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  • 1
    Online Resource
    Online Resource
    Table1.XLSX
    Frontiers Media SA ; 2022
    In:  Frontiers in Pharmacology Vol. 12 ( 2022-1-28)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 12 ( 2022-1-28)
    Abstract: Psoriasis is a chronic and refractory inflammatory and autoimmune-mediated cutaneous disease affecting approximately 2%–3% of the global population. Most of the current therapies could relieve symptoms rapidly, while the side effects cannot be negligible. Hence, it is urgent to explore much safer and more effective treatments. In the current work, we evaluated the potential beneficial effect of Punica granatum peel polysaccharides (PPPs) in an imiquimod-elicited psoriasis-like mouse model and unraveled their mechanism of action. Firstly, PPPs were isolated from P. granatum peels, and then the molecular weight was determined and monosaccharide analysis was performed. The results revealed that PPPs significantly ameliorated psoriasis-like skin lesions and reduced the Psoriasis Area and Severity Index (PASI) scores and transepidermal water loss (TEWL). PPPs also attenuated the expressions of CD3 and Ki67 in psoriasis-like mouse skin and suppressed the serum or skin levels of pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), IL-1β, IL-8, IL-17, and IL-23. Moreover, PPPs were able to upregulate the mRNA and protein expressions of aquaporin-3 (AQP3) and filaggrin (FLG) in the skin of mice. In addition, PPPs inhibited the NF-κB and STAT3 signaling pathways. Overall, these results indicated that PPPs ameliorated the symptoms of psoriasis through inhibition of the inflammatory cytokines by suppressing the NF-κB and STAT3 signaling pathways and improved skin barrier protection via enhancing AQP3 and FLG. These observations potentially contribute to providing theoretical and experimental evidence for the clinical application of PPPs for psoriasis.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fphar.2021.806844
    DOI: 10.3389/fphar.2021.806844.s001
    DOI: 10.3389/fphar.2021.806844.s002
    DOI: 10.3389/fphar.2021.806844.s003
    DOI: 10.3389/fphar.2021.806844.s004
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 2
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    Online Resource
    Fuzhenghefuzhiyang Formula (FZHFZY) Improves Epidermal Differentiation via Suppression of the Akt/mTORC1/S6K1 Signalling Pathway in Psoriatic Models
    Frontiers Media SA ; 2021
    In:  Frontiers in Pharmacology Vol. 12 ( 2021-8-11)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 12 ( 2021-8-11)
    Abstract: Psoriasis is a chronic proliferative skin disorder characterised by abnormal epidermal differentiation. The Fuzhenghefuzhiyang (FZHFZY) formula created by Chuanjian Lu, a master of Chinese medicine in dermatology, has been external used in the Guangdong Provincial Hospital of Chinese Medicine for the treatment of psoriasis, but its mechanisms of action against psoriasis remain poorly understood. This study involved an exploration of the effects of FZHFZY on epidermal differentiation and its underlying mechanisms in interleukin (IL)-17A/IL-22/interferon (IFN)-γ/tumour necrosis factor (TNF)-α–stimulated HaCaT cells and in a mouse model of imiquimod (IMQ)-induced psoriasis. Cell viability was assessed by MTT assay. Epidermal differentiation was detected by reverse-transcription polymerase chain reaction and western blotting. Histological evaluation of the skin tissue was performed via haematoxylin and eosin staining, and the Akt/mTORC1/S6K1 pathway was analysed by western blotting. FZHFZY inhibited proliferation and improved epidermal differentiation in IL-17A/IL-22/IFN-γ/TNF-α–induced HaCaT cells. FZHFZY ameliorated symptoms of psoriasis, regulated epidermal differentiation and inhibited phosphorylation of the Akt/mTORC1/S6K1 pathway in the skin of mice with imiquimod-induced psoriasis. Our results suggest that FZHFZY may exhibit therapeutic action against psoriasis by regulating epidermal differentiation via inhibition of the Akt/mTORC1/S6K1 pathway.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    DOI: 10.3389/fphar.2021.650816
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 3
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    Online Resource
    Table_4.docx
    Frontiers Media SA ; 2021
    In:  Frontiers in Pediatrics Vol. 9 ( 2021-8-5)
    Details
    In: Frontiers in Pediatrics, Frontiers Media SA, Vol. 9 ( 2021-8-5)
    Abstract: Objective: The objective of this study is to further explore the difference between elevated blood pressure (EBP), elevated pulse pressure (EPP), and elevated mean arterial pressure (EMAP) and obesity in Chinese school-age children by sex. Methods: We performed a cross-sectional study of 935 children between 7 and 12 years old. Overweight and obesity were defined by body mass index and body composition. The multivariate logistic regression and the adjusted population attributable risk were used to assess the effects of obesity on pre-EBP/EBP, EPP, and EMAP. The interactions were used to identify the modification of obese on the relationship between related indicators of blood pressure and height or age. Results: The average age of the children included in the study was 10. Boys with overweight and obesity had higher pre-EBP/EBP, EPP, and EMAP ( p & lt; 0.05). The multivariate logistic regression analysis showed that overweight and obesity had a greater impact on BP and MAP than PP, especially in boys [odds ratio (OR) & gt; 1]. Pre-EBP/EBP in 79% of boys and 76% of girls could be attributable to the visceral fat level. The interaction between BP, PP, MAP, and height or age was modestly increased in children with overweight and obesity, especially in boys. Conclusions: Independent of age and height, obesity not only increases blood pressure, it also increases mean arterial pressure and pulse pressure, and this effect is more pronounced in boys.
    Type of Medium: Online Resource
    ISSN: 2296-2360
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fped.2021.674504
    DOI: 10.3389/fped.2021.674504.s001
    DOI: 10.3389/fped.2021.674504.s002
    DOI: 10.3389/fped.2021.674504.s003
    DOI: 10.3389/fped.2021.674504.s004
    DOI: 10.3389/fped.2021.674504.s005
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2711999-3
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  • 4
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    Online Resource
    Development of a piston-actuated 3D bio-printer with performance prediction system for the reliable printing of tubular structures
    IOP Publishing ; 2023
    In:  Journal of Micromechanics and Microengineering
    Details
    In: Journal of Micromechanics and Microengineering, IOP Publishing
    Abstract: 3D bio-printing is a promising approach for creating tubular structures within the human body by precisely controlling the distribution of cells. While several 3D bio-printers have been developed for printing tubular structures, achieving reliable and repeatable construction of effective human tubular structures remains a challenge. This paper presents a piston-actuated 3D bio-tubular structures printer that uses a rotary rod-support printing method and a printing performance prediction system.The printing performance prediction system is based on a two-phase flow computational fluid dynamics (CFD) model that simulates the tubular structure forming process and provides optimal printing setup parameters, such as extrusion nozzle movement speed, nozzle height, and rod rotating speed. Experimental testing has validated the performance prediction system, which achieved a fair prediction accuracy with an average error of around 10%.The proposed bio-printer and prediction system have the potential to improve the efficiency and effectiveness of tubular structure printing for various biomedical applications.
    Type of Medium: Online Resource
    ISSN: 0960-1317 , 1361-6439
    URL: Article
    DOI: 10.1088/1361-6439/acf7cd
    RVK:
    ZG 1100
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 1480280-6
    detail.hit.zdb_id: 1069644-1
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  • 5
    Online Resource
    Online Resource
    Direct and reverse overwrite processes in perpendicular recording
    Institute of Electrical and Electronics Engineers (IEEE) ; 2006
    In:  IEEE Transactions on Magnetics Vol. 42, No. 2 ( 2006-02), p. 151-156
    Details
    In: IEEE Transactions on Magnetics, Institute of Electrical and Electronics Engineers (IEEE), Vol. 42, No. 2 ( 2006-02), p. 151-156
    Type of Medium: Online Resource
    ISSN: 0018-9464
    URL: Article
    DOI: 10.1109/TMAG.2005.861773
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2006
    detail.hit.zdb_id: 2025397-7
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  • 6
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    Optimization of the co-axial dispensing nozzle of a 3D bioprinter for the fabrication of tubular structures with micro-channel encapsulation
    IOP Publishing ; 2021
    In:  Journal of Micromechanics and Microengineering Vol. 31, No. 4 ( 2021-04-01), p. 045009-
    Details
    In: Journal of Micromechanics and Microengineering, IOP Publishing, Vol. 31, No. 4 ( 2021-04-01), p. 045009-
    Abstract: The 3D bio-printing has been developed as an effective approach to artificially create tubular tissue structures, which have been frequently found in body and organ systems. China Agricultural University (CAU) has developed a laboratory 3D bio-printer that can create tubular structures with the encapsulation of microfluidic channel. In order to create a tubular structure with more effective micro-channel encapsulation for better nutrient delivery and chemical stimulation, this work presents a design optimization of co-axial dispensing nozzle of this 3D bio-printer. In this study, an experimentally validated two-phase flow computational fluid dynamics modeling tool based on ANSYS CFX has been developed to analyze the microfluidic domain of fluid channels inside the nozzle. The simulations on the extrusion and encapsulation process of bio-inks have been conducted. Based on the response surface method, the simulation work has established an equation to predict the volume fraction of the encapsulating layer against a variety of influencing factors including the size of extrusion nozzle, pneumatic pressure condition and the dynamic viscosity of the bio-ink. This equation has been used to recommend optimal solutions of printing parameters for the CAU bio-printer, which is expected to improve the quality of bio-printed tubular structure with an encapsulation.
    Type of Medium: Online Resource
    ISSN: 0960-1317 , 1361-6439
    URL: Article
    DOI: 10.1088/1361-6439/abe09a
    RVK:
    ZG 1100
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2021
    detail.hit.zdb_id: 1480280-6
    detail.hit.zdb_id: 1069644-1
    Location Call Number Limitation Availability
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