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  • 1
    Online Resource
    Online Resource
    Gut Microbiotic Features Aiding the Diagnosis of Acute Ischemic Stroke
    Frontiers Media SA ; 2020
    In:  Frontiers in Cellular and Infection Microbiology Vol. 10 ( 2020-12-21)
    Details
    In: Frontiers in Cellular and Infection Microbiology, Frontiers Media SA, Vol. 10 ( 2020-12-21)
    Abstract: Increasing evidence suggests that features of the gut microbiota correlate with ischemic stroke. However, the specific characteristics of the gut microbiota in patients suffering different types of ischemic stroke, or recovering from such strokes, have rarely been studied, and potential microbiotic predictors of different types of stroke have seldom been analyzed. We subjected fecal specimens from patients with lacunar or non-lacunar acute ischemic infarctions, and those recovering from such strokes, to bacterial 16S rRNA sequencing and compared the results to those of healthy volunteers. We identified microbial markers of different types of ischemic stroke and verified that these were of diagnostic utility. Patients with two types of ischemic stroke, and those recovering from ischemic stroke, exhibited significant shifts in microbiotic diversities compared to healthy subjects. Cluster of Orthologous Groups of Proteins (COG) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses revealed reduced metabolic and transport-related pathway activities in ischemic stroke patients. We performed fivefold cross-validation using a Random Forest model to identify two optimal bacterial species (operational taxonomic units; OTUs) serving as markers of lacunar infarction; these were Lachnospiraceae (OTU_45) and Bacteroides (OTU_4), and the areas under the receiver operating characteristic curves (AUCs under the ROCs) were 0.881 and 0.872 respectively. In terms of non-lacunar acute ischemic infarction detection, the two optimal species were Bilophila (OTU_330) and Lachnospiraceae (OTU_338); the AUCs under the ROCs were 0.985 and 0.929 respectively. In post-ischemic stroke patients, the three optimal species were Pseudomonas (OTU_35), Sphingomonadaceae (OTU_303), and Akkermansia (OTU_9); the AUCs under the ROCs were 1, 0.897, and 0.846 respectively. Notably, the gut microbial markers were of considerable value for utility when diagnosing lacunar infarction, non-lacunar acute ischemic infarction, and post-ischemic stroke. This study is the first to characterize the gut microbiotic profiles of patients with lacunar or non-lacunar, acute ischemic strokes, and those recovering from stroke, and to identify microbiotic predictors of such strokes.
    Type of Medium: Online Resource
    ISSN: 2235-2988
    URL: Article
    DOI: 10.3389/fcimb.2020.587284
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2020
    detail.hit.zdb_id: 2619676-1
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  • 2
    Online Resource
    Online Resource
    Mach-Zehnder Interferometer Sensor Curvature Demodulation Method Based on the Orthogonal Decomposition of Spectral Curves
    Institute of Electrical and Electronics Engineers (IEEE) ; 2020
    In:  IEEE Access Vol. 8 ( 2020), p. 32412-32420
    Details
    In: IEEE Access, Institute of Electrical and Electronics Engineers (IEEE), Vol. 8 ( 2020), p. 32412-32420
    Type of Medium: Online Resource
    ISSN: 2169-3536
    URL: Journal
    URL: Article
    DOI: 10.1109/Access.6287639
    DOI: 10.1109/ACCESS.2020.2973405
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2020
    detail.hit.zdb_id: 2687964-5
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  • 3
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    Calcium Dobesilate (CaD) Attenuates High Glucose and High Lipid-Induced Impairment of Sarcoplasmic Reticulum Calcium Handling in Cardiomyocytes
    Frontiers Media SA ; 2021
    In:  Frontiers in Cardiovascular Medicine Vol. 8 ( 2021-2-2)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 8 ( 2021-2-2)
    Abstract: Calcium dobesilate (CaD) is used effectively in patients with diabetic microvascular disorder, retinopathy, and nephropathy. Here we sought to determine whether it has an effect on cardiomyocytes calcium mishandling that is characteristic of diabetic cardiomyopathy. Cardiomyocytes were sterile isolated and cultured from 1 to 3 days neonatal rats and treated with vehicle (Control), 25 mM glucose+300 μM Palmitic acid (HG+PA), 100 μM CaD (CaD), or HG+PA+CaD to test the effects on calcium signaling (Ca 2+ sparks, transients, and SR loads) and reactive oxygen species (ROS) production by confocal imaging. Compared to Control, HG+PA treatment significantly reduced field stimulation-induced calcium transient amplitudes (2.22 ± 0.19 vs. 3.56 ± 0.21, p & lt; 0.01) and the levels of caffeine-induced calcium transients (3.19 ± 0.14 vs. 3.72 ± 0.15, p & lt; 0.01), however significantly increased spontaneous Ca 2+ sparks firing levels in single cardiomyocytes (spontaneous frequency 2.65 ± 0.23 vs. 1.72 ± 0.12, p & lt; 0.01) and ROS production (67.12 ± 4.4 vs. 47.65 ± 2.12, p & lt; 0.05), which suggest that HG+PA treatment increases the Spontaneity Ca 2+ spark frequency, and then induced partial reduction of SR Ca 2+ content and subsequently weaken systolic Ca 2+ transient in cardiomyocyte. Remarkably, these impairments in calcium signaling and ROS production were largely prevented by pre-treatment of the cells with CaD. Therefore, CaD may contribute to a good protective effect on patients with calcium mishandling and contractile dysfunction in cardiomyocytes associated with diabetic cardiomyopathy.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    DOI: 10.3389/fcvm.2021.637021
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2781496-8
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  • 4
    Online Resource
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    DataSheet1.doc
    Frontiers Media SA ; 2022
    In:  Frontiers in Bioengineering and Biotechnology Vol. 10 ( 2022-5-16)
    Details
    In: Frontiers in Bioengineering and Biotechnology, Frontiers Media SA, Vol. 10 ( 2022-5-16)
    Abstract: Patients who has been implanted with hip implant usually undergo revision surgery. The reason is that high stiff implants would cause non-physiological distribution loadings, which is also known as stress shielding, and finally lead to bone loss and aseptic loosening. Titanium implants are widely used in human bone tissues; however, the subsequent elastic modulus mismatch problem has become increasingly serious, and can lead to stress-shielding effects. This study aimed to develop a parametric design methodology of porous titanium alloy hip implant with gradient elastic modulus, and mitigate the stress-shielding effect. Four independent adjustable dimensions of the porous structure were parametrically designed, and the Kriging algorithm was used to establish the mapping relationship between the four adjustable dimensions and the porosity, surface-to-volume ratio, and elastic modulus. Moreover, the equivalent stress on the surface of the femur was optimized by response surface methodology, and the optimal gradient elastic modulus of the implant was obtained. Finally, through the Kriging approximation model and optimization results of the finite element method, the dimensions of each segment of the porous structure that could effectively mitigate the stress-shielding effect were determined. Experimental results demonstrated that the parameterized design method of the porous implant with gradient elastic modulus proposed in this study increased the strain value on the femoral surface by 17.1% on average. Consequently, the stress-shielding effect of the femoral tissue induced by the titanium alloy implant was effectively mitigated.
    Type of Medium: Online Resource
    ISSN: 2296-4185
    URL: Article
    URL: Article
    DOI: 10.3389/fbioe.2022.850184
    DOI: 10.3389/fbioe.2022.850184.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2719493-0
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  • 5
    Online Resource
    Online Resource
    Table2.xlsx
    Frontiers Media SA ; 2022
    In:  Frontiers in Physiology Vol. 13 ( 2022-5-9)
    Details
    In: Frontiers in Physiology, Frontiers Media SA, Vol. 13 ( 2022-5-9)
    Abstract: Diabetic cardiomyopathy (DCM) is one of the most essential cardiovascular complications in diabetic patients associated with glucose and lipid metabolism disorder, fibrosis, oxidative stress, and inflammation in cardiomyocytes. Despite increasing research on the molecular pathogenesis of DCM, it is still unclear whether metabolic pathways and alterations are probably involved in the development of DCM. This study aims to characterize the metabolites of DCM and to identify the relationship between metabolites and their biological processes or biological states through untargeted metabolic profiling. UPLC-MS/MS was applied to profile plasma metabolites from 78 patients with diabetes (39 diabetes with DCM and 39 diabetes without DCM as controls). A total of 2,806 biochemical were detected. Compared to those of DM patients, 78 differential metabolites in the positive-ion mode were identified in DCM patients, including 33 up-regulated and 45 down-regulated metabolites; however, there were only six differential metabolites identified in the negative mode including four up-regulated and two down-regulated metabolites. Alterations of several serum metabolites, including lipids and lipid-like molecules, organic acids and derivatives, organic oxygen compounds, benzenoids, phenylpropanoids and polyketides, and organoheterocyclic compounds, were associated with the development of DCM. KEGG enrichment analysis showed that there were three signaling pathways (metabolic pathways, porphyrin, chlorophyll metabolism, and lysine degradation) that were changed in both negative- and positive-ion modes. Our results demonstrated that differential metabolites and lipids have specific effects on DCM. These results expanded our understanding of the metabolic characteristics of DCM and may provide a clue in the future investigation of reducing the incidence of DCM. Furthermore, the metabolites identified here may provide clues for clinical management and the development of effective drugs.
    Type of Medium: Online Resource
    ISSN: 1664-042X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fphys.2022.863347
    DOI: 10.3389/fphys.2022.863347.s001
    DOI: 10.3389/fphys.2022.863347.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564217-0
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  • 6
    Online Resource
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    Creep-fatigue damage analysis of a large horizontal molten-salt storage tank
    IOP Publishing ; 2022
    In:  Journal of Physics: Conference Series Vol. 2256, No. 1 ( 2022-04-01), p. 012028-
    Details
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 2256, No. 1 ( 2022-04-01), p. 012028-
    Abstract: Molten-salt storage tank is the key equipment of solar-thermal storage system. In this paper, creep-fatigue analysis and evaluation were performed on a large horizontal molten-salt storage tank according to ASME Code Case 2843, and influence of the structural form for opening reinforcement was investigated. Results found that increasing the thickness of the tube was not very helpful for the equipment to pass creep-fatigue damage assessment; On the other hand, the integral reinforced structure was effective to meet the requirement of creep-fatigue damage assessment. For the horizontal molten-salt storage tank studied here, the creep damage was dominant compared to the fatigue damage.
    Type of Medium: Online Resource
    ISSN: 1742-6588 , 1742-6596
    URL: Article
    DOI: 10.1088/1742-6596/2256/1/012028
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 2166409-2
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  • 7
    Online Resource
    Online Resource
    DataSheet_1.docx
    Frontiers Media SA ; 2023
    In:  Frontiers in Immunology Vol. 14 ( 2023-1-30)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 14 ( 2023-1-30)
    Abstract: Sepsis is organ dysfunction due to the host’s deleterious response to infection, and the kidneys are one of the organs damaged in common sepsis. Sepsis-associated acute kidney injury (SA-AKI) increases the mortality in patients with sepsis. Although a substantial volume of research has improved the prevention and treatment of the disease, SA-SKI is still a significant clinical concern. Purpose Aimed to use weighted gene co-expression network analysis (WGCNA) and immunoinfiltration analysis to study SA-AKI-related diagnostic markers and potential therapeutic targets. Methods Immunoinfiltration analysis was performed on SA-AKI expression datasets from the Gene Expression Synthesis (GEO) database. A weighted gene co-expression network analysis (WGCNA) analysis was performed on immune invasion scores as trait data, and modules associated with immune cells of interest were identified as hub modules. Screening hub geneset in the hub module using protein-protein interaction (PPI) network analysis. The hub gene was identified as a target by intersecting with significantly different genes screened by differential expression analysis and validated using two external datasets. Finally, the correlation between the target gene, SA-AKI, and immune cells was verified experimentally. Results Green modules associated with monocytes were identified using WGCNA and immune infiltration analysis. Differential expression analysis and PPI network analysis identified two hub genes ( AFM and GSTA1 ). Further validation using additional AKI datasets GSE30718 and GSE44925 showed that AFM was significantly downregulated in AKI samples and correlated with the development of AKI. The correlation analysis of hub genes and immune cells showed that AFM was significantly associated with monocyte infiltration and hence, selected as a critical gene. In addition, Gene single-enrichment analysis (GSEA) and PPI analyses results showed that AFM was significantly related to the occurrence and development of SA-AKI. Conclusions AFM is inversely correlated with the recruitment of monocytes and the release of various inflammatory factors in the kidneys of AKI. AFM can be a potential biomarker and therapeutic target for monocyte infiltration in sepsis-related AKI.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2023.1049536
    DOI: 10.3389/fimmu.2023.1049536.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2606827-8
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  • 8
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    Research on 4D Simulation Technology of Reconstruction Engineering Construction Organization Based on BIM
    IOP Publishing ; 2020
    In:  IOP Conference Series: Earth and Environmental Science Vol. 568, No. 1 ( 2020-09-01), p. 012016-
    Details
    In: IOP Conference Series: Earth and Environmental Science, IOP Publishing, Vol. 568, No. 1 ( 2020-09-01), p. 012016-
    Abstract: This research is based on BIM technology to achieve 4D simulation of highway construction organization. By correlating BIM model and construction process, it can identify potential process errors or conflicts in advance, optimize construction organization process, and reduce unnecessary capital investment. Relying on the research results, the collaborative management of the quality, schedule and cost of complex projects in the construction process is realized.
    Type of Medium: Online Resource
    ISSN: 1755-1307 , 1755-1315
    URL: Article
    DOI: 10.1088/1755-1315/568/1/012016
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 2434538-6
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  • 9
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    Online Resource
    The role of EEG localized activation and CNS arousal in executive function performance in children with AD/HD
    Frontiers Media SA ; 2017
    In:  Frontiers in Human Neuroscience Vol. 11 ( 2017)
    Details
    In: Frontiers in Human Neuroscience, Frontiers Media SA, Vol. 11 ( 2017)
    Type of Medium: Online Resource
    ISSN: 1662-5161
    URL: Article
    DOI: 10.3389/conf.fnhum.2017.224.00023
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2017
    detail.hit.zdb_id: 2425477-0
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  • 10
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    Resveratrol Attenuates Early Brain Injury after Experimental Subarachnoid Hemorrhage via Inhibition of NLRP3 Inflammasome Activation
    Frontiers Media SA ; 2017
    In:  Frontiers in Neuroscience Vol. 11 ( 2017-11-03)
    Details
    In: Frontiers in Neuroscience, Frontiers Media SA, Vol. 11 ( 2017-11-03)
    Type of Medium: Online Resource
    ISSN: 1662-453X
    URL: Article
    DOI: 10.3389/fnins.2017.00611
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2017
    detail.hit.zdb_id: 2411902-7
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