorbent assay to determine the concentration of cytokine HIF-1α after 30 minutes, 24 hours from the beginning of tissue stretching. Results: the concentration of HIF-1α in the skin before the start of the dermotension was (Me [Q1; Q3]) 110 [98,1; 114,8] ng/ml. A statistically significant increase in the concentration of HIF-1α to 148 [122,2; 221,7] ng/ml (p=0.008) recorded in the group of animals who underwent tissue stretching within 30 minutes, research also showed that the concentration of HIF-1α increased to 330 [246,4; 463,3] ng/ml (p=0.007) after 24 hours from the start of the dosed strains. Conclusion: the concentration of cytokine HIF-1α in stretched the flap increases with dosed dermotension. Thus, the regulation of adaptation of the skin to stretching is performed by increasing the concentration of the cytokine HIF-1α.
    Type of Medium: Online Resource
    ISSN: 2409-143X , 2070-478X
    URL: Article
    DOI: 10.18499/2070-478X-2017-10-4-283-287
    Language: Unknown
    Publisher: VSMU N.N. Burdenko
    Publication Date: 2017
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