In:
Transplant International, Frontiers Media SA, Vol. 35 ( 2022-5-30)
Abstract:
The impact of pretransplant and posttransplant alcohol consumption on outcomes in kidney transplant recipients (KTRs) is uncertain. Self-reported alcohol consumption was obtained at the time of transplant and 2 years after transplant in a prospective cohort study. Among 907 KTRs, 368 (40.6%) were drinkers at the time of transplant. Compared to non-drinkers, alcohol consumption did not affect the risk of death-censored graft failure (DCGF), biopsy-proven acute rejection (BPAR), cardiovascular events, or all-cause mortality. Compared to persistent non-drinkers, the development of DCGF, BPAR, cardiovascular events, all-cause mortality, or posttransplant diabetes mellitus was not affected by the alcohol consumption pattern (persistent, de novo , or stopped drinking) over time. However, de novo drinkers had a significantly higher total cholesterol ( p & lt; 0.001) and low-density lipoprotein cholesterol levels ( p = 0.005) compared to persistent non-drinkers 5 years after transplant, and had significantly higher total cholesterol levels ( p = 0.002) compared to the stopped drinking group 7 years after transplant, even after adjusting for the use of lipid-lowering agents, age, sex, and body mass index. Although pretransplant and posttransplant alcohol consumption were not associated with major outcomes in KTRs during the median follow-up of 6.0 years, a new start of alcohol use after KT results in a relatively poor lipid profile. Clinical Trial Registration: clinicaltrials.gov , identifier NCT02042963.
Type of Medium:
Online Resource
ISSN:
1432-2277
DOI:
10.3389/ti.2022.10243
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
1463183-0
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