In:
Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-12-20)
Abstract:
Emerging insights into iron-dependent form of regulated cell death ferroptosis in cancer have opened a perspective for its use in cancer therapy. Of interest, a systematic profiling of ferroptosis gene signatures as prognostic factors has gained special attention in several cancers. Herein, we sought to investigate the presence of repetitive genomes in the vicinity of ferroptosis genes that may influence their expression and to establish a prognostic gene signature associated with multiple myeloma (MM). Our analysis showed that genes associated with ferroptosis were enriched with the repetitive genome in their vicinity, with a strong predominance of the SINE family, followed by LINE, of which the most significant discriminant values were SINE/Alu and LINE/L1, respectively. In addition, we examined in detail the performance of these genes as a cancer risk prediction model and specified fourteen ferroptosis-related gene signatures, which identified MM high-risk patients with lower immune/stromal scores with higher tumor purity in their immune microenvironment. Of interest, we also found that lncRNA CRNDE correlated with a risk score and was highly associated with the majority of genes comprising the signature. Taken together, we propose to investigate the molecular impact of the repetitive genome we have highlighted on the local transcriptome of ferroptosis genes in cancer. Furthermore, we revealed a genomic signature/biomarker related to ferroptosis that can be used to predict the risk of survival in MM patients.
Type of Medium:
Online Resource
ISSN:
2234-943X
DOI:
10.3389/fonc.2022.1026153
DOI:
10.3389/fonc.2022.1026153.s001
DOI:
10.3389/fonc.2022.1026153.s002
DOI:
10.3389/fonc.2022.1026153.s003
DOI:
10.3389/fonc.2022.1026153.s004
DOI:
10.3389/fonc.2022.1026153.s005
DOI:
10.3389/fonc.2022.1026153.s006
DOI:
10.3389/fonc.2022.1026153.s007
DOI:
10.3389/fonc.2022.1026153.s008
DOI:
10.3389/fonc.2022.1026153.s009
DOI:
10.3389/fonc.2022.1026153.s010
DOI:
10.3389/fonc.2022.1026153.s011
DOI:
10.3389/fonc.2022.1026153.s012
DOI:
10.3389/fonc.2022.1026153.s013
DOI:
10.3389/fonc.2022.1026153.s014
DOI:
10.3389/fonc.2022.1026153.s015
DOI:
10.3389/fonc.2022.1026153.s016
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2649216-7
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