In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 93, No. 3 ( 1980-03), p. 315-321
Abstract:
In order to compare the acute effects of three methods of treatment in hyperthyroid patients with diffuse goitre, values of thyroxine (T 4 ), triiodothyronine (T 3 ) in serum, T 3 -resin uptake (T 3 -U), free thyroxine index (FT 4 I) and free triiodothyronine index (FT 3 I) were employed as thyroid function parameters. In iodide (I − ) group given iodine (3 or 6 mg/day) as iodinated lecithine once daily, the parameters were reduced acutely within one week after the start of treatment, reaching a plateau during the next week. In contrast to the changes in I − group, the thyroid function was decreased gradually and consistently for two weeks in the propylthiouracil (PTU 300 mg/day) group. In PTU + I − (300 mg/PTU plus 3 or 6 mg/iodide/day) group, the parameters were reduced acutely and progressively for two weeks. These results indicate that PTU +I − therapy is much more effective than PTU or I − alone in early phase treatment of hyperthyroidism. Another new finding was that the thyroid function increased again during the later addition of PTU (300 mg/day) in the patients treated with I − (3 or 6 mg/day) for one or two weeks. The well-known escape phenomenon from iodide inhibition took place counteracted the effect of PTU. Since blocking of thyroidal secretion by I − is only transient while synthesis of T 3 and T 4 continues, leading to greater amount of hormone stored in the gland, the treatment of hyperthyroidism with I − alone is a risky procedure.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.0930315
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1980
detail.hit.zdb_id:
1485160-X
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