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  • 1
    Online Resource
    Online Resource
    Analysis of a piezoelectric power harvester with adjustable frequency by precise electric field method
    Institute of Electrical and Electronics Engineers (IEEE) ; 2013
    In:  IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control Vol. 60, No. 10 ( 2013-10), p. 2154-2161
    Details
    In: IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Institute of Electrical and Electronics Engineers (IEEE), Vol. 60, No. 10 ( 2013-10), p. 2154-2161
    Type of Medium: Online Resource
    ISSN: 0885-3010
    URL: Article
    DOI: 10.1109/TUFFC.2013.2806
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2013
    detail.hit.zdb_id: 2039931-5
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  • 2
    Online Resource
    Online Resource
    DataSheet1.DOCX
    Frontiers Media SA ; 2023
    In:  Frontiers in Pharmacology Vol. 14 ( 2023-2-16)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 14 ( 2023-2-16)
    Abstract: Background: A. chinense frequently used in Miao medicine to treat rheumatic diseases. However, as a famous toxic herb, Alangium chinense and its representative components exhibit ineluctable neurotoxicity, thus creating significant challenges for clinical application. The combined application with compatible herbs in Jin-Gu-Lian formula attenuates such neurotoxicity according to the compatible principle of traditional Chinese medicines. Purpose: We aimed to investigate the detoxification of the compatible herbs in Jin-Gu-Lian formula on A. chinense -induced neurotoxicity and investigate its mechanism. Methods: Neurobehavioral and pathohistological analysis were used to determine the neurotoxicity in rats administered with A. chinense extract (AC), extract of compatible herbs in Jin-Gu-Lian formula (CH) and combination of AC with CH for 14 days. The mechanism underlying the reduction of toxicity by combination with CH was assessed by enzyme-linked immunosorbent assays, spectrophotometric assays, liquid chromatography tandem-mass spectrometry and real-time reverse transcription-quantitative polymerase chain reaction. Results: Compatible herbs attenuated the AC-induced neurotoxicity as evidenced by increased locomotor activity, enhanced grip strength, the decreased frequency of AC-induced morphological damage in neurons, as well as a reduction of neuron-specific enolase (NSE) and neurofilament light chain (NEFL) levels. The combination of AC and CH ameliorated AC-induced oxidative damage by modulating the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and total antioxidant capacity (T-AOC). AC treatment significantly reduced the levels of monoamine and acetylcholine neurotransmitters in the brains of rats, including acetylcholine (Ach), dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), norepinephrine (NE), and serotonin (5-HT). Combined AC and CH treatment regulated the abnormal concentrations and metabolisms of neurotransmitters. Pharmacokinetic studies showed that the co-administration of AC and CH significantly decreased plasma exposure levels of two main components of AC, as evidenced by the reduction of maximum plasma concentration (C max ), area under the plasma concentration-time curve (AUC) compared to AC. In addition, the AC-induced downregulation in mRNA expression of cytochrome P450 enzymes was significantly reduced in response to combined AC and CH treatment. Conclusion: Compatible herbs in Jin-Gu-Lian formula alleviated the neurotoxicity induced by A. chinense by ameliorating oxidative damage, preventing abnormality of neurotransmitters and modulating pharmacokinetics.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    URL: Article
    DOI: 10.3389/fphar.2023.1133982
    DOI: 10.3389/fphar.2023.1133982.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 3
    Online Resource
    Online Resource
    A novel energetic cocrystal composed of CL-20 and 1-methyl-2,4,5-trinitroimidazole with high energy and low sensitivity
    International Union of Crystallography (IUCr) ; 2022
    In:  Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials Vol. 78, No. 2 ( 2022-04-01), p. 133-139
    Details
    In: Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials, International Union of Crystallography (IUCr), Vol. 78, No. 2 ( 2022-04-01), p. 133-139
    Abstract: A cocrystal explosive comprising 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) and 1-methyl-2,4,5-trinitroimidazole (MTNI) (molar ratio, 1:1) was synthesized. The structure of the cocrystal was characterized by single-crystal X-ray diffraction. Its structure was further determined by powder X-ray diffraction, infrared spectroscopy and differential scanning calorimetry which showed that its morphology was different from the morphology of the mechanical mixture of two raw materials. The decomposition temperature of the cocrystal is lower than that of CL-20 and MTNI. The calculated detonation performance is slightly lower than that of HMX, but the cocrystal has excellent sensitivity performance relative to that of CL-20, even lower than that of RDX. These features make this cocrystal ideal to be used in applications with low-sensitivity requirements.
    Type of Medium: Online Resource
    ISSN: 2052-5206
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.1107/S2052520622000245
    DOI: 10.1107/S2052520622000245/yv5003sup1.cif
    DOI: 10.1107/S2052520622000245/yv5003Isup2.hkl
    DOI: 10.1107/S2052520622000245/yv5003sup3.pdf
    Language: Unknown
    Publisher: International Union of Crystallography (IUCr)
    Publication Date: 2022
    detail.hit.zdb_id: 2020841-8
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  • 4
    Online Resource
    Online Resource
    Fibulin-2 inhibits development of gastric cancer by downregulating β-catenin
    Spandidos Publications ; 2019
    In:  Oncology Letters ( 2019-07-10)
    Details
    In: Oncology Letters, Spandidos Publications, ( 2019-07-10)
    Type of Medium: Online Resource
    ISSN: 1792-1074 , 1792-1082
    URL: Journal
    URL: Article
    DOI: 10.3892/ol
    DOI: 10.3892/ol.2019.10599
    Language: Unknown
    Publisher: Spandidos Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2573196-8
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