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  • 1
    Online Resource
    Online Resource
    The effect of race/ethnicity on cancer-specific mortality after salvage radical prostatectomy
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-8-19)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-8-19)
    Abstract: To test the effect of race/ethnicity on cancer-specific mortality (CSM) after salvage radical prostatectomy (SRP). Material and methods We relied on the Surveillance, Epidemiology and End Results database (SEER, 2004–2016) to identify SRP patients of all race/ethnicity background. Univariate and multivariate Cox regression models addressed CSM according to race/ethnicity. Results Of 426 assessable SRP patients, Caucasians accounted for 299 (69.9%) vs. 68 (15.9%) African-Americans vs. 39 (9.1%) Hispanics vs. 20 (4.7%) Asians. At diagnosis, African-Americans (64 years) were younger than Caucasians (66 years), but not younger than Hispanics (66 years) and Asians (67 years). PSA at diagnosis was significantly higher in African-Americans (13.2 ng/ml), Hispanics (13.0 ng/ml), and Asians (12.2 ng/ml) than in Caucasians (7.8 ng/ml, p = 0.01). Moreover, the distribution of African-Americans (10.3%–36.6%) and Hispanics (0%–15.8%) varied according to SEER region. The 10-year CSM was 46.5% in African-Americans vs. 22.4% in Caucasians vs. 15.4% in Hispanics vs. 15.0% in Asians. After multivariate adjustment (for age, clinical T stage, lymph node dissection status), African-American race/ethnicity was an independent predictor of higher CSM (HR: 2.2, p & lt; 0.01), but not Hispanic or Asian race/ethnicity. The independent effect of African-American race/ethnicity did not persist after further adjustment for PSA. Conclusion African-Americans treated with SRP are at higher risk of CSM than other racial/ethnic groups and also exhibited the highest baseline PSA. The independent effect of African-American race/ethnicity on higher CSM no longer applies after PSA adjustment since higher PSA represents a distinguishing feature in African-American patients.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2022.874945
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 2
    Online Resource
    Online Resource
    Hygrothermal Analysis of CLT-Based Retrofit Strategy of Existing Wall Assemblies According to EN 13788 Standard
    International Information and Engineering Technology Association ; 2021
    In:  TECNICA ITALIANA-Italian Journal of Engineering Science Vol. 65, No. 2-4 ( 2021-07-30), p. 324-329
    Details
    In: TECNICA ITALIANA-Italian Journal of Engineering Science, International Information and Engineering Technology Association, Vol. 65, No. 2-4 ( 2021-07-30), p. 324-329
    Abstract: In the framework of the ongoing EU-funded innovation project called e-SAFE (energy and Seismic Affordable rEnovation solutions), several solutions for the energy and seismic deep renovation of reinforced-concrete (RC) framed buildings in the EU countries are going to be developed and demonstrated. One of these solutions makes use of cross laminated timber (CLT) panels connected to the existing RC frame through specifically designed dampers to increase the seismic and energy performances of the existing envelope. This paper aims to preliminary assess the hygrothermal performance of such CLT panels when applied to various typical wall structures under different climate conditions in Italy through numerical simulations carried out according to the EN 13788 Standard and considering various indoor vapor production classes. Results show that the most problematic existing wall structures are uninsulated concrete walls, for which a risk of surface condensation and mold growth is predicted in all climate zones because of their low thermal resistance (U-value of 3.55 W·m-2·K-1), followed by uninsulated solid brick walls (U-value of 1.81 W·m-2·K-1). The application of CLT panels is found to not only significantly improve the thermal behaviour of the walls, but also to eliminate any surface and interstitial condensation issues in all climate zones.
    Type of Medium: Online Resource
    ISSN: 0040-1846
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.18280/ti-ijes.652-4
    DOI: 10.18280/ti-ijes
    DOI: 10.18280/ti-ijes.652-428
    Language: Unknown
    Publisher: International Information and Engineering Technology Association
    Publication Date: 2021
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  • 3
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    Online Resource
    The Kyoto Rotation Fund as a policy tool for climate change mitigation: The case study of an Italian school
    International Information and Engineering Technology Association ; 2017
    In:  International Journal of Heat and Technology Vol. 35, No. Special Issue1 ( 2017-9-20), p. S159-S165
    Details
    In: International Journal of Heat and Technology, International Information and Engineering Technology Association, Vol. 35, No. Special Issue1 ( 2017-9-20), p. S159-S165
    Type of Medium: Online Resource
    ISSN: 0392-8764 , 0392-8764
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.18280/ijht.35Sp01
    DOI: 10.18280/ijht
    DOI: 10.18280/ijht.35Sp0122
    Language: Unknown
    Publisher: International Information and Engineering Technology Association
    Publication Date: 2017
    detail.hit.zdb_id: 2874927-3
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  • 4
    Online Resource
    Online Resource
    A novel expressed prostatic secretion (EPS)-urine metabolomic signature for the diagnosis of clinically significant prostate cancer
    China Anti-cancer Association ; 2021
    In:  Cancer Biology & Medicine Vol. 18, No. 2 ( 2021-05-15), p. 604-615
    Details
    In: Cancer Biology & Medicine, China Anti-cancer Association, Vol. 18, No. 2 ( 2021-05-15), p. 604-615
    Abstract: Objective: Significant efforts are currently being made to identify novel biomarkers for the diagnosis and risk stratification of prostate cancer (PCa). Metabolomics can be a very useful approach in biomarker discovery because metabolites are an important read-out of the disease when characterized in biological samples. We aimed to determine a metabolomic signature which can accurately distinguish men with clinically significant PCa from those affected by benign prostatic hyperplasia (BPH). Methods: We first performed untargeted metabolomics using ultrahigh-performance liquid chromatography tandem mass spectrometry on expressed prostatic secretion urine (EPS-urine) from 25 patients affected by BPH and 25 men with clinically significant PCa (defined as Gleason score ≥ 3 + 4). Diagnosis was histologically confirmed after surgical treatment. The EPS-urine metabolomic approach was then applied to a larger, prospective cohort of 92 consecutive patients undergoing multiparametric magnetic resonance imaging for clinical suspicion of PCa prior to biopsy. Results: We established a novel metabolomic signature capable of accurately distinguishing PCa from benign tissue. A metabolomic signature was associated with clinically significant PCa in all subgroups of the Prostate Imaging Reporting and Data System (PI-RADS) classification (100% and 89.13% of accuracy when the PI-RADS was in range of 1–2 and 4–5, respectively, and 87.50% in the more critical cases when the PI-RADS was 3). Conclusions: A combination of metabolites and clinical variables can effectively help in identifying PCa patients that might be overlooked by current imaging technologies. Metabolites from EPS-urine should help in defining the diagnostic pathway of PCa, thus improving PCa detection and decreasing the number of unnecessary prostate biopsies.
    Type of Medium: Online Resource
    ISSN: 2095-3941
    URL: Article
    DOI: 10.20892/j.issn.2095-3941.2020.0617
    Language: Unknown
    Publisher: China Anti-cancer Association
    Publication Date: 2021
    detail.hit.zdb_id: 2676322-9
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  • 5
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    Online Resource
    Phase space holes in non-periodic plasmas
    Cambridge University Press (CUP) ; 2003
    In:  Journal of Plasma Physics Vol. 69, No. 2 ( 2003-2), p. 93-108
    Details
    In: Journal of Plasma Physics, Cambridge University Press (CUP), Vol. 69, No. 2 ( 2003-2), p. 93-108
    Type of Medium: Online Resource
    ISSN: 0022-3778 , 1469-7807
    URL: Article
    DOI: 10.1017/S0022377803002101
    Language: Unknown
    Publisher: Cambridge University Press (CUP)
    Publication Date: 2003
    detail.hit.zdb_id: 2004297-8
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  • 6
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    The conservative and pharmacological management of chronic subdural haematoma: a systematic review
    SMW Supporting Association ; 2017
    In:  Swiss Medical Weekly Vol. 147, No. 0304 ( 2017-01-17), p. w14398-
    Details
    In: Swiss Medical Weekly, SMW Supporting Association, Vol. 147, No. 0304 ( 2017-01-17), p. w14398-
    Abstract: Chronic subdural haematoma (cSDH), one of the most common neurosurgical entities, occurs typically in elderly patients. The incidence is expected to double by the year 2030, owing to the continuous aging of the population. Surgery is usually the treatment of choice, but conservative treatment may be a good alternative in some situations. We provide a systematic review of studies analysing the conservative treatment options and the natural history of cSDH. Of 231 articles screened, 35 were included in this systematic review. Studies evaluating the natural history and conservative treatment modalities of cSDH remain sparse and are predominantly of low level of evidence. The natural history of cSDH remains unclear and is analysed only in case reports or very small case series. “Wait and watch” or “wait and scan” management is indicated in patients with no or minor symptoms (Markwalder score 0–1). However, it seems that there are no clear clinical or radiological signs indicating whether the cSDH will resolve spontaneously or not (type C recommendation). In symptomatic patients who are not worsening or in a comatose state, oral steroid treatment might be an alternative to surgery (type C recommendation). Tranexamic acid proved effective in a small patient series (type C recommendation), but its risk of increasing thromboembolic events in patients treated with antithrombotic or anticoagulant medication is unclear. Angiotensin converting-enzyme inhibitors were evaluated only as adjuvant therapy to surgery, and their effect on the rate of recurrence remains debatable. Mannitol showed promising results in small retrospective series and might be a valid treatment modality (type C recommendation). However, the long treatment duration is a major drawback. Patients presenting without paresis can be treated with a platelet activating factor receptor antagonist (type C recommendation), since they seem to promote resolution of the haematoma, especially in patients with hygromas or low-density haematomas on computed tomography. Lastly, atorvastatin seems to be a safe option for the conservative treatment of asymptomatic or mildly symptomatic cSDH patients (type C recommendation). In conclusion, our knowledge of the conservative treatment modalities for cSDH is sparse and based on small case series and low grade evidence. However, some treatment modalities seem promising even in symptomatic patients with large haematomas. Randomised controlled trials are currently underway, and will hopefully provide us with good evidence for or against the conservative treatment of cSDH.
    Type of Medium: Online Resource
    ISSN: 1424-3997
    URL: Article
    DOI: 10.57187/smw.2017.14398
    Language: Unknown
    Publisher: SMW Supporting Association
    Publication Date: 2017
    detail.hit.zdb_id: 2031164-3
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  • 7
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    Online Resource
    Predicting the probability of pT3 or higher pathological stage at radical prostatectomy: COVID19-specific considerations
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-12-6)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-12-6)
    Abstract: We tested whether a model identifying prostate cancer (PCa) patients at risk of pT3-4/pN1 can be developed for use during COVID19 pandemic, in order to guarantee appropriate treatment to patients harboring advanced disease patients without compromising sustainability of care delivery. Methods Within the Surveillance, Epidemiology and End Results database 2010-2016, we identified 27,529 patients with localized PCa and treated with radical prostatectomy. A multivariable logistic regression model predicting presence of pT3-4/pN1 disease was fitted within a development cohort (n=13,977, 50.8%). Subsequently, external validation (n=13,552, 49.2%) and head-to-head comparison with NCCN risk group stratification was performed. Results In model development, age, PSA, biopsy Gleason Grade Group (GGG) and percentage of positive biopsy cores were independent predictors of pT3-4/pN1 stage. In external validation, prediction of pT3-4/pN1 with novel nomogram was 74% accurate versus 68% for NCCN risk group stratification. Nomogram achieved better calibration and showed net-benefit over NCCN risk group stratification in decision curve analyses. The use of nomogram cut-off of 49% resulted in pT3-4/pN1 rate of 65%, instead of the average 35%. Conclusion The newly developed, externally validated nomogram predicts presence of pT3-4/pN1 better than NCCN risk group stratification and allows to focus radical prostatectomy treatment on individuals at highest risk of pT3-4/pN1.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2022.990851
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 8
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    Online Resource
    DataSheet_1.pdf
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-9-5)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-9-5)
    Abstract: With the advent of immuno-oncology compounds in randomized trials, we observe more and more survival curves crossing. From a statistical standpoint this corresponds to violation of the proportional hazard assumption. When this occurs, the hazard ratio from the Cox regression is not reliable as an estimate. Herein, we aimed to identify the most appropriate IO-based therapy for metastatic renal cell carcinoma applying an alternative method to overcome the issue of hazard assumption violation for meta-analyses. Methods Pubmed, EMBASE, Web of Science and Scopus databases were searched. Only phase III randomized clinical trials on IO-IO (nivo-ipi) or IO-TKI combinations were included. An algorithm to obtain survival data from published Kaplan-Meier curves was used to reconstruct data on overall survival (OS), progression-free survival (PFS) and duration of response (DoR). Differences in restricted mean survival time (RMST) were used for comparisons. Results individual survival data from 4,206 patients from five trials were reconciled. Patients who received nivo-ipi or IO-TKI had better OS, PFS and DoR relative to sunitinib (all p & lt;0.001). Patients who received IO-TKI had similar OS and PFS relative to nivo-ipi, with a 36-month ΔRMST of -0.55 (95% CI: -1.71-0.60; p=0.3) and -1.5 (95% CI: -2.9-0.0; p=0.051) months, respectively. Regarding DoR, patients who received nivo-ipi had longer duration of response relative to IO-TKI, with a 24-month ΔRMST of 1.5 (95% CI: 0.2-2.8; p=0.02) months. Conclusion Despite overall similar OS and PFS for patients receiving nivo-ipi and IO-TKI combinations, DoR was more favorable in patients who received nivo-ipi compared to IO-TKI. A meta-analysis based on differences in RMST is a useful alternative whenever the proportional hazard assumption is violated. Systematic Review Registration: https://www.crd.york.ac.uk/prospero/ , identifier CRD42021241421.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2022.955894
    DOI: 10.3389/fonc.2022.955894.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 9
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    Online Resource
    An external validation of the nocera nomogram: Predicting non-organ confined stage of ≥pT3 in cT1 clear cell renal cell carcinoma
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-10-10)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-10-10)
    Abstract: Only one previously published study by Nocera et al. addressed the risk of upstaging to ≥pT3 in cT1 clear cell renal cell carcinoma (ccRCC) by using characteristics of the R.E.N.A.L and PADUA score (age, tumor size, rim location, exophytic rate, polar involvement) developing an accurate nomogram. However, this nomogram has never been externally validated yet. Material and methods The study cohort consisted of 288 patients with cT1a-b ccRCC, diagnosed between 2008-2021 at the University Hospital Frankfurt, Germany. Analyses addressed clinical, tumor and radiographic characteristics. The external validation of the nomogram relied on accuracy calculations derived from the area under the curve of the receiver operator characteristic analysis. Results Overall, 11.8% (n=34) patients harbored ≥pT3 ccRCC. Median radiographic tumor size (3.6 vs . 5.3cm), R.E.N.A.L. (8 vs . 9 points) and PADUA score (9 vs . 11 points), as well as proportions of renal sinus involvement (82.4% vs . 51.6%), renal hilus involvement (44.1 vs . 13.0%), and medial rim location significantly differed between the pT1-2 and ≥pT3 group (all p ≤ 0.01). In subgroup analyses of small renal mass ccRCC patients ( & lt;4cm, cT1a), only 3.8% (n=6) patients had ≥pT3 pathology. Upstaged patients were significantly older and more frequently had endophytic tumor than pT1-2 counterparts (p & lt;0.05). The external validation of the Nocera nomogram showed a good accuracy of 76.6%. Using the suggested cut-off of 21%, 26.5% of patients exhibited ≥pT3 ccRCC. Conversely, within patients below cut-off, 5.9% patients exhibited ≥pT3 ccRCC. Conclusion We reported the first external validation of the nomogram addressing the risk of ≥pT3 in cT1 ccRCC patients, demonstrating a good accuracy, with a low false-negative rate. Therefore, the nomogram can accurately be used for patients’ counselling and treatment decision making.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2022.1019057
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 10
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    Energy balances and payback time for controlled mechanical ventilation in residential buildings
    International Information and Engineering Technology Association ; 2016
    In:  International Journal of Heat and Technology Vol. 34, No. Special Issue 2 ( 2016-10-30), p. S315-S322
    Details
    In: International Journal of Heat and Technology, International Information and Engineering Technology Association, Vol. 34, No. Special Issue 2 ( 2016-10-30), p. S315-S322
    Type of Medium: Online Resource
    ISSN: 0392-8764
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.18280/ijht.34Sp02
    DOI: 10.18280/ijht
    DOI: 10.18280/ijht.34Sp0218
    Language: Unknown
    Publisher: International Information and Engineering Technology Association
    Publication Date: 2016
    detail.hit.zdb_id: 2874927-3
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