In:
Acta Endocrinologica, Oxford University Press (OUP), Vol. 116, No. 1 ( 1987-09), p. 108-112
Abstract:
Abstract. Multiple sc injections of a long-acting somatostatin analogue (SMS 201-995) are currently used in the treatment of acromegaly. However, plasma GH concentration often reaches a pathological level ( 〉 5 μg/l) between two injections. In seven patients with active acromegaly we compared, in a short-term trial, the effect of SMS 201-995 administered by continuous sc infusion (50 μg and 100 μg a day) and by three sc injections (100 μg each). In six patients, plasma GH levels were significantly reduced regardless of the mode and dose of treatment ( P 〈 0.05). However, comparing diurnal profiles, 100 μg continuous sc infusion was more effective than discontinuous administration in reducing the number of GH levels above 5 μg/l ( P 〈 0.01). In two patients, continuous infusion was the only way to decrease all plasma GH values below 5 μg/l during the diurnal profile determination. Moreover, even when, in a long-term study, the dose of multiple injections was progressively increased to 500 μg three times a day, GH levels remained consistently elevated in one of these patients. Thus, in some acromegalic patients continuous sc injection seems currently the most efficient way of treatment with SMS 201-995.
Type of Medium:
Online Resource
ISSN:
0804-4643
,
1479-683X
DOI:
10.1530/acta.0.1160108
Language:
Unknown
Publisher:
Oxford University Press (OUP)
Publication Date:
1987
detail.hit.zdb_id:
1485160-X
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