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    Online Resource
    Online Resource
    EDITORA SCIENTIFIC ; 2003
    In:  Revista Brasileira de Psiquiatria Vol. 25, No. 2 ( 2003-06), p. 103-109
    In: Revista Brasileira de Psiquiatria, EDITORA SCIENTIFIC, Vol. 25, No. 2 ( 2003-06), p. 103-109
    Abstract: Esse artigo realiza uma revisão da história e do quadro clínico da síndrome de Asperger, considerando orientações para a avaliação clínica e o tratamento. Aspectos da validade dessa entidade nosográfica, as limitações das pesquisas atuais e as potenciais vantagens dessa linha de investigação são revisadas. Conclui discutindo a necessidade da implementação de serviços educacionais e o estabelecimento de outras intervenções de maneira adequada para o atendimento de indivíduos com graves alterações da sociabilidade, independentemente da validade e utilidade desse diagnóstico.
    Type of Medium: Online Resource
    ISSN: 1516-4446
    Language: Unknown
    Publisher: EDITORA SCIENTIFIC
    Publication Date: 2003
    detail.hit.zdb_id: 2024119-7
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  • 2
    Online Resource
    Online Resource
    EDITORA SCIENTIFIC ; 2006
    In:  Revista Brasileira de Psiquiatria Vol. 28, No. suppl 1 ( 2006-05), p. s1-s2
    In: Revista Brasileira de Psiquiatria, EDITORA SCIENTIFIC, Vol. 28, No. suppl 1 ( 2006-05), p. s1-s2
    Type of Medium: Online Resource
    ISSN: 1516-4446
    Language: Unknown
    Publisher: EDITORA SCIENTIFIC
    Publication Date: 2006
    detail.hit.zdb_id: 2024119-7
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  • 3
    Online Resource
    Online Resource
    EDITORA SCIENTIFIC ; 2006
    In:  Revista Brasileira de Psiquiatria Vol. 28, No. suppl 1 ( 2006-05), p. s3-s11
    In: Revista Brasileira de Psiquiatria, EDITORA SCIENTIFIC, Vol. 28, No. suppl 1 ( 2006-05), p. s3-s11
    Abstract: Autism and Asperger syndrome are diagnostic entities in a family of neurodevelopmental disorders disrupting fundamental processes of socialization, communication and learning, collectively known as pervasive developmental disorders. This group of conditions is among the most common developmental disorders, affecting 1 in every 200 or so individuals. They are also the most strongly genetically related among developmental disorders, with recurrence risks within sibships of the order of 2 to 15% if a broader definition of affectedness is adopted. Their early onset, symptom profile, and chronicity implicate fundamental biological mechanisms involved in social adaptation. Advances in their understanding are leading to a new social neuroscience perspective of normative socialization processes and specific disruptions thereof. These processes may lead to the emergence of the highly heterogeneous phenotypes associated with autism, the paradigmatic pervasive developmental disorder, and its variants. This overview focuses on the history, nosology, and the clinical and associated features of the two most well-known pervasive developmental disorders - autism and Asperger syndrome.
    Type of Medium: Online Resource
    ISSN: 1516-4446
    Language: Unknown
    Publisher: EDITORA SCIENTIFIC
    Publication Date: 2006
    detail.hit.zdb_id: 2024119-7
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  • 4
    Online Resource
    Online Resource
    Lifescience Global ; 2015
    In:  International Journal of Statistics in Medical Research Vol. 4, No. 2 ( 2015-05-21), p. 180-187
    In: International Journal of Statistics in Medical Research, Lifescience Global, Vol. 4, No. 2 ( 2015-05-21), p. 180-187
    Abstract: Autism spectrum disorder (autism) is a common and heterogeneous neurodevelopmental disorder of genetic origins defined by challenges in social communication and clusters of restrictive and repetitive behaviors. An emerging hypothesis of autism pathogenesis describes symptoms as the results from deviations from normative developmental processes. In this account, symptoms represent the outcome of variable instantiation of genetic liabilities – in terms of dosage and timing – leading to disruptions in the developmental trajectories of foundational social adaptive skills. Given the fast pace of change in behavior and brain development in the first two years of life, we pose that the currently prevalent cross-sectional experimental designs are ill-suited to capture changes from normative benchmarks that might be small at any data point but which inexorably and cumulatively increase divergences in developmental trajectories that ultimately culminate in the unmistakable cluster of atypical behaviors we now call autism. We argue that only densely-sampled longitudinal experimental designs can capture the underlying dynamic processes moving the individual child’s development towards or away from normative benchmarks. We illustrate this phenomenon via a detailed example in which a cross-sectional comparison between a clinical and a control cohort failed to find differences, which could only be detected by ascertaining that the developmental trajectory of one cohort was moving upwards while the other was moving downwards, with the developmental lines intersecting at the cross-sectional data point. We conclude by magnifying Karmiloff-Smith’s assertion, oft-quoted but seldom followed, that “development itself is the key to understanding developmental disorders” [1] .
    Type of Medium: Online Resource
    ISSN: 1929-6029
    Language: Unknown
    Publisher: Lifescience Global
    Publication Date: 2015
    detail.hit.zdb_id: 2810580-1
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