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  • 1
    Online-Ressource
    Online-Ressource
    Rehman Medical Institute, Peshawar, KP, Pakistan ; 2022
    In:  Journal of Rehman Medical Institute Vol. 7, No. 3 ( 2022-03-08), p. 03-08
    In: Journal of Rehman Medical Institute, Rehman Medical Institute, Peshawar, KP, Pakistan, Vol. 7, No. 3 ( 2022-03-08), p. 03-08
    Kurzfassung: Introduction: Khyber Pakhtunkhwa (KP), is geographically the smallest province, characterized by high population growth and a large refugee population. It faces a set of unique obstacles in the health sector including limited human resources, low financial protection, and weak governance. Objective: To explore clinical outcomes and factors associated with mortality among Health Care Workers (HCWs) of KPK. Materials & Methods: It was a cross sectional study conducted over 32 district of KP. A format containing 70 variables, including demographics, comorbidity, symptoms and outcomes, was developed and shared with rapid response teams (RRT) of each district and orientation was given for its use to the teams. Data were collected onto the software IPMS (Integrated Performance Monitoring System). We obtained this information from Health Department KP. Results: From February 2020 to 27th June 2020, 1813 HCWs reported COVID-19 positive; 669 had active infection, 1133 recovered while 11 died. Median age was 34 (IQR=14) years, and 76.1% were males. Fever, cough and sore throat were present in 40.5%, 33.5% and 19.1% while comorbidity was present in ~2% of patients. 6 patients were admitted to ICU and 4 patients received invasive ventilation- none survived. After adjusting for potential confounders, age, cough, Shortness of breath (SOB), headache, diabetes and chronic lung disease were significantly associated with mortality (all p 〈 0.05). Conclusion: HCWs, with COVID-19, were young; predominantly males, mostly asymptomatic, and a small proportion had comorbidity. Fever, cough and sore throat were top 3 symptoms. Mortality rate was 0.6%. The outcome was poor in patients who received intensive care/invasive ventilation.
    Materialart: Online-Ressource
    ISSN: 2708-8375 , 2708-8367
    Sprache: Unbekannt
    Verlag: Rehman Medical Institute, Peshawar, KP, Pakistan
    Publikationsdatum: 2022
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    Lahore Medical and Dental College ; 2022
    In:  Pakistan Journal of Medical and Health Sciences Vol. 16, No. 8 ( 2022-08-30), p. 338-341
    In: Pakistan Journal of Medical and Health Sciences, Lahore Medical and Dental College, Vol. 16, No. 8 ( 2022-08-30), p. 338-341
    Kurzfassung: Background: Progesterone is used in combined oral contraceptive pills and also has its effect on the respective receptors which are responsible for sexual development. Bronchial asthma emerges to be a major health issue in Pakistan with estimated prevalence is about 5% of the total population. Epidemiological studies highlight that one of the considerable risk factor for morbidity and mortality in inflammatory lung diseases is female gender. This suggests that sex-related hormones might play an imperative role in asthma disease progression. Understanding the biological role of sex hormones in regulating airway inflammation is crucial given the rising prevalence of chronic diseases among women worldwide. Aim: To determine the effect of progesterone on lungs of adult male mice by assessing and comparing the histological parameters e.g. bronchiolar smooth muscle size and peri-bronchial lymphocytic infiltration. Study Design: Randomized control trial Place and Duration of Study: Department of Physiology, Islamabad Medical & Dental College Islamabad in collaboration with National Institute of Health Islamabad from 1st October 2018 to 31st July 2019. Methodology: Sixty BALB/c mice were divided into 2 groups and each group comprised 30 mice. Group I (control group) received only distilled water and group 2 (norethisterone BP group) received pills mixed in distal water according to body weight of the mice respectively for 60 days. Results: In response to progesterone, 30% of the total mice had nil, 40% had mild, 26.7% of the total who showed moderate while severe PBLI was observed in 3.3% of the mice. Different frequencies of Bronchiolar Smooth Muscle Hyperplasia were observed when compared to Control group. Mild to moderate hyperplasia was produced by progesterone (norethisterone BP) group. Conclusion: Progesterone is the sexual hormone which modulates inflammatory processes in the lungs producing pulmonary inflammatory responses leading to asthma and also causes hyperplasia of the bronchiolar smooth muscles. Keywords: Progesterone, Asthma, Bronchiolar smooth muscle, Peri-bronchial lymphocytic Infiltration, BALB/c mice
    Materialart: Online-Ressource
    URL: Issue
    Sprache: Unbekannt
    Verlag: Lahore Medical and Dental College
    Publikationsdatum: 2022
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
    Online-Ressource
    Ubiquity Press, Ltd. ; 2020
    In:  Physical Activity and Health Vol. 4, No. 1 ( 2020-01-06), p. 1-
    In: Physical Activity and Health, Ubiquity Press, Ltd., Vol. 4, No. 1 ( 2020-01-06), p. 1-
    Materialart: Online-Ressource
    ISSN: 2515-2270
    Sprache: Unbekannt
    Verlag: Ubiquity Press, Ltd.
    Publikationsdatum: 2020
    ZDB Id: 2946837-1
    Standort Signatur Einschränkungen Verfügbarkeit
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