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  • 1
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2024
    In:  IEEE Transactions on Biomedical Engineering Vol. 71, No. 7 ( 2024-7), p. 2265-2275
    In: IEEE Transactions on Biomedical Engineering, Institute of Electrical and Electronics Engineers (IEEE), Vol. 71, No. 7 ( 2024-7), p. 2265-2275
    Type of Medium: Online Resource
    ISSN: 0018-9294 , 1558-2531
    RVK:
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2024
    detail.hit.zdb_id: 2021742-0
    detail.hit.zdb_id: 2571926-9
    detail.hit.zdb_id: 2561637-7
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  • 2
    In: Frontiers in Public Health, Frontiers Media SA, Vol. 10 ( 2022-8-10)
    Abstract: Linezolid is an oxazolidinone antibacterial drug, and its therapeutic drug monitoring and individualized treatment have been challenged since its approval. With the in-depth clinical research of linezolid, we have changed our attitude toward its therapeutic drug monitoring and our view of individualized treatment. On the basis of summarizing the existing clinical studies, and based on the practical experience of each expert in their respective professional fields, we have formed this expert consensus. Our team of specialists is a multidisciplinary team that includes pharmacotherapists, clinical pharmacology specialists, critical care medicine specialists, respiratory specialists, infectious disease specialists, emergency medicine specialists and more. We are committed to the safe and effective use of linezolid in patients in need, and the promotion of its therapeutic drug monitoring.
    Type of Medium: Online Resource
    ISSN: 2296-2565
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2711781-9
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  • 3
    Online Resource
    Online Resource
    NADIA ; 2017
    In:  International Journal of Signal Processing, Image Processing and Pattern Recognition Vol. 10, No. 1 ( 2017-01-31), p. 191-204
    In: International Journal of Signal Processing, Image Processing and Pattern Recognition, NADIA, Vol. 10, No. 1 ( 2017-01-31), p. 191-204
    Type of Medium: Online Resource
    ISSN: 2005-4254 , 2005-4254
    URL: Issue
    Language: Unknown
    Publisher: NADIA
    Publication Date: 2017
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  • 4
    Online Resource
    Online Resource
    Innovation Publishing House Pte. Ltd. ; 2022
    In:  STEMedicine Vol. 3, No. 4 ( 2022-09-04), p. e145-
    In: STEMedicine, Innovation Publishing House Pte. Ltd., Vol. 3, No. 4 ( 2022-09-04), p. e145-
    Abstract: Background: Nursing home is critical for the elderly. Methods: To investigate the effects of decision-making process in terms of choosing room type and roommates on cognitive and psychosocial conditions of the elderly, 174 eligible participants were randomly assigned into three groups. In the first two groups, participants were randomly assigned to single-person rooms (Group SPR, n = 58) and multi-person rooms (2–4 persons per room, Group MPR, n = 58), and the third group of participants were allowed to voluntarily choose to live in single-person room or with preferred roommates (Group VPR, n = 58). Results: Participants who voluntarily choose room type and roommates (Group VPR) showed the least deterioration of cognitive function, psychosocial, and physical health, with Group MPR showing less deterioration than Group SPR. Allowing elderly people to voluntarily choose room type and roommate is better for preserving their cognitive, psychological, and physical health. Conclusions: Voluntary choice of room type and roommates is beneficial to the cognitive, psychological, and physical health of elderly people.
    Type of Medium: Online Resource
    ISSN: 2705-1188
    Language: Unknown
    Publisher: Innovation Publishing House Pte. Ltd.
    Publication Date: 2022
    detail.hit.zdb_id: 3035232-0
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  • 5
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 11 ( 2023-5-11)
    Abstract: Based on porosity and permeability tests, high-pressure mercury injection (HPMI), nuclear magnetic resonance (NMR) and centrifugal experiments, this study comprehensively analyzed the quality, pore structure and fractal characteristics of tight sandstone reservoir in meandering stream facies. The purpose is to reveal the relationship between physical properties, geometry and topological parameters of pores, fluid mobility and heterogeneity of pore system of tight sandstone reservoirs in meandering stream facies. The results show that the second member of the Middle Jurassic Shaximiao Formation (J 2 S 2 ) in the central Sichuan Basin has developed tight sandstone reservoir of meandering fluvial facies, the pore radius of type I reservoir (K & gt;0.3 mD) is mainly distributed at 0.01 μm∼2 μm, the tortuosity ranges between 2.571 and 2.869, and the average movable fluid saturation is 70.12%. The pore radius of type II reservoir (0.08mD & lt;K & lt;0.3 mD) is mainly 0.003 μm∼1 μm, the tortuosity ranges between 2.401 and 3.224, the average movable fluid saturation is 57.59%. The pore radius of type III reservoir (K & lt;0.08 mD) is mainly 0.001 μm∼0.4 μm, the tortuosity ranges between 0.905 and 2.195, and the average movable fluid saturation is 13.46%. Capillary-Paraachor point (CP point) and T2 cut-off value (T 2cutoff ) are used to divide the fractal interval of capillary pressure curve and T 2 spectrum. The fractal dimension D h2 of small pores calculated by HPMI through 3D capillary tube model, the fractal dimension D n1 of large pores and D n2 of small pores calculated by NMR through wetting phase model can effectively characterize the heterogeneity of reservoir pores. Among them, D n1 has a strong negative correlation with porosity, permeability, pore radius and movable fluid saturation, indicating that the reservoir capacity, seepage capacity and pore size are mainly controlled by large pores, therefore, D n1 can be used as an effective reservoir evaluation parameter.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2741235-0
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  • 6
    Online Resource
    Online Resource
    Frontiers Media SA ; 2021
    In:  Frontiers in Oncology Vol. 11 ( 2021-5-13)
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 11 ( 2021-5-13)
    Abstract: LncRNAs play important roles in bladder cancer. However, only a few studies report on the correlation between lncRNAs expression and autophagy in bladder cancer. This study aimed to explore the effect of lncRNA on autophagy in bladder cancer. The findings showed high expression of SNHG1 in the bladder cancer cells and tumor tissues. The high expression of SNHG1 was positively correlated with bladder cancer cell invasion, proliferation, and autophagy. This finding implies that SNHG1 promotes bladder cancer cell invasion and proliferation via autophagy. Further analysis of the mechanism of action of SNHG1 showed that it functions as a sponge of miRNA-493 in bladder cancer. miRNA-493 binds on the 3’ -UTR of ATG14 mRNA thus affecting ATG14 protein expression, which is implicated in autophagy. These findings are supported by previous preclinical studies using multiple Bca cell lines and TCGA, which demonstrate that SNHG1 plays an oncogenic role by acting as a sponge of miR-493-5p or as its ceRNA. Upregulation of SNHG1 promotes proliferation, invasion, and autophagy of bladder cancer cells through the miR-493-5p/ATG14/autophagy pathway. Therefore, SNHG1 may act as a potential therapeutic target for the treatment of bladder cancer.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2649216-7
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  • 7
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-6-8)
    Abstract: Inflammatory cytokines including TNF-α and IL-1β impair intestinal barrier function in aging by disrupting intestinal tight junction integrity. Icariin (ICA) has a variety of pharmacological effects. Indeed, ICA produces anti-inflammatory, anti-oxidative stress, and inhibitory effects on microRNA (miRNA) expression. This study was to explore whether ICA could alleviate inflammation-associated intestinal barrier function impairment in aging and its underlying mechanism. Of particular interest, network pharmacology prediction indicated the potential therapeutic impacts of ICA for the treatment of colitis. Then, rats were used to study whether ICA has a protective effect on the reduction of tight junctions caused by inflammatory cytokines. Next, Caco-2 cell monolayers were used to explore the mechanism by which ICA alleviates the down-regulation of tight junctions. Network pharmacology prediction revealed that ICA alleviated colitis via suppressing oxidative stress. After ICA intervention, expressions of inflammatory cytokines were reduced, but tight junctions, antioxidant enzymes in aging rats were up-regulated. ICA reversed the TNF-α-induced decrease in abundance of Occludin protein in Caco-2 cell monolayers. Meanwhile, ICA alleviated the increase in permeability and expression of miR-122a. However, the protective effect of ICA was markedly attenuated after transfection with miR-122a mimics. In conclusion, ICA reduced the expressions of Occludin, Claudin1, and Claudin5 in colon, which were related to the reduction of TNF-α and IL-1β and alleviation of colonic in vivore . And ICA attenuated TNF-α-induced Occludin disruption and epithelial barrier impairment by decreasing miR-122a expression in Caco-2 cell monolayers.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 8
    In: Experimental and Therapeutic Medicine, Spandidos Publications, Vol. 21, No. 4 ( 2021-02-05)
    Type of Medium: Online Resource
    ISSN: 1792-0981 , 1792-1015
    Language: Unknown
    Publisher: Spandidos Publications
    Publication Date: 2021
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  • 9
    Online Resource
    Online Resource
    The Electrochemical Society ; 2022
    In:  ECS Meeting Abstracts Vol. MA2022-01, No. 29 ( 2022-07-07), p. 1270-1270
    In: ECS Meeting Abstracts, The Electrochemical Society, Vol. MA2022-01, No. 29 ( 2022-07-07), p. 1270-1270
    Abstract: ABSTRACT Advanced Process Control (APC) has been widely applied in state-of-the-art semiconductor industries for the everlasting pursuit of cycle time reduction, higher yield and zero scrap. Inline metrology is thus valuable input feeds for the improvement of wafer-to-wafer and within-wafer CD variations originated from either abnormality or noise of different processes. Implementing a suitable APC scheme to process flow remains a challenging task for engineers. In most cases, it is enough to implement the APC to only one single pattern on Chip. However, for multi-purpose chip design, the CD control of multiple patterns is becoming important. In this paper, we presented a workflow of APC to control the CD of two different patterns. It is shown that, with the same amount of APC process layers, we were able to improve from single pattern CD control to dual pattern CD control. The final process variations of two patterns can be controlled within ±0.5 nm. INTRODUCTION Abnormality and noise are two inevitable root causes of systematic yield loss and mis-process during semiconductor manufacturing processes [1]. Within-wafer uniformity is another important indication of process control capability. Lam tools implement Hydra Electro Static Chuck (ESC) combining the 4 radially-tunable zones with grid-heating elements, where additional CDU tuning is made possible for radial and non-radial uniformity [2] . APC schemes are normally applied to a single pattern as the anchor point to control the CD and CDU. However, for multi-purpose chip layouts, areas of different CDs and pitches are designed. For instance, CD controlling of both Logic and SRAM are important for yield improvement and device performance. When APC is implemented to different processes across the production flow, it is possible to utilize properly the inline metrology data of different patterns across processes for a dual pattern control. For this purpose, The APC CD control scheme of dual patterns is demonstrated in this work. SETUP The process flow is divided into 4 stages. In stage 1, a hard mask (HM) is patterned with a Lithograph-Etching (LE) process. An added CD trimming process of stage 2 is added to cover the LE etch bias (EB) incapability. Pattern B is covered by photoresist materials to trim the CD of pattern A HM to the target value. In stage 3, a thin Atomic Layer Deposition (ALD) layer is deposited on the HM of both patterns A and B for etching protection. In stage 4, the final etch process is completed with the HMs of target CDs. RESULTS and DISCUSSIONS For single pattern APC, pattern A is designated as the anchor pattern for this scheme. For stage 1, the Hydra function is applied to pattern A to improve its CDU. Here we assume that the Hydra function barely improves the CD or CDU of pattern B, due to the fact that pattern A and pattern B have different line CDs and Pitches. In stage 2, APC is turned on using inline data of pattern A from stage 1. Pattern A is exposed for the isotropic plasma dry etching process until target CD is reached. Pattern B is covered in photoresist materials, and its CD is not changed during this process. And the photoresist materials are removed afterward. In stage 3. Fixed-amount ALD process is applied for HM protection on both Pattern A and B. In stage 4, HM is used to etch the pattern into substrate Si with Hydra function turned on for pattern A only. During this process flow, CD and CDU APC are applied to pattern A only. The process variation of stage 1 on pattern B is transferred all the way down to the final stage 4 without any APC functioning on Pattern B. Figure 1 shows the new APC flow. In stage 1, HM of pattern A and pattern B are etched with Hydra function working on pattern A only. However, inline metrology is applied to pattern B for APC of stage 3. In stage 2, Pattern A trimming changed from APC-mode to fixed time mode. The APC function is turned on for stage 3 for a global CD control of both pattern A and pattern B using ALD. And Hydra function is turned on for stage 4 for a CDU control on pattern A. It is shown that the CD variation originated from stage 1 is compensated on stage 3. With the same amount of APC stages, the effect of the APC can be improved from pattern A CD/CDU only, to pattern A CD/CDU and pattern B CD control. Figure 1
    Type of Medium: Online Resource
    ISSN: 2151-2043
    Language: Unknown
    Publisher: The Electrochemical Society
    Publication Date: 2022
    detail.hit.zdb_id: 2438749-6
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  • 10
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 15 ( 2024-5-10)
    Abstract: The increasing incidence and mortality of prostate cancer worldwide significantly impact the life span of male patients, emphasizing the urgency of understanding its pathogenic mechanism and associated molecular changes that regulate tumor progression for effective prevention and treatment. RNA modification, an important post-transcriptional regulatory process, profoundly influences tumor cell growth and metabolism, shaping cell fate. Over 170 RNA modification methods are known, with prominent research focusing on N6-methyladenosine, N7-methylguanosine, N1-methyladenosine, 5-methylcytidine, pseudouridine, and N4-acetylcytidine modifications. These alterations intricately regulate coding and non-coding RNA post-transcriptionally, affecting the stability of RNA and protein expression levels. This article delves into the latest advancements and challenges associated with various RNA modifications in prostate cancer tumor cells, tumor microenvironment, and core signaling molecule androgen receptors. It aims to provide new research targets and avenues for molecular diagnosis, treatment strategies, and improvement of the prognosis in prostate cancer.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 2606823-0
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