In:
Frontiers in Endocrinology, Frontiers Media SA, Vol. 13 ( 2022-10-10)
Abstract:
Rates of type 2 diabetes (T2D) among adolescents are on the rise. Epigenetic changes could be associated with the metabolic alterations in adolescents with T2D. Methods We performed a cross sectional integrated analysis of DNA methylation data from peripheral blood mononuclear cells with serum metabolomic data from First Nation adolescents with T2D and controls participating in the Improving Renal Complications in Adolescents with type 2 diabetes through Research (iCARE) cohort study, to explore the molecular changes in adolescents with T2D. Results Our analysis showed that 43 serum metabolites and 36 differentially methylated regions (DMR) were associated with T2D. Several DMRs were located near the transcriptional start site of genes with established roles in metabolic disease and associated with altered serum metabolites (e.g. glucose, leucine, and gamma-glutamylisoleucine). These included the free fatty acid receptor-1 (FFAR1 ), upstream transcription factor-2 ( USF2 ), and tumor necrosis factor-related protein-9 ( C1QTNF9 ), among others. Conclusions We identified DMRs and metabolites that merit further investigation to determine their significance in controlling gene expression and metabolism which could define T2D risk in adolescents.
Type of Medium:
Online Resource
ISSN:
1664-2392
DOI:
10.3389/fendo.2022.934706
DOI:
10.3389/fendo.2022.934706.s001
DOI:
10.3389/fendo.2022.934706.s002
DOI:
10.3389/fendo.2022.934706.s003
DOI:
10.3389/fendo.2022.934706.s004
DOI:
10.3389/fendo.2022.934706.s005
DOI:
10.3389/fendo.2022.934706.s006
DOI:
10.3389/fendo.2022.934706.s007
DOI:
10.3389/fendo.2022.934706.s008
DOI:
10.3389/fendo.2022.934706.s009
DOI:
10.3389/fendo.2022.934706.s010
DOI:
10.3389/fendo.2022.934706.s011
DOI:
10.3389/fendo.2022.934706.s012
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2592084-4
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