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  • 1
    In: Frontiers in Microbiology, Frontiers Media SA, Vol. 13 ( 2022-10-20)
    Abstract: Influenza A Virus (IAV) infection followed by bacterial pneumonia often leads to hospitalization and death in individuals from high risk groups. Following infection, IAV triggers the process of viral RNA replication which in turn disrupts healthy gut microbial community, while the gut microbiota plays an instrumental role in protecting the host by evolving colonization resistance. Although the underlying mechanisms of IAV infection have been unraveled, the underlying complex mechanisms evolved by gut microbiota in order to induce host immune response following IAV infection remain evasive. In this work, we developed a novel Maximal-Clique based Community Detection algorithm for Weighted undirected Networks (MCCD-WN) and compared its performance with other existing algorithms using three sets of benchmark networks. Moreover, we applied our algorithm to gut microbiome data derived from fecal samples of both healthy and IAV-infected pigs over a sequence of time-points. The results we obtained from the real-life IAV dataset unveil the role of the microbial families Ruminococcaceae, Lachnospiraceae, Spirochaetaceae and Prevotellaceae in the gut microbiome of the IAV-infected cohort. Furthermore, the additional integration of metaproteomic data enabled not only the identification of microbial biomarkers, but also the elucidation of their functional roles in protecting the host following IAV infection. Our network analysis reveals a fast recovery of the infected cohort after the second IAV infection and provides insights into crucial roles of Desulfovibrionaceae and Lactobacillaceae families in combating Influenza A Virus infection. Source code of the community detection algorithm can be downloaded from https://github.com/AniBhar84/MCCD-WN .
    Type of Medium: Online Resource
    ISSN: 1664-302X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587354-4
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  • 2
    Online Resource
    Online Resource
    GSC Online Press ; 2023
    In:  GSC Advanced Research and Reviews Vol. 14, No. 1 ( 2023-1-30), p. 188-198
    In: GSC Advanced Research and Reviews, GSC Online Press, Vol. 14, No. 1 ( 2023-1-30), p. 188-198
    Abstract: The purpose of this study is to investigate the quality of tubewell water (TW) in Barasat-I (Community Development Block) under North 24 Parganas District of Lower Gangetic Plain (LGP), West Bengal, India with respect to suitability for drinking purpose. This is the first micro-level ground water related study in this region. In total twenty (20) groundwater (GW) samples from tube-wells at different locations of nine (09) Gram Panchayats (GP) were collected and analyzed. The results have been compared with the Indian standard (IS) for drinking water based on eight parameters, such as pH, total dissolved solids (TDS), total suspended solid (TSS), conductivity, total alkalinity (TA), total hardness (TH), chloride (Cl), and arsenic (As). Moreover, TDS (50%) and Total Hardness (TH) (90%) were found to be above the desirable limit. However, pH, Chloride, has been found to be within the permissible limit. This micro-level study revealed that high contamination with arsenic of GW has been identified on the middle to eastern side of Barasat-I. As is found to be above acceptable limit at 70% sampling points. Therefore, rural people of the eastern side of the Barasat-I are prone to a higher risk of black-foot disease due to higher level of As. Overall, the groundwater in this block is not suitable and fit for direct drinking. It needs treatment to minimize pollution or contamination, where regular monitoring and analysis is recommended to determine the extent of contamination in the other parts of LGP. The findings of this study will be beneficial to manage and control ground water vulnerability in micro-level for water scientists, policy makers, and researchers as well in sustainable way and must be achieved by 2030.
    Type of Medium: Online Resource
    ISSN: 2582-4597
    URL: Issue
    Language: Unknown
    Publisher: GSC Online Press
    Publication Date: 2023
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  • 3
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Genetics Vol. 13 ( 2022-10-5)
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 13 ( 2022-10-5)
    Type of Medium: Online Resource
    ISSN: 1664-8021
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606823-0
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  • 4
    Online Resource
    Online Resource
    Frontiers Media SA ; 2023
    In:  Frontiers in Plant Science Vol. 14 ( 2023-3-3)
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 14 ( 2023-3-3)
    Abstract: Plant immune response is fascinating due to the complete absence of a humoral system. The adaptive immune response in plants relies on the intracellular orchestration of signalling molecules or intermediates associated with transcriptional reprogramming. Plant disease response phenomena largely depend on pathogen recognition, signal perception, and intracellular signal transduction. The pathogens possess specific pathogen-associated molecular patterns (PAMP) or microbe-associated molecular patterns (MAMP), which are first identified by pattern recognition receptors (PRRs) of host plants for successful infection. After successful pathogen recognition, the defence response is initiated within plants. The first line of non-specific defence response is called PAMP-triggered immunity (PTI), followed by the specific robust signalling is called effector-triggered immunity (ETI). Calcium plays a crucial role in both PTI and ETI. The biphasic induction of reactive oxygen species (ROS) is inevitable in any plant-microbe interaction. Calcium ions play crucial roles in the initial oxidative burst and ROS induction. Different pathogens can induce calcium accumulation in the cytosol ([Ca 2+ ] Cyt ), called calcium signatures. These calcium signatures further control the diverse defence-responsive proteins in the intracellular milieu. These calcium signatures then activate calcium-dependent protein kinases (CDPKs), calcium calmodulins (CaMs), calcineurin B-like proteins (CBLs), etc., to impart intricate defence signalling within the cell. Decoding this calcium ionic map is imperative to unveil any plant microbe interplay and modulate defence-responsive pathways. Hence, the present review is unique in developing concepts of calcium signature in plants and their subsequent decoding mechanism. This review also intends to articulate early sensing of calcium oscillation, signalling events, and comprehensive mechanistic roles of calcium within plants during pathogenic ingression. This will accumulate and summarize the exciting roles of calcium ions in plant immunity and provide the foundation for future research.
    Type of Medium: Online Resource
    ISSN: 1664-462X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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