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  • 1
    Online Resource
    Online Resource
    ACTIV SARS-CoV-2 registry (Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult Patients). Assessment of impact of combined original comorbid diseases in patients with COVID-19 on the prognosis
    Consilium Medicum ; 2022
    In:  Terapevticheskii arkhiv Vol. 94, No. 1 ( 2022-01-15), p. 32-47
    Details
    In: Terapevticheskii arkhiv, Consilium Medicum, Vol. 94, No. 1 ( 2022-01-15), p. 32-47
    Abstract: Aim. Study the impact of various combinations of comorbid original diseases in patients infected with COVID-19 later on the disease progression and outcomes of the new coronavirus infection. Materials and methods. The ACTIV registry was created on the Eurasian Association of Therapists initiative. 5,808 patients have been included in the registry: men and women with COVID-19 treated at hospital or at home. ClinicalTrials.gov ID NCT04492384. Results. Most patients with COVID-19 have original comorbid diseases (oCDs). Polymorbidity assessed by way of simple counting of oCDs is an independent factor in negative outcomes of COVID-19. Search for most frequent combinations of 2, 3 and 4 oCDs has revealed absolute domination of cardiovascular diseases (all possible variants). The most unfavorable combination of 2 oCDs includes atrial hypertension (AH) and chronic heart failure (CHF). The most unfavorable combination of 3 oCDs includes AH, coronary heart disease (CHD) and CHF; the worst combination of 4 oCDs includes AH, CHD, CHF and diabetes mellitus. Such combinations increased the risk of lethal outcomes 3.963, 4.082 and 4.215 times respectively. Conclusion. Polymorbidity determined by way of simple counting of diseases may be estimated as a factor in the lethal outcome risk in the acute phase of COVID-19 in real practice. Most frequent combinations of 2, 3 and 4 diseases in patients with COVID-19 primarily include cardiovascular diseases (AH, CHD and CHF), diabetes mellitus and obesity. Combinations of such diseases increase the COVID-19 lethal outcome risk.
    Type of Medium: Online Resource
    ISSN: 2309-5342 , 0040-3660
    URL: Article
    DOI: 10.26442/00403660.2022.01.201320
    Language: Unknown
    Publisher: Consilium Medicum
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    ORGANIZATION OF THE TEACHING OF PSYCHOLOGY IN LARGE GROUPS
    Astrakhan State University ; 2017
    In:  HUMANITARIAN RESEARCHES Vol. 61, No. 1 ( 2017), p. 097-105
    Details
    In: HUMANITARIAN RESEARCHES, Astrakhan State University, Vol. 61, No. 1 ( 2017), p. 097-105
    Type of Medium: Online Resource
    ISSN: 1818-4936
    Uniform Title: ОРГАНИЗАЦИЯ ПРОЦЕССА ПРЕПОДАВАНИЯ ПСИХОЛОГИИ В БОЛЬШИХ ПОТОКАХ
    URL: Article
    DOI: 10.21672/1818-4936-2017-61-1-097-105
    Language: Unknown
    Publisher: Astrakhan State University
    Publication Date: 2017
    SSG: 7,39
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  • 3
    Online Resource
    Online Resource
    Features of the development of linguistic and communication competences of future foreign language teachers
    Scientific and Literature Open Access Publishing ; 2021
    In:  Linguistics and Culture Review Vol. 5, No. S2 ( 2021-07-15), p. 36-57
    Details
    In: Linguistics and Culture Review, Scientific and Literature Open Access Publishing, Vol. 5, No. S2 ( 2021-07-15), p. 36-57
    Abstract: The relevance of the study is determined by the fact that the professional competence of a teacher constitutes a dynamic combination of knowledge, abilities and practical skills, ways of thinking, professional, ideological and civic qualities, moral and ethical values. The linguistic competence of the teacher depends entirely on the possibilities of professional growth and the dynamics of the development of professional and communicative competences. The novelty of the study is determined by the fact that in professional activity the teacher acts as an active subject of communication: transmits and accepts information from students, colleagues and parents, strives for the maximum realisation of the abilities of each student and ensuring their emotional comfort. The authors of this study have determined that one of the primary tasks of higher pedagogical education lies in the development of professional and pedagogical communicative competence of a teacher. The practical significance of the study is determined by the fact that professional and pedagogical communicative competence acts as a spiritual and moral factor and the scientific content of the educational process, where a major role is played by the teacher's knowledge, humanity, spiritual generosity, as well as the desire to understand and help the student.
    Type of Medium: Online Resource
    ISSN: 2690-103X
    URL: Issue
    URL: Article
    DOI: 10.21744/lingcure.v5nS2.2021
    DOI: 10.21744/lingcure.v5nS2.1329
    Language: Unknown
    Publisher: Scientific and Literature Open Access Publishing
    Publication Date: 2021
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  • 4
    Online Resource
    Online Resource
    DataSheet_1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Immunology Vol. 13 ( 2022-11-16)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-11-16)
    Abstract: WHO has declared the outbreak of monkeypox as a public health emergency of international concern. In less than three months, monkeypox was detected in more than 30 000 people and spread to more than 80 countries around the world. It is believed that the immunity formed to smallpox vaccine can protect from monkeypox infection with high efficiency. The widespread use of Vaccinia virus has not been carried out since the 1980s, which raises the question of the level of residual immunity among the population and the identification of groups requiring priority vaccination. We conducted a cross-sectional serological study of remaining immunity among Moscow residents. To do this, a collection of blood serum samples of age group over 30 years old was formed, an in-house ELISA test system was developed, and a virus neutralization protocol was set up. Serum samples were examined for the presence of IgG antibodies against Vaccinia virus ( n =2908), as well as for the ability to neutralize plaque formation with a Vaccinia virus MNIIVP-10 strain ( n =299). The results indicate the presence of neutralizing antibody titer of 1/20 or more in 33.3 to 53.2% of people older than 45 years. Among people 30-45 years old who probably have not been vaccinated, the proportion with virus neutralizing antibodies ranged from 3.2 to 6.7%. Despite the higher level of antibodies in age group older than 66 years, the proportion of positive samples in this group was slightly lower than in people aged 46-65 years. The results indicate the priority of vaccination in groups younger than 45, and possibly older than 66 years to ensure the protection of the population in case of spread of monkeypox among Moscow residents. The herd immunity level needed to stop the circulation of the virus should be at least 50.25 – 65.28%.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2022.1023164
    DOI: 10.3389/fimmu.2022.1023164.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606827-8
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  • 5
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    Online Resource
    Fig. 3. Distribution of cases of breakthrough infections by timing of occurrence after vaccination
    ECO-Vector LLC ; 2022
    In:  Russian Family Doctor Vol. 26, No. 1 ( 2022-04-29), p. 21-26
    Details
    In: Russian Family Doctor, ECO-Vector LLC, Vol. 26, No. 1 ( 2022-04-29), p. 21-26
    Abstract: BACKGROUND: Vaccination is currently considered the most successful strategy against the SARS-CoV-2 virus. However, cases of infection despite vaccination, so-called breakthrough infections, have been reported worldwide. AIM: To evaluate the impact of vaccination against the new coronavirus infection COVID-19 on the morbidity of university students. MATERIALS AND METHODS: The incidence of new coronavirus infection (COVID-19) among the students of North-Western State Medical University named after I.I. Mechnikov (further University) from September 1 to December 15, 2020 and 2021 was analyzed. There were 4876 and 4681 students under observation. Data on vaccination, probable site of transmission infection were collected by interviewing the ill people. Statistical processing of data was performed using EpiInfo software. RESULTS: For the analyzed period 191 cases of COVID-19 among students were detected, the incidence of COVID-19 was 4.08 per 100 students, for the same period of the academic year 2020 it was 5.50, despite the fact that the incidence among St. Petersburg residents in 2021 was 1.75 times higher than in 2020. Re-infection was detected in 35 (18.3%) cases, 18 of whom were also vaccinated against COVID-19. A probable place of transmission infection was established in 36.1% of the cases, the most frequent being contact with a patient at their place of work in a health-care facility. By December 15, 2021, a total of 62.8% of students had been vaccinated against COVID-19. The incidence among vaccinated students was 2.72 per 100 students and 4.94 per 100 among unvaccinated students. A risk factor for breakthrough infections after vaccination was close contact with the source of infection: vaccinated persons had close contact in 50% of cases, compared with 28.9% of unvaccinated persons. The most important were contact with a patient in a health care setting and having multiple sources of infection, 31.1% and 5.6%, respectively. CONCLUSIONS: Vaccination against COVID-19 was an effective preventive intervention. A risk factor for disease after vaccination is close contact with the source of infection. Establishment of collective immunity after vaccination is decisive for the vaccination-to-disease ratio, which starts to develop with 70-80% of vaccinated individuals. The use of a mask in public places and social distancing remain important preventive measures.
    Type of Medium: Online Resource
    ISSN: 2713-2331 , 2072-1668
    URL: Issue
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.17816/RFD.20221
    DOI: 10.17816/RFD99623
    DOI: 10.17816/RFD99623-63015
    DOI: 10.17816/RFD99623-63016
    DOI: 10.17816/RFD99623-63017
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
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  • 6
    Online Resource
    Online Resource
    Problems in ensuring effective parasitological control on the territory of the Russian Federation
    Federal Scientific Center for Hygiene F.F.Erisman ; 2022
    In:  Hygiene and sanitation Vol. 101, No. 8 ( 2022-09-14), p. 896-903
    Details
    In: Hygiene and sanitation, Federal Scientific Center for Hygiene F.F.Erisman, Vol. 101, No. 8 ( 2022-09-14), p. 896-903
    Abstract: Introduction. Modern parasitology is an area of interdisciplinary research that uses the methods and approaches of various biological disciplines, such as genomics, proteomics, bioinformatics, ecology, biology, medicine, veterinary medicine, climatology, using methods of landscape-geographical mapping, mathematical modeling to assess the parasitological situation and predict its dynamics. New problems associated with the parasitic aspects of global climate change, the introduction of new host species and parasites (pathogens), and anthropogenic transformation of natural ecosystems become topical. In this regard, the primary tasks for optimizing the socio-hygienic monitoring of the parasitic safety of the environment is the introduction of new methodological approaches for ranking territories - the risk according to the species composition and intensity of circulation of pathogens of parasitic diseases, the trend in changes in their range of pathogens and epidemiological properties in anthropogenically determined conditions. The purpose of the study is to substantiate the methodology for choosing a territory for optimizing social and hygienic monitoring and substantiating proposals for the unification of hygienic standards for parasitological indicators of environmental safety. Materials and methods. Experimental parasitological monitoring was carried out at the pilot site. 712 samples were studied using unified methods of parasitological research of biomaterial (MUK 4.2.3145-13 “Laboratory diagnostics of helminthiases and protozooses”) and environmental objects (MUK 4.2.2661-10 “Methods of sanitary and parasitological research”). Results. Data were obtained on the high intensity of the circulation of pathogens of parasitic diseases in the environment - 25%. More than 15 types of pathogens of parasitic diseases have been systematized. Limitations. The limitations of the study were associated with the lack of development of diagnostic tools for the genetic identification of parasitic pathogens within the same systematic group by PCR analysis. Conclusion. Methodological disagreements in various normative documents to the composition of the “target indicators” of research are determined. The practical part of the work included the collection of material from people and animals, from environmental objects. A new approach to the hygienic standardization of parasitological indicators based on group systematization of the propagative stages of development of parasites with subsequent methodological determination of their taxonomic affiliation is substantiated.
    Type of Medium: Online Resource
    ISSN: 2412-0650 , 0016-9900
    URL: Issue
    URL: Article
    DOI: 10.47470/0016-9900-2022-101-8
    DOI: 10.47470/0016-9900-2022-101-8-896-903
    Language: Unknown
    Publisher: Federal Scientific Center for Hygiene F.F.Erisman
    Publication Date: 2022
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  • 7
    Online Resource
    Online Resource
    BRONZE AGE SHEPHERDS AND METALLURGISTS: ISOTOPE DATA AND RECONSTRUCTION OF SEASONAL MIGRATIONS
    Institute of History and Archaeology of Ural Branch of Russian Academy of Science ; 2020
    In:  Ural Historical Journal Vol. 69, No. 4 ( 2020), p. 15-23
    Details
    In: Ural Historical Journal, Institute of History and Archaeology of Ural Branch of Russian Academy of Science, Vol. 69, No. 4 ( 2020), p. 15-23
    Abstract: The aim of the paper is to analyze animal bone assemblages from seasonal Catacomb culture campsites of the Salsk-Manych Ridge and from the Mikhailo-Ovsyanka Srubnaya settlement located in the steppe Trance-Volga region. Proposed models of seasonal population movements are based on the animal bone assemblage, the slaughter age of animals, seasonality of the animal slaughter, animal ratio and identification of local/non-local animals. The Catacomb population developed an economic system based on the rotation of seasonal pastures and organized seasonal movements within the developed economic areas. Isotope data confirm the seasonal character of the explored sites. The local Srubnaya population searched and mined ore, smelted metal, and cast items on a seasonal basis: from mid-summer to autumn. It was not possible to extract ore during the winter. The slaughter age analysis indicates to a seasonal and/or free-range system of animal husbandry. Stable isotope data demonstrates that animals were grazing near the site or in nearby areas. The local groups primarily exploited the resources in the Irgiz river basin. The presence of non-local animals could have been a result of exchange system with population from areas located far away from the place where the metal was produced.
    Type of Medium: Online Resource
    ISSN: 1728-9718
    Uniform Title: ПАСТУХИ И МЕТАЛЛУРГИ БРОНЗОВОГО ВЕКА: АНАЛИЗ ИЗОТОПНЫХ ДАННЫХ И РЕКОНСТРУКЦИЯ СЕЗОННЫХ ПЕРЕМЕЩЕНИЙ
    URL: Issue
    URL: Article
    DOI: 10.30759/1728-9718-2020-4(69)
    DOI: 10.30759/1728-9718-2020-4(69)-15-23
    Language: Unknown
    Publisher: Institute of History and Archaeology of Ural Branch of Russian Academy of Science
    Publication Date: 2020
    detail.hit.zdb_id: 2864244-2
    SSG: 7,41
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  • 8
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    Online Resource
    WATER-SOLUBLE POLYMERIC IONIC 5-FLUOROURACIL COMPLEX BASED ON METHACRYLIC ACID COPOLYMERS
    Innovare Academic Sciences Pvt Ltd ; 2019
    In:  International Journal of Applied Pharmaceutics ( 2019-05-10), p. 214-219
    Details
    In: International Journal of Applied Pharmaceutics, Innovare Academic Sciences Pvt Ltd, ( 2019-05-10), p. 214-219
    Abstract: Objective: The objective of this work was to obtain a water-soluble 5-fluorouracil (5-FU) polymeric complex on the basis of a methacrylic acid (MAA) copolymer to be used as an injectable chemotherapeutic agent. Methods: A polymeric carrier was synthesized using tert-butyl methacrylate (TBMA) as a monomer, thioglycolic acid, and azobisisobutyronitrile as a radical polymerization initiator. The polymer was converted by acid hydrolysis into a water-soluble copolymer of TBMA and MAA of 20: 80 mass%, respectively. The copolymer of TBMA and MAA was modified with 5-FU. Their formation was proved using IR and UV spectroscopy. The particle size of the 5-FU polymeric complex was estimated by turbidimetry, which is based on measuring the intensity of light transmitted through a disperse system. The release of 5-FU from the obtained ionic complexes by dialysis in vitro was evaluated. Results: Polymeric carriers were obtained with different amounts of 5-FU (5, 15, 25, 50 mol%). A high peak at λ = 266 nm was observed in the UV spectrum of the polymeric carrier (characteristic of 5-FU). The particle size was estimated at 13 nm for the complex with 5 mol% 5-FU and 26.8 n for the complex with 50 mol% 5-FU. The 5-FU release was estimated in two parallel experiments at 37 °C. One utilized a phosphate-citrate buffer with pH 5.0 to model the intracellular space and the other, a phosphate buffer with pH 7.4 to model the intravascular space. Two systems, with 5 and 15 mol% 5-FU, were chosen for testing. In both phosphate buffer and phosphate-citrate buffer, 5-FU was released from the polymeric complex with 5 mol% 5-FU approximately 1.3 times faster than from the complex containing 5 mol% 5-fluorouracil. The kinetics of 5-FU release from the polymeric complex (5 mol% 5-fluorouracil) showed that the 5-FU release was 77.9% in phosphate-citrate buffer and 59.6% in phosphate buffer over 52 h of dialysis. When the 5-FU release kinetics was studied with the polymeric complex containing 15 mol% 5-FU, the 5-FU release was 100.0% in phosphate-citrate buffer and 75.1% in phosphate buffer over 57 h of dialysis. Conclusion: Water-soluble nanoscale complexes of 5-FU with TBMA–MAA copolymers extend application of 5-FU, while its general toxicity might be lower. The complexes are sufficiently stable at pH 7.4 and readily release 5-FU at pH 5.0.
    Type of Medium: Online Resource
    ISSN: 0975-7058
    URL: Article
    DOI: 10.22159/ijap.2019v11i4.32919
    Language: Unknown
    Publisher: Innovare Academic Sciences Pvt Ltd
    Publication Date: 2019
    detail.hit.zdb_id: 2675577-4
    SSG: 15,3
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  • 9
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    Online Resource
    Methylation of the BIN1 gene promoter CpG island associated with breast and prostate cancer
    Medknow ; 2007
    In:  Journal of Carcinogenesis Vol. 6, No. 1 ( 2007), p. 9-
    Details
    In: Journal of Carcinogenesis, Medknow, Vol. 6, No. 1 ( 2007), p. 9-
    Type of Medium: Online Resource
    ISSN: 1477-3163
    URL: Article
    DOI: 10.1186/1477-3163-6-9
    Language: Unknown
    Publisher: Medknow
    Publication Date: 2007
    detail.hit.zdb_id: 2098237-9
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  • 10
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    Online Resource
    Exploring the impact of homework assignments on achievement and attitudes in science education
    Modestum Ltd ; 2023
    In:  Eurasia Journal of Mathematics, Science and Technology Education Vol. 19, No. 4 ( 2023-04-01), p. em2246-
    Details
    In: Eurasia Journal of Mathematics, Science and Technology Education, Modestum Ltd, Vol. 19, No. 4 ( 2023-04-01), p. em2246-
    Abstract: The aim of this study is to review the effects of homework in science education studies in the electronic database. Moreover, journals published in the electronic database were searched using the same keyword. 21 studies were chosen related to the effects of homework in the science education context and analyzed by means of standards obtained from the related literature. A qualitative thematic review was used in this study. All articles were downloaded and read by the researchers. Each researcher studied together to determine themes. The themes were decided as students’, teachers’, and parents’ views about homework assignments and the positive and negative effects of homework assignments on achievement, and attitudes. Results were reviewed in terms of the effects of a homework assignment in science education studies. Some implications of these results were proposed for determining and developing the effects of homework assignments in science education studies.
    Type of Medium: Online Resource
    ISSN: 1305-8215 , 1305-8223
    URL: Article
    DOI: 10.29333/ejmste/13058
    Language: Unknown
    Publisher: Modestum Ltd
    Publication Date: 2023
    detail.hit.zdb_id: 2191612-3
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