In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 62, No. 3_Suppl ( 1969-12), p. S7-S46
Abstract:
Chlormadinone acetate (CMA) in a dose of 0.5 mg and Norethindrone (NET) in doses of 0.3 mg, 0.4 mg and 0.5 mg were administred daily to different groups of women. The groups consisted of between 104 and 125 individuals and the observation time varied between 1125 and 1850 months. The pregnancy rate varied between 0 and 3.2. There was a high frequency of irregular bleeding and amenorrhoea, causing 14.5% of the women to withdraw from trial. The cycle control seemed to be better with CMA 0.5 mg and NET 0.3 mg than with the two other doses of NET. The frequency of general side-effects was relatively low. Endometrial biopsies suggested, when cycles lasting less than 15 days were excluded, that between 70% and 80% of the vaginal flows followed periods of luteal activity. Judged by pregnanediol and progesterone determinations, the corresponding figures were 50% to 60%. This discrepancy is supposed to be due to reduced progesterone production of the corpus luteum, inducing irregular secretory changes of the endometrium. This is also supported by the fact that some women showed low plasma progesterone concentration simultaneously with irregular secretory endometrium. As the treatment was well tolerated by a majority of the participants and as it seems to have only minor metabolic effects, it is concluded that the method is a valuable complement to the other contraceptive measures available.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.064S007
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1969
detail.hit.zdb_id:
1485160-X
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