In:
African Journal of Traditional, Complementary and Alternative Medicines, African Traditional Herbal Medicine Supporters Initiative (ATHMSI), Vol. 14, No. 5 ( 2017-10-01), p. 113-120
Abstract:
Background: Ischemia-induced brain damage is the leading cause of adult disability and the fifth leading cause of death, and thus, the development of anti-apoptotic neuro-protective therapeutic agents is viewed as an attractive developmental strategy. Glycyrrhizin is the main sweet component in licorice and has a number of pharmacological activities, which include neuro-protective, anti-fungal, and anti-cariogenic activities. This study was undertaken to investigate the effects of glycyrrhizin on ischemia-induced brain damage. Materials and Methods: In infarct volumes and the levels of several apoptosis-related proteins, caspase-3, - 8, 9, Bcl-xL, Bcl-2,and their activities in the brains of middle cerebral artery occlusion (MCAO) treated mice were measured using western blotting methods. Results: Single pre-treatment with glycyrrhizin (10-100 mg/kg)at 2 hours before MCAO significantly reduced infarct volumes at 24h after MCAO. In addition, glycyrrhizin effectively inhibited the activations of caspase-3 and -9 and the down-regulation of Bcl-xLprotein caused by MCAO. Conclusion: The neuro-protective effect of glycyrrhizin was found to be due to its regulation of apoptosisrelated proteins signals.The authors suggest glycyrrhizin be considered a potential candidate for the treatment of ischemia induced brain damage.
Type of Medium:
Online Resource
ISSN:
2505-0044
,
0189-6016
DOI:
10.21010/ajtcam.v14i5.15
Language:
Unknown
Publisher:
African Traditional Herbal Medicine Supporters Initiative (ATHMSI)
Publication Date:
2017
detail.hit.zdb_id:
2193092-2
Permalink