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  • 1
    In: Clinical Chemistry and Laboratory Medicine (CCLM), Walter de Gruyter GmbH, Vol. 53, No. 9 ( 2015-01-1)
    Abstract: Quantitative-fluorescent polymerase chain reaction (QF-PCR) is a reliable, rapid, and economic technique for prenatal diagnosis of the most common abnormalities. However, conventional karyotyping is expensive and requires a much longer time to yield results. It is currently under debate whether the replacement or restriction of karyotyping reduces the quality of prenatal test results. This study was undertaken to determine the percentage of clinically significant chromosomal abnormalities that would not be detected if QF-PCR was the main analysis method and karyotyping reserved for cases with increased nuchal translucency (NT) and/or abnormal ultrasound findings and to estimate the difference in cost between QF-PCR and full karyotyping. Nine hundred twenty-eight pregnant women underwent an invasive procedure at our center between May 2009 and December 2012, yielding 580 (62.5%) chorionic villous samples and 348 (37.5%) amniotic fluid samples. Samples were studied by both QF-PCR and full karyotyping. Karyotyping and detailed ultrasound findings were retrospectively analyzed. If QF-PCR was the main analytic method and full karyotyping reserved for cases with elevated NT (≥4.5) and/or abnormal ultrasound findings, 12.7% of the patients would have required full karyotyping, 99% of the clinically significant chromosomal abnormalities would have been detected, and the cost would have been 54% lower than a policy of full karyotyping for all. Detailed prenatal ultrasound scan can reduce the need for conventional karyotyping as a complement to QF-PCR in most prenatal samples, offering rapid results and reducing parental anxiety and healthcare costs.
    Type of Medium: Online Resource
    ISSN: 1437-4331 , 1434-6621
    Language: Unknown
    Publisher: Walter de Gruyter GmbH
    Publication Date: 2015
    detail.hit.zdb_id: 1492732-9
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Cordoba University Press (UCOPress) ; 2022
    In:  Hikma Vol. 21, No. 2 ( 2022-12-23), p. 321-345
    In: Hikma, Cordoba University Press (UCOPress), Vol. 21, No. 2 ( 2022-12-23), p. 321-345
    Abstract: As lecturers and researchers in translation and interpreting, we are aware of the need to design curricula so that students are well equipped, and able to respond to the requirements of modern society. In the world today, there is an evident gap between what is actually taught in higher education and what should be taught to meet student needs. Even though various studies have already focused on the impact of constructs, such as self-regulation, empathy, or creativity, on performance quality, there is still a long way to go. In order to bridge this gap and highlight the role of the university as a transformational agent, our study uses LifeComp, the European framework for the personal, social, and learning to learn key competence. The objective of this research was firstly to discover the transversal competences that are most highly valued by employers in the language industry sector; and secondly, to identify the competences that need more attention in curricula. For this purpose, a questionnaire-based study was designed and administered to translation companies based in Spain. The results obtained indicate that these competences are necessary to foster employability as well as real wealth creation in a lifelong learning context. This study is part of a broader project within the LifeComp framework, in which a competence-based psycho-educational intervention was designed and is now integrated in the translation and interpreting degree programme at the University of Granada (Spain). Keywords: Competence-based learning, LifeComp, Curriculum design, Higher education, Employability
    Type of Medium: Online Resource
    ISSN: 2445-4559 , 1579-9794
    URL: Issue
    Language: Unknown
    Publisher: Cordoba University Press (UCOPress)
    Publication Date: 2022
    detail.hit.zdb_id: 2945663-0
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