In:
Clinical Chemistry and Laboratory Medicine (CCLM), Walter de Gruyter GmbH, Vol. 42, No. 8 ( 2004-01-1)
Abstract:
Cytochrome P450 1A2 (CYP1A2) is an important member of the cytochrome P450 superfamily of enzymes because of its involvement in the metabolism of some carcinogens and therapeutically important drugs. As a result, factors affecting the activity of the enzyme are the focus of considerable research effort as they may have important pharmacological or toxicological implications. CYP1A2 has been shown to exhibit a genetic polymorphism with most of the data, however, coming from studies in Caucasian and Oriental populations. In this study therefore, we investigated the frequencies of two point mutations, –163C 〉 A and 63C 〉 G, in two Bantu African populations. A total of 214 healthy subjects were recruited from Zimbabwe (n = 143) and Tanzania (n = 71). The two single nucleotide polymorphisms were detected using polymerase chain reaction-restriction fragment length polymorphism analysis. The frequency of –163A was 57% (95% confidence interval (CI), 54%, 60%) and 49% (95% CI, 45%, 53%) among Zimbabweans and Tanzanians, respectively, but the difference between the two populations was not statistically significant (p = 0.123). The base change 63C 〉 G was not found in any of the subjects from the two populations. We report here a high frequency of –163C 〉 A base change and an absence of the 63C 〉 G change in the two African populations.
Type of Medium:
Online Resource
ISSN:
1437-4331
,
1434-6621
DOI:
10.1515/CCLM.2004.152
Language:
Unknown
Publisher:
Walter de Gruyter GmbH
Publication Date:
2004
detail.hit.zdb_id:
1492732-9
SSG:
15,3
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