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  • 1
    Online Resource
    Online Resource
    Development and optimization of RP-HPLC method for analysis of cefpodoxime proxetil impurity in pharmaceutical formulation
    Universidad Tecnica de Manabi ; 2022
    In:  International journal of health sciences ( 2022-04-30), p. 7129-7151
    Details
    In: International journal of health sciences, Universidad Tecnica de Manabi, ( 2022-04-30), p. 7129-7151
    Abstract: The purpose of this research is to design and validate a unique, simple, and effective RP-HPLC analytical method using the QbD methodology. The QbD methodology not only confirms the method's robustness but also aids in the development of repeatable and reliable data. The goal of this work is to develop and validate a simple analytical RP-HPLC method for determining Cefpodoxime Impurity (Cefpodoxime Acid) in pharmaceutical formulations using the Analytical Quality by Design methodology (AQbd) in accordance with ICH Q8 guidelines. The Analytical Quality by Design technique was used in the proposed study. Cefpodoxime impurity (Cefpodoxime Acid) was chromatographically evaluated using an Inertsil C18 (5 m) column. The mobile phase was phosphate buffer and methanol pH 4.0 in the ratio of 60:40, which was driven onto the column at 0.8 ml/min using an isocratic elution protocol. 222 nm was discovered to be the detection wavelength for impurity estimation. Design expert 11 (Trial edition) software was used to investigate the effects of the mobile phase composition, flow rate, and pH. The analysis of cefpodoxime acid took 20 minutes to complete & at 15.6 minutes, the impurity was eluted. 
    Type of Medium: Online Resource
    ISSN: 2550-696X , 2550-6978
    URL: Issue
    URL: Article
    DOI: 10.53730/ijhs.v6nS2.2022
    DOI: 10.53730/ijhs.v6nS2.6778
    Language: Unknown
    Publisher: Universidad Tecnica de Manabi
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    EXPLORING HYPERTHYROIDISM WITH A NEUROLOGICAL OUTLOOK
    CAB PUBLISHER ; 2020
    In:  International Journal of Medical Science And Diagnosis Research Vol. 4, No. 12 ( 2020-12-17)
    Details
    In: International Journal of Medical Science And Diagnosis Research, CAB PUBLISHER, Vol. 4, No. 12 ( 2020-12-17)
    Abstract: Being one of the most common endocrinal disorders, the thyroid diseases having an extended spectrum from subclinical hypothyroidism to life threatening thyroid storm. Hyperthyroidism a hypermetabolic state with excess circulating thyroid hormones present as common systemic features like weight loss, palpitation, heat intolerance as well as peripheral and central nervous system manifestations.[1] Few of the initial neurological symptoms are often misdiagnosed as psychiatric disorders.
    Type of Medium: Online Resource
    ISSN: 2581-3935 , 2589-7837
    URL: Article
    DOI: 10.32553/ijmsdr.v4i12.727
    Language: Unknown
    Publisher: CAB PUBLISHER
    Publication Date: 2020
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  • 3
    Online Resource
    Online Resource
    Multiple sclerosis in pregnancy: meeting the challenges
    Medip Academy ; 2020
    In:  International Journal of Reproduction, Contraception, Obstetrics and Gynecology Vol. 9, No. 6 ( 2020-05-27), p. 2659-
    Details
    In: International Journal of Reproduction, Contraception, Obstetrics and Gynecology, Medip Academy, Vol. 9, No. 6 ( 2020-05-27), p. 2659-
    Abstract: Multiple sclerosis being a chronic, autoimmune inflammatory disease of central nervous system with its common and uncommon semiology has a predilection for women of child bearing age. The stressful period of pregnancy is further complicated with presence of multiple sclerosis. Overall multiple sclerosis has stabilising effect on pregnancy especially in its second and third trimester but adversely affects the post-partum period with increasing relapse rate. This is related with intense immune response triggered by marked changes in levels of circulating hormones. A better understanding of anti-natal, natal and post-partum effect of multiple sclerosis helps us to decide for institution or continuation of disease modifying drugs which are generally associated with favourable outcome.
    Type of Medium: Online Resource
    ISSN: 2320-1789 , 2320-1770
    URL: Article
    DOI: 10.18203/2320-1770.ijrcog20202067
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2020
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  • 4
    Online Resource
    Online Resource
    Gut microbiota: changing the disease architecture
    Medip Academy ; 2020
    In:  International Journal of Advances in Medicine Vol. 7, No. 6 ( 2020-05-22), p. 1032-
    Details
    In: International Journal of Advances in Medicine, Medip Academy, Vol. 7, No. 6 ( 2020-05-22), p. 1032-
    Abstract: Gut microflora comprising of trillions of various bacteria, protozoan, virus and fungi who live as a super-complex ecosystem in human body mostly (around 70%) in gastrointestinal tract. In habitating skin, mouth, intestine and sexual organs they live as symbiotic, commensal or pathogenic organism in the human body. These gut microflora interplay with bodily metabolic, immune, endocrinal and nervous system which leads to various pathophysiological mechanism for the causation of related disorders. This altered ‘Brain gut axis’ is responsible for disorders like anxiety, depression, autism, schizoaffective or bipolar disorder and also diseases like Parkinson’s disease and multiple sclerosis.1
    Type of Medium: Online Resource
    ISSN: 2349-3933 , 2349-3925
    URL: Article
    DOI: 10.18203/2349-3933.ijam20202077
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2020
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  • 5
    Online Resource
    Online Resource
    Noise pollution: it’s time to noise about
    Medip Academy ; 2020
    In:  International Journal of Advances in Medicine Vol. 7, No. 7 ( 2020-06-22), p. 1194-
    Details
    In: International Journal of Advances in Medicine, Medip Academy, Vol. 7, No. 7 ( 2020-06-22), p. 1194-
    Abstract: Carrying the reputation of silent killer of 21st century, ‘Noise’ a modern day pollutant is defined as an unpleasant, disharmonic and undesired acoustic signal. World Health Organization (WHO) has estimated it dimensions and warned that 10% of the population is exposed to both short and long term health related issues due to noise. Whilst facing the conflict between development and human health, the noise favors the present day industrialization and urbanization. The harmful effect of noise may start from intrauterine life and continues till old age. Noise of more than 85-95dB affects both the fetus and neonates by damaging the cochlear hair cell and results in high frequency hearing loss. At times prematurity, low birth rate and birth defects are also associated with exposure to high dB noise.
    Type of Medium: Online Resource
    ISSN: 2349-3933 , 2349-3925
    URL: Article
    DOI: 10.18203/2349-3933.ijam20202570
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2020
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  • 6
    Online Resource
    Online Resource
    Adult hypothyroidism and its neurological complications
    Medip Academy ; 2021
    In:  International Journal of Advances in Medicine Vol. 8, No. 2 ( 2021-01-27), p. 311-
    Details
    In: International Journal of Advances in Medicine, Medip Academy, Vol. 8, No. 2 ( 2021-01-27), p. 311-
    Abstract: Hypothyroidism is a clinical entity very commonly encountered in clinical practices. Untreated hypothyroidism can lead to hypertension, dyslipidemia, infertility, cognitive impairment, neurological and neuromuscular involvements. Neurological complications include reversible cerebellar ataxia, dementia, peripheral neuropathy, psychosis, coma, encephalopathy (Hashimoto's encephalopathy), neuromuscular disorders. The disease identification in the initial stage remains difficult as it presents with a large number of clinical features. Neonatal screening protocols in all patients of hypothyroidism can help in the timely detection as well as treatment. Most of the neurological manifestations can be reversed on timely administration of levothyroxine which works well even in reversing of the symptoms as it reverses the metabolic abnormalities. It is important to evaluate every patient with hypothyroidism or with the suspicion of the disease for any neurological abnormalities. 
    Type of Medium: Online Resource
    ISSN: 2349-3933 , 2349-3925
    URL: Article
    DOI: 10.18203/2349-3933.ijam20210088
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2021
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  • 7
    Online Resource
    Online Resource
    Vagus nerve stimulation in chronic refractory epilepsy: chasing the cardiologist
    Medip Academy ; 2021
    In:  International Journal of Advances in Medicine Vol. 8, No. 5 ( 2021-04-22), p. 732-
    Details
    In: International Journal of Advances in Medicine, Medip Academy, Vol. 8, No. 5 ( 2021-04-22), p. 732-
    Abstract: Epilepsy the second most common chronic neurological disorder after stroke affect 0.5-2% population worldwide. Antiepileptic drugs though remain the corner stone in management of epilepsy in majority of patients but still 30% of patients continues to have seizure or experience unacceptable pharmacological side effect. Electrical stimulation of vagus nerve is an effective and promising neurophysiological treatment for patients with refractory epilepsy who are either unsuitable candidate of surgery or falls in category of surgically refractory epilepsy. 
    Type of Medium: Online Resource
    ISSN: 2349-3933 , 2349-3925
    URL: Article
    DOI: 10.18203/2349-3933.ijam20211450
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2021
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  • 8
    Online Resource
    Online Resource
    A study of surgical site infections in a tertiary care hospital
    Medip Academy ; 2019
    In:  International Surgery Journal Vol. 6, No. 11 ( 2019-10-24), p. 3911-
    Details
    In: International Surgery Journal, Medip Academy, Vol. 6, No. 11 ( 2019-10-24), p. 3911-
    Abstract: Background: Health care-associated infections remain as an important public health concern. Surgical site infections (SSIs) are known to be one of the most common causes of nosocomial infections worldwide.Methods: A prospective observational study was conducted across 12 months (May 2018-April 2019) in a tertiary care hospital. The present study includes 223 patients who were undergoing clean and clean contaminated surgery in the hospital. Contaminated and dirty surgeries were excluded. The demographic data of the patient, diagnostic criteria used, associated risk factors, use of prophylactic antimicrobial agents, the type and duration of surgery, clinical evaluation of wound and laboratory data was collected. All the pus samples or wound swabs of clinically suspects of SSI cases received in the Department of Microbiology were inoculated and interpreted according to Centre for Disease Control and Infection guidelines.Results: The study included 223 patients who underwent surgery in the hospital. Amongst them 9 (4%) developed SSI. The incidence of SSI was 4.03%. There was a direct relationship observed between the occurrence of SSI and certain co-morbid conditions such as diabetes. It was also observed that prolonged surgeries above two hours and females were more predisposed to develop a surgical site infection.Conclusions: SSIs being one of the most common causes of nosocomial infections. It was also the most important factor responsible for significant morbidity, mortality, unwanted prolonged hospitalization and additional cost of treatment in surgical patients which can be reduced by strictly following the guidelines of infection control along with judicious and rational use of antibiotics.
    Type of Medium: Online Resource
    ISSN: 2349-2902 , 2349-3305
    URL: Article
    DOI: 10.18203/2349-2902.isj20194577
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2019
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  • 9
    Online Resource
    Online Resource
    Recognizing hypothyroidism from a neurologist eye: tips and tricks
    Medip Academy ; 2021
    In:  International Journal of Scientific Reports Vol. 7, No. 3 ( 2021-02-20), p. 194-
    Details
    In: International Journal of Scientific Reports, Medip Academy, Vol. 7, No. 3 ( 2021-02-20), p. 194-
    Abstract: 〈 p 〉 Hypothyroidism the most common endocrine disorder of adults with its protean neurological, neuropsychiatrical and neuromuscular manifestation needs special attention in clinical practice as majority of these symptoms can be reversed on timely administration of levothyroxine and attainment of euthyroid state, Thyroid hormones have critical influence on integral growth, development and functioning of central nervous system. Apart from usual clinical symptoms (especially in females) of constipation, fatigue, weight gain, cold intolerance, bradycardia and menstrual irregularities, the persistent low thyroid hormones can present with wide range of neurological complications like mononeuropathy (corpal tunnel syndrome) and polyneuropathy, cerebellar ataxia, dementia, psychosis, coma, encephalopathy (Hashimoto's) as well as myopathies. 〈 /p 〉
    Type of Medium: Online Resource
    ISSN: 2454-2164 , 2454-2156
    URL: Article
    DOI: 10.18203/issn.2454-2156.IntJSciRep20210549
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2021
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  • 10
    Online Resource
    Online Resource
    Gut microbiota: friend or foe
    Medip Academy ; 2020
    In:  International Journal of Research in Medical Sciences Vol. 9, No. 1 ( 2020-12-28), p. 322-
    Details
    In: International Journal of Research in Medical Sciences, Medip Academy, Vol. 9, No. 1 ( 2020-12-28), p. 322-
    Abstract: Comprising of trillions of various bacteria, protozoan, fungi and viruses, the gut microbiota live in human body as a super complex ecosystem mostly in gastro intestinal tract (70%). Apart from GI tract they also inhabit skin, mouth and sexual organs as an essential ecological community of commensal, symbiotic or even pathogenic relationship. These microbiota interplay with bodily immune, endocrinal, metabolic and nervous system and produces various pathological changes responsible for disease etiology. These microbiota play a major role in digestion and absorption of macro molecules, maturation of immune system, protection of gut and behavioural development of an individual. In gut disorders like inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS) the altered brain axis is responsible for disorders like depression, anxiety, schizoaffective disorders, autistic spectrum disorders, multiple sclerosis and parkinson’s disease. 
    Type of Medium: Online Resource
    ISSN: 2320-6012 , 2320-6071
    URL: Article
    DOI: 10.18203/2320-6012.ijrms20205660
    Language: Unknown
    Publisher: Medip Academy
    Publication Date: 2020
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