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  • 1
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2016
    In:  IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing Vol. 9, No. 9 ( 2016-9), p. 3941-3956
    In: IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing, Institute of Electrical and Electronics Engineers (IEEE), Vol. 9, No. 9 ( 2016-9), p. 3941-3956
    Type of Medium: Online Resource
    ISSN: 1939-1404 , 2151-1535
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016
    detail.hit.zdb_id: 2457423-5
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  • 2
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2010
    In:  IEEE Transactions on Industry Applications Vol. 46, No. 5 ( 2010-09), p. 1755-1763
    In: IEEE Transactions on Industry Applications, Institute of Electrical and Electronics Engineers (IEEE), Vol. 46, No. 5 ( 2010-09), p. 1755-1763
    Type of Medium: Online Resource
    ISSN: 0093-9994
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2010
    detail.hit.zdb_id: 2027530-4
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  • 3
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Psychiatry Vol. 12 ( 2021-6-29)
    In: Frontiers in Psychiatry, Frontiers Media SA, Vol. 12 ( 2021-6-29)
    Abstract: Objectives: The identification of clinically relevant subtypes of insomnia is important. Including a comprehensive literature review, this study also introduces new phenotypical relevant parameters by describing a specific insomnia cohort. Methods: Patients visiting the sleep center and indicating self-reported signs of insomnia were examined by a sleep specialist who confirmed an insomnia diagnosis. A 14-item insomnia questionnaire on symptoms, progression, sleep history and treatment, was part of the clinical routine. Results: A cohort of 456 insomnia patients was described (56% women, mean age 52 ± 16 years). They had suffered from symptoms for about 12 ± 11 years before seeing a sleep specialist. About 40–50% mentioned a trigger (most frequently psychological triggers), a history of being bad sleepers to begin with, a family history of sleep problems, and a negative progression of insomnia. Over one third were not able to fall asleep during the day. SMI (sleep maintenance insomnia) symptoms were most frequent, but only prevalence of EMA (early morning awakening) symptoms significantly increased from 40 to 45% over time. Alternative non-medical treatments were effective in fewer than 10% of cases. Conclusion: Our specific cohort displayed a long history of suffering and the sleep specialist is usually not the first point of contact. We aimed to describe specific characteristics of insomnia with a simple questionnaire, containing questions (e.g., ability to fall asleep during the day, effects of non-medical therapy methods, symptom stability) not yet commonly asked and of unknown clinical relevance as yet. We suggest adding them to anamnesis to help differentiate the severity of insomnia and initiate further research, leading to a better understanding of the severity of insomnia and individualized therapy. This study is part of a specific Research Topic introduced by Frontiers on the heterogeneity of insomnia and its comorbidity and will hopefully inspire more research in this area.
    Type of Medium: Online Resource
    ISSN: 1664-0640
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2564218-2
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  • 4
    In: Frontiers in Cellular and Infection Microbiology, Frontiers Media SA, Vol. 12 ( 2022-5-16)
    Abstract: The human gut acts as the main reservoir of microbes and a relevant source of life-threatening infections, especially in immunocompromised patients. There, the opportunistic fungal pathogen Candida albicans adapts to the host environment and additionally interacts with residing bacteria. We investigated fungal-bacterial interactions by coinfecting enterocytes with the yeast Candida albicans and the Gram-negative bacterium Proteus mirabilis resulting in enhanced host cell damage. This synergistic effect was conserved across different P. mirabilis isolates and occurred also with non- albicans Candida species and C. albicans mutants defective in filamentation or candidalysin production. Using bacterial deletion mutants, we identified the P. mirabilis hemolysin HpmA to be the key effector for host cell destruction. Spatially separated coinfections demonstrated that synergism between Candida and Proteus is induced by contact, but also by soluble factors. Specifically, we identified Candida -mediated glucose consumption and farnesol production as potential triggers for Proteus virulence. In summary, our study demonstrates that coinfection of enterocytes with C. albicans and P. mirabilis can result in increased host cell damage which is mediated by bacterial virulence factors as a result of fungal niche modification via nutrient consumption and production of soluble factors. This supports the notion that certain fungal-bacterial combinations have the potential to result in enhanced virulence in niches such as the gut and might therefore promote translocation and dissemination.
    Type of Medium: Online Resource
    ISSN: 2235-2988
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2619676-1
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  • 5
    Online Resource
    Online Resource
    Klett-Cotta Journals ; 2021
    In:  Ärztliche Psychotherapie Vol. 16, No. 3 ( 2021-08), p. 130-131
    In: Ärztliche Psychotherapie, Klett-Cotta Journals, Vol. 16, No. 3 ( 2021-08), p. 130-131
    Type of Medium: Online Resource
    ISSN: 1862-4715
    Language: Unknown
    Publisher: Klett-Cotta Journals
    Publication Date: 2021
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  • 6
    Online Resource
    Online Resource
    Royal Society of Chemistry (RSC) ; 1997
    In:  Chemical Communications , No. 13 ( 1997), p. 1207-1208
    In: Chemical Communications, Royal Society of Chemistry (RSC), , No. 13 ( 1997), p. 1207-1208
    Type of Medium: Online Resource
    ISSN: 1359-7345 , 1364-548X
    Language: Unknown
    Publisher: Royal Society of Chemistry (RSC)
    Publication Date: 1997
    detail.hit.zdb_id: 1472881-3
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  • 7
    Online Resource
    Online Resource
    Frontiers Media SA ; 2023
    In:  Frontiers in Rehabilitation Sciences Vol. 3 ( 2023-1-23)
    In: Frontiers in Rehabilitation Sciences, Frontiers Media SA, Vol. 3 ( 2023-1-23)
    Abstract: COVID-19 is associated with various symptoms and psychological involvement in the long term. In view of the multifactorial triggering and maintenance of the post-COVID syndrome, a multimodal therapy with somatomedical and psychotherapeutic content is expedient. This paper compares the psychological stress of post-COVID patients and their course in rehabilitation to psychosomatic and psychocardiological patients. Method Observational study with control-groups and clinical, standardized examination: psychological testing (BDI-II, HELATH-49), 6-MWT as somatic parameter, two measurement points (admission, discharge). Sample characteristics, including work related parameters, the general symptom-load and the course of symptoms during rehabilitation are evaluated. Results At admission in all measures post-COVID patients were significantly affected, but less pronounced than psychosomatic or psychocardiological patients (BDI-II post-COVID = 19.29 ± 9.03, BDI-II psychosomatic = 28.93 ± 12.66, BDI-II psychocardiology = 24.47 ± 10.02). During rehabilitation, in all complaint domains and sub-groups, symptom severity was significantly reduced (effect sizes ranging from d  = .34 to d  = 1.22). Medium positive effects were seen on self-efficacy ( d  = .69) and large effects on activity and participation ( d  = 1.06) in post-COVID patients. In the 6-MWT, the walking distance improved by an average of 76.43 ± 63.58 meters ( d  = 1.22). Not a single patient deteriorated in walking distance, which would have been a possible sign of post exercise malaise (PEM). Conclusion Post-COVID patients have a slighter psychological burden as psychocardiological or psychosomatic patients. Although rehabilitation is not curative, post-COVID patients benefit significantly from the interventions and there were no signs of PEM.
    Type of Medium: Online Resource
    ISSN: 2673-6861
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 3091712-8
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