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  • 1
    Online Resource
    Online Resource
    Strategies Developed by Toxoplasma gondii to Survive in the Host
    Frontiers Media SA ; 2019
    In:  Frontiers in Microbiology Vol. 10 ( 2019-4-26)
    Details
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 10 ( 2019-4-26)
    Type of Medium: Online Resource
    ISSN: 1664-302X
    URL: Article
    DOI: 10.3389/fmicb.2019.00899
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2019
    detail.hit.zdb_id: 2587354-4
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  • 2
    Online Resource
    Online Resource
    Image iterative method for handwritten Chinese character recognition
    IOP Publishing ; 2020
    In:  Journal of Physics: Conference Series Vol. 1684, No. 1 ( 2020-11-01), p. 012101-
    Details
    In: Journal of Physics: Conference Series, IOP Publishing, Vol. 1684, No. 1 ( 2020-11-01), p. 012101-
    Abstract: Although accuracy and calculation time of handwritten Chinese character recognition have been greatly improved, it has not yet reached the practical application standard. Recently literatures, iterative method is used to recognize face images and good results are obtained. Therefore, image recognition is improved based on this idea. In this paper, linear combination of trigonometric functions is used as auxiliary function and image to construct discrete dynamic system. By adding bevel and shift to construct font surface and so on, the system structure is improved to solve problem of system convergence caused by large area flatness of handwritten Chinese character image, and good recognition effect is achieved. Preliminary experiments(for example, extracting 20 Chinese characters written by 9 people in the data set) are carried out, and recognition rate can reach 100% when all of them are trained, and recognition rate can reach 76.7% when each Chinese character is trained to 3 pieces; in addition, experiments were conducted on handwritten Chinese character sets changing from different angles, and the recognition rate reached 80%, which was compared with other algorithms to verify the feasibility of handwritten Chinese character recognition algorithm based on chaotic iterative trajectory characteristics of images.
    Type of Medium: Online Resource
    ISSN: 1742-6588 , 1742-6596
    URL: Article
    DOI: 10.1088/1742-6596/1684/1/012101
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 2166409-2
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  • 3
    Online Resource
    Online Resource
    Data_Sheet_2.xlsx
    Frontiers Media SA ; 2021
    In:  Frontiers in Genetics Vol. 12 ( 2021-7-23)
    Details
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 12 ( 2021-7-23)
    Abstract: The epigenetic regulation of gene expression is implicated in complex diseases in humans and various phenotypes in other species. There has been little exploration of regulatory elements in the pig. Here, we performed chromatin immunoprecipitation coupled with high-throughput sequencing (ChIP-Seq) to profile histone H3 lysine 4 trimethylation (H3K4me3) and histone H3 lysine 27 acetylation (H3K27ac) in the pituitary gland of adult Bama Xiang and Large White pigs, which have divergent evolutionary histories and large phenotypic differences. We identified a total of 65,044 non-redundant regulatory regions, including 23,680 H3K4me3 peaks and 61,791 H3K27ac peaks (12,318 proximal and 49,473 distal), augmenting the catalog of pituitary regulatory elements in pigs. We found 793 H3K4me3 and 3,602 H3K27ac peaks that show differential activity between the two breeds, overlapping with genes involved in the Notch signaling pathway, response to growth hormone (GH), thyroid hormone signaling pathway, and immune system, and enriched for binding motifs of transcription factors (TFs), including JunB, ATF3, FRA1, and BATF. We further identified 2,025 non-redundant super enhancers from H3K27ac ChIP-seq data, among which 302 were shared in all samples of cover genes enriched for biological processes related to pituitary function. This study generated a valuable dataset of H3K4me3 and H3K27ac regions in porcine pituitary glands and revealed H3K4me3 and H3K27ac peaks with differential activity between Bama Xiang and Large White pigs.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fgene.2021.697994
    DOI: 10.3389/fgene.2021.697994.s001
    DOI: 10.3389/fgene.2021.697994.s002
    DOI: 10.3389/fgene.2021.697994.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2606823-0
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  • 4
    Online Resource
    Online Resource
    Re-burying Artificially Exposed Surface of Viral Subunit Vaccines Through Oligomerization Enhances Vaccine Efficacy
    Frontiers Media SA ; 2022
    In:  Frontiers in Cellular and Infection Microbiology Vol. 12 ( 2022-6-29)
    Details
    In: Frontiers in Cellular and Infection Microbiology, Frontiers Media SA, Vol. 12 ( 2022-6-29)
    Abstract: Viral subunit vaccines often suffer low efficacy. We recently showed that when taken out of the context of whole virus particles, recombinant subunit vaccines contain artificially exposed surface regions that are non-neutralizing and reduce their efficacy, and thus these regions need to be re-buried in vaccine design. Here we used the envelope protein domain III (EDIII) of Japanese encephalitis virus (JEV), a subunit vaccine candidate, to further validate this important concept for subunit vaccine designs. We constructed monomeric EDIII, dimeric EDIII via a linear space, dimeric EDIII via an Fc tag, and trimeric EDIII via a foldon tag. Compared to monomeric EDIII or linearly linked dimeric EDIII, tightly packed EDIII oligomers via the Fc or foldon tag induce higher neutralizing antibody titers in mice and also protect mice more effectively from lethal JEV challenge. Structural analyses demonstrate that part of the artificially exposed surface areas on recombinant EDIII becomes re-buried in Fc or foldon-mediated oligomers. This study further establishes the artificially exposed surfaces as an intrinsic limitation of subunit vaccines, and suggests that re-burying these surfaces through tightly packed oligomerization is a convenient and effective approach to overcome this limitation.
    Type of Medium: Online Resource
    ISSN: 2235-2988
    URL: Article
    DOI: 10.3389/fcimb.2022.927674
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2619676-1
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  • 5
    Online Resource
    Online Resource
    Optimization of the co-axial dispensing nozzle of a 3D bioprinter for the fabrication of tubular structures with micro-channel encapsulation
    IOP Publishing ; 2021
    In:  Journal of Micromechanics and Microengineering Vol. 31, No. 4 ( 2021-04-01), p. 045009-
    Details
    In: Journal of Micromechanics and Microengineering, IOP Publishing, Vol. 31, No. 4 ( 2021-04-01), p. 045009-
    Abstract: The 3D bio-printing has been developed as an effective approach to artificially create tubular tissue structures, which have been frequently found in body and organ systems. China Agricultural University (CAU) has developed a laboratory 3D bio-printer that can create tubular structures with the encapsulation of microfluidic channel. In order to create a tubular structure with more effective micro-channel encapsulation for better nutrient delivery and chemical stimulation, this work presents a design optimization of co-axial dispensing nozzle of this 3D bio-printer. In this study, an experimentally validated two-phase flow computational fluid dynamics modeling tool based on ANSYS CFX has been developed to analyze the microfluidic domain of fluid channels inside the nozzle. The simulations on the extrusion and encapsulation process of bio-inks have been conducted. Based on the response surface method, the simulation work has established an equation to predict the volume fraction of the encapsulating layer against a variety of influencing factors including the size of extrusion nozzle, pneumatic pressure condition and the dynamic viscosity of the bio-ink. This equation has been used to recommend optimal solutions of printing parameters for the CAU bio-printer, which is expected to improve the quality of bio-printed tubular structure with an encapsulation.
    Type of Medium: Online Resource
    ISSN: 0960-1317 , 1361-6439
    URL: Article
    DOI: 10.1088/1361-6439/abe09a
    RVK:
    ZG 1100
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2021
    detail.hit.zdb_id: 1480280-6
    detail.hit.zdb_id: 1069644-1
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  • 6
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    Multi-Objective Workflow Scheduling With Deep-Q-Network-Based Multi-Agent Reinforcement Learning
    Institute of Electrical and Electronics Engineers (IEEE) ; 2019
    In:  IEEE Access Vol. 7 ( 2019), p. 39974-39982
    Details
    In: IEEE Access, Institute of Electrical and Electronics Engineers (IEEE), Vol. 7 ( 2019), p. 39974-39982
    Type of Medium: Online Resource
    ISSN: 2169-3536
    URL: Journal
    URL: Article
    DOI: 10.1109/Access.6287639
    DOI: 10.1109/ACCESS.2019.2902846
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2019
    detail.hit.zdb_id: 2687964-5
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  • 7
    Online Resource
    Online Resource
    Micromixing Characteristics in an Aerated Stirred Tank with Half Elliptical Blade Disk Turbine
    Walter de Gruyter GmbH ; 2014
    In:  International Journal of Chemical Reactor Engineering Vol. 12, No. 1 ( 2014-01-1), p. 231-243
    Details
    In: International Journal of Chemical Reactor Engineering, Walter de Gruyter GmbH, Vol. 12, No. 1 ( 2014-01-1), p. 231-243
    Abstract: The parallel-competing iodide-iodate reaction scheme was used to investigate the micromixing efficiency in an aerated stirred tank of 0.30 m diameter agitated by a half elliptical blade disk turbine. The mean specific energy dissipation rate P m ranged from 0.5 to 2.2 W/kg, while the superficial gas velocity V S ranged from 0.015 to 0.047 m/s. Four sub-surface feed positions were considered. When the tank is fed just under the liquid surface or in the near-wall region, the micromixing efficiency can be enhanced by introducing gases with superficial gas velocities higher than 0.031 m/s. The effects of gas on the micromixing performance become complicated, while the tank is fed in the impeller discharging region. The increase of gas flow rate does not always have good effects on the micromixing performance. Moreover, the way to feed sulfuric acid can strongly affect the efficiency of the reaction scheme. For a single liquid phase, the micromixing time t m according to the incorporation model varies from 5 × 10 −3 to 3 × 10 −2 s. The dimensionless local specific energy dissipation rate Φ near the liquid surface is almost independent of P m , while Φ in the impeller discharging area decreases with increasing P m .
    Type of Medium: Online Resource
    ISSN: 2194-5748 , 1542-6580
    URL: Article
    DOI: 10.1515/ijcre-2012-0097
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2014
    detail.hit.zdb_id: 2112754-2
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  • 8
    Online Resource
    Online Resource
    AC power analysis for second-order memory elements
    Frontiers Media SA ; 2023
    In:  Frontiers in Physics Vol. 11 ( 2023-2-17)
    Details
    In: Frontiers in Physics, Frontiers Media SA, Vol. 11 ( 2023-2-17)
    Abstract: As the product of a circuit’s voltage and current, apparent power ( S ) is of paramount necessity and importance in electrical utilities, electronics, communication, and neural network systems. Based on the existing AC power analysis on the two-terminal passive elements (i.e., R , L , and C ), some in-depth research on AC apparent power calculations for second-order memory elements and memristive systems is introduced to help with revealing their complex and unique non-linear phenomena. This paper derives the forms of real power, reactive power, and apparent power for the proposed second-order memory elements (i.e., MR , MC , and ML ) and reveals the difference between ideal memory elements and traditional passive ones (i.e., R , C , and L ). For all involved memory elements, harmonic values and an extra term occur in the expression of powers to represent their memory characteristics. Especially, the real power is a function of a circuit’s dissipative elements (usually resistances R ), but not exactly the memristor ( MR ). Then, the corresponding curves could be depicted, which demonstrate the differences between R / C / L and MR / MC / ML and verified that harmonic values existed in S MR / S MC / S ML , meaning that it would perpetually supply energy when operated with an alternating current.
    Type of Medium: Online Resource
    ISSN: 2296-424X
    URL: Article
    DOI: 10.3389/fphy.2023.1135739
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2721033-9
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  • 9
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    Online Resource
    A Shuttling Protein Kank1 Plays Important Role in the Sex Determination in Yellow Drum
    Frontiers Media SA ; 2022
    In:  Frontiers in Marine Science Vol. 9 ( 2022-5-4)
    Details
    In: Frontiers in Marine Science, Frontiers Media SA, Vol. 9 ( 2022-5-4)
    Abstract: Sex is one of the most important scientific topics, and the existence of sex dimorphism is a conserved feature in vertebrate taxa. The research on sex-determining genes and sex chromosome evolution is a hot topic in biology. The majority of sex-determining genes expressed in somatic cells, and reciprocal interactions between germ cells and somatic cells, are important for gonadal differentiation. However, the knowledge of how signals are transmitted between somatic cells and germ cells remains unclear. In this study, we confirmed the 36 dph was a sex determination critical stage in yellow drum through transcriptome analysis at the early development stages. We further found that Kank1 participated in the germ cells’ motility process in yellow drum through KEGG pathway analysis together with protein-protein interaction network. With the dual-luciferase reporter assay, we detected that Kank1 increased the transcription of dmrt1_Luc gene in CHO cells and 293T cells. Additionally, we observed that Kank1 was not only expressed in the cytoplasm but also in the nucleus in CHO cells through a fluorescence microscope. These results suggest that Kank1 acts as a shuttling protein as in humans and may play a difunctional role at the early gonad development stage in yellow drum, and it not only participated in the germ cells’ motility but also increased the expression of dmrt1 in yellow drum.
    Type of Medium: Online Resource
    ISSN: 2296-7745
    URL: Article
    DOI: 10.3389/fmars.2022.897004
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2757748-X
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  • 10
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    Online Resource
    Recent progresses in microfabricating perfluorinated polymers (Teflons) and the associated new applications in microfluidics
    AME Publishing Company ; 2018
    In:  Microphysiological Systems Vol. 1 ( 2018), p. 1-1
    Details
    In: Microphysiological Systems, AME Publishing Company, Vol. 1 ( 2018), p. 1-1
    Type of Medium: Online Resource
    ISSN: 2616-275X
    URL: Journal
    URL: Article
    DOI: 10.21037/mps
    DOI: 10.21037/mps.2018.08.02
    Language: Unknown
    Publisher: AME Publishing Company
    Publication Date: 2018
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