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  • 1
    In: Research Ideas and Outcomes, Pensoft Publishers, Vol. 9 ( 2023-08-09)
    Abstract: Adequate adaptions and actions to combat anthropogenic climate change (CC) are significant challenges of the 21 st century. In Europe, according to the European Environmental Agency, warming of around 2°C is expected under the moderate climate scenario (RCP 4.5) by the end of the century, but the pessimistic RCP 8.5 scenario project an increase of up to 6°C. In addition to the rise in temperature, changes in precipitation and increased frequency of extreme weather events are predicted. New environmental conditions affect tree species and habitats differently; thus, forest biodiversity and local tree species compositions probably will be altered in many regions in the future. The effects may be manifold: some tree species may persist, locally adapt and migrate, while others may disappear from given regions and be replaced by native or non-native species. The native forests of the Austrian-Hungarian border region are particularly affected by the climate change. To mitigate the consequences of anthropogenic climate change to preserve forest biodiversity for future generations and to enable their use, deliberate and planned human interventions and actions are essential. These require transnational or even global efforts since nature and climate do not recognise man-made borders. The REIN-Forest project (Interreg V-A Austria-Hungary Programme - ATHU150), a bilateral project between Austria and Hungary, aimed to establish harmonised protection measures for the conservation of native forests in Northern, Central and Southern Burgenland, Vienna, Vienna Umland-South, Lower Austria South, Graz and Eastern Styria, Győr-Moson-Sopron, Vas and Zala counties (the so-called programme area). In the scope of this project, international cooperation between three project partners: the Austrian Research Centre for Forests (BFW, Austria), the Forest Research Institute – University of Sopron (SOE ERTI, Hungary) and the Vas County Government Office (VVÖH, Hungary) was established. Previous results and outputs of the SUSTREE project (Interreg Central Europe CE614), such as: a) Transnational delineation model of conservation and forest seed transfer zones in climate change, b) Report of intraspecific response function and derivation of climate transfer limits, SusSelect data, recommendations and c) Application of the species distribution models for the delineation of seed transfer zones/models in Central Europe, were put into practice during the project, focusing on two native deciduous forest tree species of the Austrian-Hungarian border region: European beech ( Fagus sylvatica L.) and sessile oak ( Quercus petraea (Matt.) Liebl.). During the REIN-Forest project, the following joint documents were prepared and several activities were implemented: 1. Model-based document on the current state and future perspectives of European beech and sessile oak forests; 2. Bilateral strategy for the transfer of forest reproductive material (FRM) and its use in the Austrian-Hungarian border region; 3. Establishment of altogether six demonstration sites (three in each country) with local and climate-adapted FRM of European beech and sessile oak for long-term monitoring; 4. Management and monitoring plan of the demonstration sites; 5. Joint bilingual communication strategy, which included informative programmes and meetings with professionals, locals and schools and also education material for further use. REIN-Forest focused on using scientific results and outputs in the field of applied forestry and awareness-raising. Besides strategies, recommendations and reports that would facilitate forest managers' decisions for the future in the border region, events and workshops were offered for forestry practitioners, school pupils and the public and a short film and educational materials were published.
    Type of Medium: Online Resource
    ISSN: 2367-7163
    Language: Unknown
    Publisher: Pensoft Publishers
    Publication Date: 2023
    detail.hit.zdb_id: 2833254-4
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  • 2
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 12 ( 2021-12-22)
    Abstract: A subset of interstitial lung diseases (ILDs) with autoimmune traits—including connective tissue disease-associated ILD (CTD-ILD) and interstitial pneumonia with autoimmune features (IPAF)—develops progressive fibrosing (PF)-ILD. The aim of our study was to evaluate the clinical characteristics and predictors of longitudinal lung function (LF) changes in autoimmune PF-ILD patients in a real-world setting. All ILD cases with confirmed or suspected autoimmunity discussed by a multidisciplinary team (MDT) between January 2017 and June 2019 ( n = 511) were reviewed, including 63 CTD-ILD and 44 IPAF patients. Detailed medical history, LF test, diffusing capacity of the lung for carbon monoxide (DLCO), 6-min walk test (6MWT), blood gas analysis (BGA), and high-resolution computer tomography (HRCT) were performed. Longitudinal follow-up for functional parameters was at least 2 years. Women were overrepresented (70.1%), and the age of the IPAF group was significantly higher as compared to the CTD-ILD group ( p & lt; 0.001). Dyspnea, crackles, and weight loss were significantly more common in the IPAF group as compared to the CTD-ILD group (84.1% vs. 58.7%, p = 0.006; 72.7% vs. 49.2%, p = 0.017; 29.6% vs. 4.8%, p = 0.001). Forced vital capacity (FVC) yearly decline was more pronounced in IPAF (53.1 ± 0.3 vs. 16.7 ± 0.2 ml; p = 0.294), while the majority of patients (IPAF: 68% and CTD-ILD 82%) did not deteriorate. Factors influencing progression included malignancy as a comorbidity, anti-SS-A antibodies, and post-exercise pulse increase at 6MWT. Antifibrotic therapy was administered significantly more often in IPAF as compared to CTD-ILD patients ( n = 13, 29.5% vs. n = 5, 7.9%; p = 0.007), and importantly, this treatment reduced lung function decline when compared to non-treated patients. Majority of patients improved or were stable regarding lung function, and autoimmune-associated PF-ILD was more common in patients having IPAF. Functional decline predictors were anti-SS-A antibodies and marked post-exercise pulse increase at 6MWT. Antifibrotic treatments reduced progression in progressive fibrosing CTD-ILD and IPAF, emphasizing the need for guidelines including optimal treatment start and combination therapies in this special patient group.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2587355-6
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  • 3
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 148, No. 31 ( 2007-08-1), p. 1469-1473
    Abstract: Irodalmi adatok szerint az intenzív osztályokon a nosocomialis fertőzések száma többszöröse a nem intenzív osztályos betegekének. Az életmentő technológia fejlődése növelte a kórházi fertőzések kialakulásának veszélyét az elmúlt évtizedekben. Széles körben elfogadott, hogy epidemiológiai módszert szükséges alkalmazni a kórházi fertőzések felderítésére, az előfordulási arány megállapítására, a járvány korai felismerésére és az infekciókontroll-intézkedések hatékonyságának lemérésére. Cél: Nosocomialis surveillance alkalmazása a nosocomialis fertőzések epidemiológiájának megismerése a Kenézy Gyula Kórház Intenzív Osztályán. Módszerek: A Kenézy Gyula Kórház 1637 ágyas megyei kórház, 16 ágyas Központi Intenzív osztállyal. A vizsgált időszak alatt (2004. április 1.–2006. március 31.) az interdiszciplináris intenzív osztályon 1490 beteget ápoltak, az összes ápolási nap száma 8058 volt. Az ápoltak leggyakrabban légzési elégtelenség, politraumatizáció vagy fejsérülés diagnózisokkal kerültek felvételre. A klinikai adatokat epidemiológus szakápoló gyűjtötte, előzetesen összeállított infekciókontroll-adatlap alapján. A kórházi fertőzések azonosítására CDC-definíciókat alkalmaztak. Eredmények: A vizsgált időszakban 194 nosocomialis infekciót detektáltak 134 betegnél. Az incidencia 13,0 száz betegre vonatkoztatva, az incidenciasűrűség pedig 24,0 ezer ápolási napra vonatkoztatva. A leggyakoribb kórházi fertőzés a légúti infekció volt (44,3%) majd azt követték a húgyúti (21,1%) és a véráramfertőzések (20,1%). Következtetések: A nosocomialis fertőzések felkutatására nosocomialis surveillance-t kell folytatni az intenzív osztályokon. A nosocomialis surveillance interdiszciplináris megközelítést és orvos-nővér szakmai együttműködést kíván. A beteg-nővér arány független rizikófaktor. Az egészségügyi intézmények létszám-racionalizálásánál figyelembe kell venni, hogy az intenzív osztályokon a beteg-nővér arány csökkentése a kórházi fertőzések számának növekedéséhez vezet.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    Language: Unknown
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2007
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  • 4
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 12 ( 2021-4-29)
    Abstract: Congenital heart defects (CHD) are the most common developmental abnormalities, affecting approximately 0.9% of livebirths. Genetic factors, including copy number variations (CNVs), play an important role in their development. The most common CNVs are found on chromosome 22q11.2. The genomic instability of this region, caused by the eight low copy repeats (LCR A-H), may result in several recurrent and/or rare microdeletions and duplications, including the most common, ∼3 Mb large LCR A-D deletion (classical 22q.11.2 deletion syndrome). We aimed to screen 22q11.2 CNVs in a large Hungarian pediatric and adult CHD cohort, regardless of the type of their CHDs. All the enrolled participants were cardiologically diagnosed with non-syndromic CHDs. A combination of multiplex ligation-dependent probe amplification (MLPA), chromosomal microarray analysis and droplet digital PCR methods were used to comprehensively assess the detected 22q11.2 CNVs in 212 CHD-patients. Additionally, capillary sequencing was performed to detect variants in the TBX1 gene, a cardinal gene located in 22q11.2. Pathogenic CNVs were detected in 5.2% (11/212), VUS in 0.9% and benign CNVs in 1.8% of the overall CHD cohort. In patients with tetralogy of Fallot the rate of pathogenic CNVs was 17% (5/30). Fifty-four percent of all CNVs were typical proximal deletions (LCR A-D). However, nested (LCR A-B) and central deletions (LCR C-D), proximal (LCR A-D) and distal duplications (LCR D-E, LCR D-H, LCR E-H, LCR F-H) and rare combinations of deletions and duplications were also identified. Segregation analysis detected familial occurrence in 18% (2/11) of the pathogenic variants. Based on in-depth clinical information, a detailed phenotype–genotype comparison was performed. No pathogenic variant was identified in the TBX1 gene. Our findings confirmed the previously described large phenotypic diversity in the 22q11.2 CNVs. MLPA proved to be a highly efficient genetic screening method for our CHD-cohort. Our results highlight the necessity for large-scale genetic screening of CHD-patients and the importance of early genetic diagnosis in their clinical management.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606823-0
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  • 5
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 163, No. 18 ( 2022-05-01), p. 702-711
    Abstract: Összefoglaló. A pseudoxanthoma elasticum (PXE, OMIM # 264800) egy autoszomális recesszív módon öröklődő multiszisztémás érintettséggel járó kórkép, melynek háttérében az ABCC6 gén mutációi állnak. A tünetek kialakulásának oka az ektópiás mineralizáció. Kalcium-só kristályok rakódnak le elsősorban a bőrben, a szem Bruch-membránjában és az erek endotheliumában, így a bőrelváltozások mellett a látás csökkenése és cardiovascularis eltérések is jelentkezhetnek. A klinikai tünetek változó súlyosságúak lehetnek, heterogén megjelenésűek. A betegek fenotípusának azonosítása, valamint gondozása multidiszciplináris feladat, bőrgyógyász, szemész, kardiológus és klinikai genetikus együttműködésén alapul. Célunk, hogy bemutassuk a betegségben előforduló tüneteket, melyek ismerete megkönnyíti a kórkép felismerését, illetve hogy felhívjuk a figyelmet a korai diagnózis fontosságára és ismertessük a korszerű diagnosztikai módszereket. A súlyos szisztémás tünetek kialakulása miatt rendkívüli jelentőséggel bír a társszakmák együttműködése, hogy a korai diagnózis által időben megfelelő gondozásban és terápiában részesülhessenek a betegek. Orv Hetil. 2022; 163(18): 702–711. Summary. Pseudoxanthoma elasticum (PXE, OMIM # 264800) is an autosomal recessive, multisystemic disorder, associated with mutations of the ABCC6 gene. Ectopic mineralization is in the background of the clinical manifestations of the disease. Calcium-salt crystals are deposited primarily in the skin, in the Bruch membrane of the eyes, and in the vascular endothelium. Thus, in addition to the skin lesions, visual impairment and cardiovascular involvement also occur. Clinical symptoms show varying severity and display heterogeneous appearance. The identification of the phenotype and care of the patients require a multidisciplinary perspective based on the collaboration of a dermatologist, ophthalmologist, cardiologist, and clinical geneticist. The aim of our work is to describe the development of symptoms of the disease, in order to facilitate the diagnosis. In addition, we aim to draw attention to the importance of early diagnosis of pseudoxanthoma elasticum, and to present modern diagnostic methods. Considering the development of severe systemic complications, the early diagnosis with the collaboration between related specialists is crucial to provide optimal clinical care and management of the patients. Orv Hetil. 2022; 163(18): 702–711.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    Language: Unknown
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2022
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  • 6
    In: Orvosi Hetilap, Akademiai Kiado Zrt., Vol. 151, No. 35 ( 2010-08-1), p. 1403-1408
    Abstract: A multifaktoriális betegségek patogenezisének vizsgálata a posztgenomiális éra nagy kihívása. Egyes pszichiátriai kórképek – mint például a szkizofrénia – hátterében erős genetikai determináció figyelhető meg. A pszichiátriai betegségek kezelésére használatos antipszichotikumok és antidepresszánsok gyakran nem kívánt mellékhatásokat eredményeznek, amelyek alapjai szintén genetikailag kódoltak. A krónikus multifaktoriális betegségek vizsgálatában fontos szerep jut a nagyszámú minta tárolására és azok klinikai adatokkal való összekötésére lehetőséget adó biobankoknak, amelyek építése világszerte folyik. Hazánkban is számos ilyen gyűjtemény kialakítása van folyamatban. Az első hazai neurológiai és pszichiátriai biobankhálózat a Magyar Klinikai Neurogenetikai Társaság által működtetett NEPSYBANK volt. A hazai biobankok hálózattá formálása a Nemzeti Kutatási és Technológiai Hivatal NEKIFUT programjának szervezésében jelenleg zajlik. Közleményünkben egy olyan konzorciális biobankról (SCHIZOBANK) számolunk be, amelynek építését a hazai akadémiai szféra és gyógyszeripar kezdeményezésére a Schizo-08 Konzorcium vezetése mellett öt nagy hazai pszichiátria centrum klinikusai végzik. A SCHIZOBANK felépítése, logisztikája, informatikai háttere ismertetése mellett áttekintjük a biobankok jelentőségét, és számba vesszük a nemzetközi szkizofréniabiobank-kezdeményezéseket. A SCHIZOBANK erőssége a betegek rendkívül részletes fenotipizálása mellett, hogy egyes biológiai minták (RNS és plazma) levétele az akut pszichózis és a remisszió állapotában is megtörténik. Így nemcsak statikus genomikai jellegzetességek, hanem a betegség kórlefolyása során dinamikusan változó génexpressziós, proteomikai és metabolomikai markerek vizsgálatára is lehetőség nyílik. A SCHIZOBANK nemcsak a konzorcium tagjai, hanem külső kutatók számára is elérhető. Célunk a más országok biobankjaival való harmonizálás is.
    Type of Medium: Online Resource
    ISSN: 0030-6002 , 1788-6120
    Language: Unknown
    Publisher: Akademiai Kiado Zrt.
    Publication Date: 2010
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  • 7
    Online Resource
    Online Resource
    Ideggyogyaszati Szemle Journal ; 2017
    In:  Ideggyógyászati szemle Vol. 70, No. 9-10 ( 2017), p. 343-348
    In: Ideggyógyászati szemle, Ideggyogyaszati Szemle Journal, Vol. 70, No. 9-10 ( 2017), p. 343-348
    Type of Medium: Online Resource
    ISSN: 0019-1442
    Language: Unknown
    Publisher: Ideggyogyaszati Szemle Journal
    Publication Date: 2017
    detail.hit.zdb_id: 2973368-6
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  • 8
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-10-5)
    Abstract: To evaluate the patient- and procedure-related predictors of transcatheter aortic-valve implantation (TAVI)-associated ischemic brain lesions and to assess the effect of silent cerebral ischemic lesions (SCIL) on neurocognitive function. Methods and results We investigated 113 consecutive patients with severe aortic stenosis who underwent brain magnetic resonance imaging (MRI) within a week following TAVI. To assess periprocedural cerebral ischemic lesions, diffusion-weighted MRI was utilized. We used multivariate linear regression to identify the independent predictors of TAVI-related ischemic lesion volume (ILV) and periprocedural stroke. Neurocognitive evaluation was performed before and following TAVI at 6-month and one-year follow-up. Following TAVI, a total of 944 new cerebral ischemic lesions were detected in 104 patients (92%). The median ILV was 257 μl (interquartile range [IQR]:97.1–718.8μl) with a median lesion number of 6/patient [IQR:2–10] . The majority of ischemic lesions were clinically silent (95%), while 5% of the lesions induced a stroke, which was confirmed by MRI. Predilatation (β = 1.13[95%CI:0.32–1.93], p = 0.01) and the number of valve positioning attempts during implantation (β = 0.28[95%CI:0.06–0.50], p = 0.02) increased the log-transformed total ILV. Predilatation (OR = 12.04[95%CI:1.46–99.07], p = 0.02) and alternative access routes (OR = 7.84[95%CI:1.01–61.07], p = 0.02) were associated with stroke after adjustments for comorbidities and periprocedural factors. The presence of SCILs were not associated with a change in neurocognitive function that remained stable during the one-year follow-up. Conclusion While periprocedural ischemic lesions are frequent, most of them are clinically silent and might not impact the patients' neurocognitive function. The number of valve positioning attempts, predilatation, and alternative access routes should be taken into consideration during TAVI to reduce the ILV and risk for stroke.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2781496-8
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  • 9
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-4-25)
    Abstract: Transcatheter aortic valve implantation (TAVI) can improve left ventricular (LV) mechanics and survival. Data on the predictive value of left atrial (LA) strain following TAVI are scarce. We aimed to evaluate the association of LA strain measured shortly post-TAVI with functional and anatomical reverse remodeling of the LA and LV, and its association with mortality. Methods We prospectively investigated 90 patients who underwent TAVI. Transthoracic echocardiography including strain analysis was performed shortly after TAVI and repeated 6 months later. CT angiography (CTA) was performed for pre-TAVI planning and 6 months post-TAVI. Speckle tracking echocardiography was used to determine LA peak reservoir strain (LASr) and LV global longitudinal strain (LV-GL), LA volume index (LAVi) was measured by TTE. LV mass index (LVMi) was calculated using CTA images. LA reverse remodeling was based on LASr and LAVi changes, whereas LV reverse remodeling was defined as an improvement in LV-GLS or a reduction of LVMi. The association of severely reduced LASr ( & lt;20%) at baseline with changes (Δ) in LASr, LAVi, LV-GLS and LVMi were analyzed using linear regression, and Cox proportional hazard model for mortality. Results Mean LASr and LV-GLS were 17.7 ± 8.4 and −15.3 ± 3.4% at baseline and 20.2 ± 10.2 and −16.6 ± 4.0% at follow-up ( p = 0.024 and p & lt; 0.001, respectively). Severely reduced LASr at baseline was associated with more pronounced ΔLASr (β = 5.24, p = 0.025) and LVMi reduction on follow-up (β = 5.78, p = 0.036), however, the majority of the patients had & lt;20% LASr on follow-up (44.4%). Also, ΔLASr was associated with ΔLV-GLS (adjusted β = 2.10, p & lt; 0.001). No significant difference in survival was found between patients with baseline severely reduced LASr ( & lt;20%) and higher LASr (≥20%) ( p = 0.054). Conclusion LV reverse remodeling based on LVMi was present even in patients with severely reduced LASr following TAVI, although extensive LA damage based on LA strain was demonstrated by its limited improvement over time. Clinical Trial Registration ( ClinicalTrials.gov number: NCT02826200).
    Type of Medium: Online Resource
    ISSN: 2297-055X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2781496-8
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  • 10
    Online Resource
    Online Resource
    Frontiers Media SA ; 2020
    In:  Frontiers in Pharmacology Vol. 11 ( 2020-11-26)
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 11 ( 2020-11-26)
    Abstract: Background: Rheumatoid arthritis (RA) patients have a shorter life expectancy than the general population primarily due to cardiovascular comorbidities. Objectives: To characterize arterial aging in RA. Patients and Methods: Coronary calcium score (CCS) were available from 112 RA patients; out of these patients, follow-up CCS were measured for 54 randomly selected individuals. Control CCS were obtained from the MESA database (includes 6,000 & lt; participants); arterial age was calculated from CCS. Results: RA patients were significantly older (10.45 ± 18.45 years, p & lt; 0.001) in terms of the arterial age than the age-, gender-, and race-matched controls. The proportion of RA patients who had zero CCS was significantly less ( p & lt; 0.01) than that of those in the MESA reference group. Each disease year contributed an extra 0.395 years ( p & lt; 0.01) on the top of the normal aging process. However, the rate of the accelerated aging is not uniform, in the first years of the disease it is apparently faster. Smoking ( p & lt; 0.05), previous cardiovascular events ( p & lt; 0.05), and high blood pressure ( p & lt; 0.05) had additional significant effect on the aging process. In the follow-up study, inflammatory disease activity (CRP & gt; 5 mg/L, p & lt; 0.05) especially in smokers and shorter than 10 years of disease duration ( p = 0.05) had the largest impact. Conclusion: Arterial aging is faster in RA patients than in control subjects, particularly in the first 10 years of the disease. Inflammation, previous cardiovascular events, and smoking are additional contributing factors to the intensified coronary atherosclerosis progression. These data support that optimal control of inflammation is essential to attenuate the cardiovascular risk in RA.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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