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  • 11
    Online Resource
    Online Resource
    Research on optimized SOC estimation algorithm based on extended kalman filter
    Frontiers Media SA ; 2022
    In:  Frontiers in Energy Research Vol. 10 ( 2022-9-21)
    Details
    In: Frontiers in Energy Research, Frontiers Media SA, Vol. 10 ( 2022-9-21)
    Abstract: The paper studies the estimation of state of charge (SOC) of batteries. Firstly, the research status of battery management system, battery equivalent model and SOC estimation algorithm is introduced, and the performance of common equivalent circuit model and SOC estimation algorithm in complexity and accuracy is compared and analyzed. On this basis, this paper proposes an extended Kalman filter (EKF) algorithm based on the first-order RC model, and optimizes it by piecewise fitting. The accuracy of the optimized EKF algorithm is greatly improved. Finally, the modeling and simulation are completed through MATLAB/SIMULINK, and the experimental platform is designed and built to test the SOC estimation algorithm based on EKF. The simulation and experimental results verify the accuracy of the estimation algorithm.
    Type of Medium: Online Resource
    ISSN: 2296-598X
    URL: Article
    DOI: 10.3389/fenrg.2022.1027439
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2733788-1
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  • 12
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    Enhancement in Selectivity of Coking Coal Flotation by Ultrasound Simultaneous Treatment
    Isaac Scientific Publishing Co., Ltd. ; 2020
    In:  Current Works in Mineral Processing Vol. 2, No. 1 ( 2020-3-31)
    Details
    In: Current Works in Mineral Processing, Isaac Scientific Publishing Co., Ltd., Vol. 2, No. 1 ( 2020-3-31)
    Type of Medium: Online Resource
    ISSN: 2663-7057 , 2663-7065
    URL: Journal
    URL: Article
    DOI: 10.22606/cwimp
    DOI: 10.22606/cwimp.2020.21001
    Language: Unknown
    Publisher: Isaac Scientific Publishing Co., Ltd.
    Publication Date: 2020
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  • 13
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    Parietal Lobe Reorganization and Widespread Functional Connectivity Integration in Upper-Limb Amputees: A rs-fMRI Study
    Frontiers Media SA ; 2021
    In:  Frontiers in Neuroscience Vol. 15 ( 2021-7-20)
    Details
    In: Frontiers in Neuroscience, Frontiers Media SA, Vol. 15 ( 2021-7-20)
    Abstract: The right parietal lobe plays an important role in body image, and disorders of body image emerge after lesions in the parietal lobe or with parietal lobe epilepsy. Body image disorder also often accompanies upper-limb amputation, in which the patient misperceives that their missing limb is still part of their body. Cortical reorganization is known to occur after upper-limb amputation, but it is not clear how widespread and to what degree functional connectivity (FC) is reorganized post-amputation, nor whether such changes might be related to misperceptions of body image. Twenty-four subjects who had a traumatically upper-limb amputees (ULAs) and 24 age-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging (rs-fMRI) scans. Regions of interest (ROIs) in the right superior parietal gyrus (SPG_R) and right inferior parietal lobule (IPL_R) were defined using BrainNet Viewer. We calculated the amplitude of low-frequency fluctuations (ALFF) in ROIs and correlated the ROI mean amplitude of low-frequency fluctuations (mALFF) and mean scores on the phantom limb sensation (PLS) scale and beck depression index (BDI). We also calculated ROIs and whole-brain FC. Compared to the HC group, we observed significantly increased activation (mALFF) in ROIs of the ULA group. Moreover, correlation analyses revealed a significant positive correlation between ROI mALFF and scores on the PLS. There was a significant negative correlation between the SPG_R mALFF and BDI scores. Seed-based, whole-brain FC analysis revealed that FC in the ULA group significantly decreased in many brain regions across the entire brain. The right parietal lobe appears to be involved in some aspect of body awareness and depression in amputation patients. Upper-limb amputation results not only in reorganization in the local brain area formerly representing the missing limb, but also results in more widespread reorganization through FC changes in whole brain.
    Type of Medium: Online Resource
    ISSN: 1662-453X
    URL: Article
    DOI: 10.3389/fnins.2021.704079
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2411902-7
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  • 14
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    Image_5.jpeg
    Frontiers Media SA ; 2022
    In:  Frontiers in Immunology Vol. 13 ( 2022-11-21)
    Details
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-11-21)
    Abstract: The systematic immune status of cancer patients undergoing immunotherapy is little known. We prospectively identified the function and differentiation traits of peripheral CD8 + T cells based on our phase 1b clinical trial (NCT03222440) of radiotherapy combined with camrelizumab in patients with locally advanced esophageal squamous cell carcinoma (ESCC) and compared it with concurrent chemoradiotherapy (CCRT). Methods 19 and 18 patients were included in the cohort of radiotherapy plus camrelizumab and cohort of CCRT treatment. By using flow cytometry, we evaluated the expression levels of PD-1, Eomes, T-bet and IFN-γ (function), CD38 and HLA-DR (activation), and differentiation subsets classified according to the expression levels of CD45RA and CD62L in peripheral CD8 + T cells before and during treatment. Results Effective binding of anti-PD-1 antibody camrelizumab with PD-1 on CD8 + T cells was detected during treatment. Both two treatments elevated the expression levels of activation molecules CD38 and HLA-DR on CD8 + T cells. PD-1 + CD8 + T cells had more activation features than PD-1 - CD8 + T cells in two groups and the treatments did not alter these differences. The two treatments activated both PD-1 + and PD-1 - CD8 + T cells. PD-1 + CD8 + T cells had less Naïve and TEMRA but more Tcm and Tem than PD-1 - CD8 + T cells in two groups and both two treatments changed the ratio of memory T cells in PD-1 + and PD-1 - cells. RT plus camrelizumab treatment reduced Naïve T cells and TEMRA subsets both in PD-1 + and PD-1 - CD8 + T cells while elevated Tcm subset in PD-1 + CD8 + T cells and Tem subset in PD-1 - CD8 + T cells. CCRT elevated Tcm subset and reduced TEMRA subset in PD-1 - CD8 + T cells while did not change any subset in PD-1 + CD8 + T cells. Furthermore, patients undergoing radiotherapy plus immunotherapy were found to obtain better prognosis than those receiving CCRT. Conclusions This study identified the dynamic changes of systematic immune status of patients undergoing treatment. The two treatments had similar activation effects on peripheral CD8 + T cells with different PD-1 properties but had different effects on their differentiation status. These results provided potential clues to the reasons underlying the difference in prognosis of the two treatments.
    Type of Medium: Online Resource
    ISSN: 1664-3224
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fimmu.2022.1060695
    DOI: 10.3389/fimmu.2022.1060695.s001
    DOI: 10.3389/fimmu.2022.1060695.s002
    DOI: 10.3389/fimmu.2022.1060695.s003
    DOI: 10.3389/fimmu.2022.1060695.s004
    DOI: 10.3389/fimmu.2022.1060695.s005
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606827-8
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  • 15
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    Table_2.xlsx
    Frontiers Media SA ; 2021
    In:  Frontiers in Oncology Vol. 11 ( 2021-11-29)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 11 ( 2021-11-29)
    Abstract: The aim of the study was to compare the clinical outcomes of induction chemotherapy (IC) followed by definitive concurrent chemoradiotherapy (dCCRT) versus chemoradiotherapy alone in patients with esophageal squamous cell carcinoma (ESCC) on the basis of a clinical scoring model. Methods A retrospective review of 599 patients with ESCC treated with dCCRT at our institution from 2010 to 2019 was conducted. The patients were divided into two groups based on whether they received IC. A clinical scoring model was performed using the significant variables obtained from the multivariate analysis. The PFS and OS rates were estimated using the Kaplan–Meier method. Results During the study period, 182 patients receiving IC followed by dCCRT and 417 dCCRT alone were identified. No significant differences in the PFS and OS rates were observed between the IC group (P=0.532) and the non-IC group (P=0.078). A clinical scoring model was constructed based on independent prognostic factors with scores ranging from 0 to 10.4. The patients were divided into high- and low-risk groups by using the median score as the cutoff value. The PFS rate of patients receiving IC was higher than that of patients treated without IC (P=0.034), while there was no improvement in the OS rate (P=0.794) in the high-risk group. No significant differences in the PFS (P=0.207) or OS (P=0.997) rate were found between the two treatment groups in the low-risk group. Conclusions The addition of IC followed by dCCRT for patients with ESCC might be associated with better PFS rates based on a clinical scoring model but has no impact on OS rates. Further prospective studies are warranted for the validation of this model.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2021.703074
    DOI: 10.3389/fonc.2021.703074.s001
    DOI: 10.3389/fonc.2021.703074.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2649216-7
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  • 16
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    Divergent coupling mechanism of precipitation on plant community multifunction across alpine grassland on the Tibetan Plateau
    Frontiers Media SA ; 2023
    In:  Frontiers in Plant Science Vol. 13 ( 2023-1-20)
    Details
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 13 ( 2023-1-20)
    Abstract: It is essential to understand plant adaptive strategies on plant stoichiometric traits at the species level rather than at the community level under various environmental conditions across the Tibetan Plateau (TP). Methods Here, plant community function and edaphic and meteorological factors were collected at 111 sites along an extensive water–heat gradient during the peak growing season in 2015. Community-weighted mean trait (CWM) was introduced to illuminating dynamics of the functional trait at the community level. Results Our results indicated that plant functional traits, including CWM-leaf total carbon (CWM_LTC), CWM-leaf total nitrogen (CWM_LTN), and CWM-leaf total phosphorus (CWM_LTP), showed similar and comparatively marked increases from alpine meadow (AM) to alpine steppe (AS). Moreover, since the tightly coordinated variation among each plant functional trait of AM was higher than that of AS, a more stable coupling mechanism of these plant functional traits could be observed in AM under a long-term evolutionary habit. Specifically, there was higher annual mean precipitation (AMP) in AM than that in AS significantly ( P & lt; 0.01), and AMP was significantly correlated with soil moisture and soil total phosphorus in AM. Generally, our findings suggest that precipitation determines divergent coupling plant community function in both AS and AM.
    Type of Medium: Online Resource
    ISSN: 1664-462X
    URL: Article
    DOI: 10.3389/fpls.2022.1122140
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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  • 17
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    Identification of a Novel COL4A4 Variant in Compound-Heterozygous State in a Patient With Alport Syndrome and Histological Findings Similar to Focal Segmental Glomerulosclerosis (FSGS)
    Frontiers Media SA ; 2019
    In:  Frontiers in Genetics Vol. 9 ( 2019-1-28)
    Details
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 9 ( 2019-1-28)
    Type of Medium: Online Resource
    ISSN: 1664-8021
    URL: Article
    DOI: 10.3389/fgene.2018.00748
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2019
    detail.hit.zdb_id: 2606823-0
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  • 18
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    Processing and 3D printing of Gradient Heterogeneous Bio-Model Based on Computer Tomography Images
    Institute of Electrical and Electronics Engineers (IEEE) ; 2016
    In:  IEEE Access Vol. 4 ( 2016), p. 8814-8822
    Details
    In: IEEE Access, Institute of Electrical and Electronics Engineers (IEEE), Vol. 4 ( 2016), p. 8814-8822
    Type of Medium: Online Resource
    ISSN: 2169-3536
    URL: Article
    DOI: 10.1109/ACCESS.2016.2635661
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2016
    detail.hit.zdb_id: 2687964-5
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  • 19
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    Prognostic values of the gross volume of metastatic lymph nodes in patients with esophageal squamous cell carcinoma treated with definitive concurrent chemoradiotherapy
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-11-10)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-11-10)
    Abstract: We aim to explore whether the gross volume of metastatic lymph nodes (GTVnd) and the gross volume of primary tumor (GTVp) could be prognostic factors for esophageal squamous cell carcinoma (ESCC) patients treated with definitive concurrent chemoradiotherapy (dCCRT). Methods We retrospectively analyzed 252 ESCC patients treated with dCCRT in the era of intensity-modulated radiation therapy (IMRT) at our institution. The cut-off value for the GTVnd derived from the restricted cubic splines (RCS) was determined. Univariate and multivariate Cox proportional hazard models were performed to determine the association between GTVnd and prognosis. we performed recursive partitioning analysis (RPA) method using GTVnd to develop a new risk stratification (TGTVndM). Moreover, the linear trend χ2, likelihood ratio χ2, and akaike information criterion (AIC) were used to determine the prognostic value between the TNM and TGTVndM staging systems. Results The five-year overall survival (OS) rate was 30.6%, with a median follow-up of 38 months. The cut-off value of GTVnd determined by the RCS was 4.35 cm 3 . GTVnd≥4.35 cm 3 was an independent and significant negative prognostic factor for OS (HR=1.949, P & lt;0.001), progression free survival (PFS) (HR=1.425, P=0.048), and distance metastasis free survival (DMFS) (HR=2.548, P=0.001). In multivariable analysis, gender, clinical T stage, and GTVnd were independently associated with OS. RPA segregated patients into 3 prognostic groups: high risk (T1-4 GTVnd≥4.35, n=126, III stage), intermediate risk (T4 GTVnd & lt;4.35,n=38,II stage), and low risk(T1-3GTVnd & lt;4.35, n=88, I stage). The 5-year OS(P & lt;0.001), PFS (P=0.002), and DMFS (P=0.001) were significantly worse in high-risk group in comparison with the intermediate and low risk groups. Compared with the TNM staging system, the clinical T stage combined with GTVnd (TGTVndM) had a higher linear trend χ2 (26.38 versus 25.77), higher likelihood ratio χ2 (24.39 versus 20.69), and lower AIC (1255.07 versus 1260.06). Conclusions GTVnd may serve as a good prognostic factor in predicting distant metastasis and death for ESCC patients treated with dCCRT. The TGTVndM staging system demonstrated superior accuracy for predicting OS and could serve as a more effective prognostic guidance for unresectable ESCC patients.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    DOI: 10.3389/fonc.2022.996293
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2649216-7
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  • 20
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    Data_Sheet_1.docx
    Frontiers Media SA ; 2022
    In:  Frontiers in Cardiovascular Medicine Vol. 9 ( 2022-7-29)
    Details
    In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-7-29)
    Abstract: Insulin resistance (IR) has emerged as a risk factor for coronary heart disease (CAD), but there is currently insufficient data on the association of non-insulin-based IR indexes [triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio, triglyceride and glucose (TyG) index, and metabolic score for IR (METS-IR)] with the presence and severity of CAD. Thus, the present study aimed to examine the relationship between these three non-insulin-based IR indexes and CAD, as well as to further compare the predictive values of each index. Materials and methods In total, 802 consecutive patients who underwent coronary angiography for suspected CAD from January 2016 to April 2017 were included in this study and were divided into the control group ( n = 149) and CAD group ( n = 653) according to the angiography results. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, triglyceride and glucose index (TyG index), and METS-IR were calculated according to the corresponding formulas. The severity of CAD was evaluated using the Gensini score (GS). The relationship of the TG/HDL-C ratio, TyG index, and METS-IR with CAD was analyzed, and the predictive values of the indexes were compared. Results The TG/HDL-C ratio, TyG index, and METS-IR in the CAD group were significantly higher than those in the control group. The TG/HDL-C ratio and METS-IR in the high GS group were significantly higher than those in the non-high GS group. Multivariate logistic regression analysis showed that the TG/HDL-C ratio and METS-IR were independent predictors for the presence of CAD {adjusted odds ratio (OR) [95% confidence interval (CI)]: 1.32 (1.02–1.70) and 1.65 (1.32–2.05), respectively}, whereas only the METS-IR was an independent predictor of the severity of CAD [adjusted OR (95% CI): 1.22 (1.02–1.47)] . Further subgroup analysis indicated that statistical significance was observed only among men, younger patients (≤ 60), and patients with prediabetes mellitus (PDM). Receiver operator characteristic (ROC) analysis showed that the METS-IR had the highest predictive value for the prediction of both the presence and severity of CAD. Conclusion The TG/HDL-C ratio, TyG index, and METS-IR are valuable predictors of the presence and severity of CAD, and the METS-IR has the highest predictive value among the three non-insulin-based IR indexes.
    Type of Medium: Online Resource
    ISSN: 2297-055X
    URL: Article
    URL: Article
    DOI: 10.3389/fcvm.2022.918359
    DOI: 10.3389/fcvm.2022.918359.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2781496-8
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