In:
European Journal of Endocrinology, Oxford University Press (OUP), Vol. 175, No. 6 ( 2016-12), p. 571-582
Abstract:
Non-pharmacological interventions are important in reducing risk for osteoporotic fractures. We investigated the effects of a 16-week individualized resistance training intervention on bone mineral density (BMD), bone turnover markers and 10-year relative risk (RR) for osteoporotic fracture. Design Interventional study with a follow-up. Methods In total, 37 elderly women (mean age 71.9 ± 3.1 years) with decreased muscle strength participated in the resistance training intervention three times per week with 60 min per session for 16 weeks under the supervision of a licensed physiotherapist. Total hip BMD with quantitative CT, bone markers (sclerostin, osteocalcin, CTX, PINP, IGF-1, 25(OH)-D) and 10-year RR for osteoporotic fracture were measured at baseline, post-intervention and at 1-year follow-up after the end of the intervention. Eleven age- and sex-matched controls did not participate in the intervention but were studied at baseline and at 1-year follow-up. Results Resistance training seemed to increase total hip BMD by 6% ( P = 0.005). Sclerostin ( P 〈 0.001) and total osteocalcin ( P = 0.04) increased while other bone markers remained unchanged. A 10-year RR for major osteoporotic and hip fracture remained unchanged. At follow-up total hip BMD ( P 〈 0.001) decreased back to the baseline level with a simultaneous decrease in serum sclerostin ( P = 0.045), CTX ( P 〈 0.001) and an increase in 25(OH)-D ( P 〈 0.001), 10-year RR for major osteoporotic ( P = 0.002) and hip fracture ( P = 0.01). Conclusions Our findings suggest an important role of continuous supervised resistance training for the prevention of osteoporotic fractures in elderly women with decreased muscle strength.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
2016
detail.hit.zdb_id:
1485160-X
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