In:
Key Engineering Materials, Trans Tech Publications, Ltd., Vol. 361-363 ( 2007-11), p. 1013-1016
Abstract:
Globular-shaped beta-tricalcium phosphate (β-TCP) granules were synthesized using a unique
dropping slurry method and the biological response was analyzed by implantation into the rat femur. Two kinds of globular-shaped β-TCP granules, composed of either rod-shaped particles or conventional
non-rod-shaped particles were synthesized, implanted into the left femurs of 8-week-old female Wistar rats, and analyzed histologically. Commercially available β-TCP granules composed of conventional
non-rod-shaped particles were also implanted as a control experiment. Four weeks after the operation, part of each implant was already resorbed and the resorbed area was replaced by newly formed bone tissue
and bone marrow. Eight weeks after the operation, the resorption and replacement were advanced in each implant. At 12 weeks after the operation, residual globular-shaped β-TCP granules composed of
rod-shaped particles were resorbed into compact petrotic bone tissue almost completely. The formation of less compact petrotic bone tissue was observed in specimens implanted with globular-shaped β-TCP
granules composed of conventional non-rod-shaped particles. Commercially available β-TCP granules composed of conventional non-rod-shaped particles were mostly resorbed into trabecular bone and the
formation of compact petrotic bone tissue was rarely observed. These data suggested that both the unique spherical shape and microstructure of β-TCP particles affected bone-forming activity after the operation.
Type of Medium:
Online Resource
ISSN:
1662-9795
DOI:
10.4028/www.scientific.net/KEM.361-363
DOI:
10.4028/www.scientific.net/KEM.361-363.1013
Language:
Unknown
Publisher:
Trans Tech Publications, Ltd.
Publication Date:
2007
detail.hit.zdb_id:
2073306-9
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