In:
American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 63, No. 12 ( 2002-12-01), p. 1641-1647
Abstract:
Objective —To evaluate the effect of feeding aspirin and
supplemental vitamin E on growth performance, lung lesions, plasma concentrations of 3-methylindole (3MI),
and 3-methyleneindolenine (3MEIN)-adduct concentrations in blood and pulmonary tissues of feedlot cattle. Animals —256 crossbred steers; 64 cattle were used in
experiment 1 and 192 cattle were used in experiment 2. Procedures —A 2 × 2 factorial design was used for
each experiment. Treatment factors were aspirin (0 or 3 g daily) and vitamin E (200 or 1,500 IU daily). Steers
were housed in pens (8 steers/pen). Steers were slaughtered on days 59 and 138 for experiments 1
and 2, respectively. Lungs were grossly evaluated. Plasma 3MI concentration was determined, and
3MEIN-adduct concentrations were measured in blood and pulmonary tissues. Results —Treatment was not associated with
improvement or adverse effects on weight gain, drymatter intake, or feed efficiency in experiment 2. In
experiment 1, 36 of 63 (57.1%) steers had lung lesions. Lesions were not associated with treatment
or concentrations of 3MI and 3MEIN-adduct. Plasma 3MI concentration and concentrations of 3MEINadduct
in blood and pulmonary tissues were 3.11 µg/mL, 0.51 U/µg of protein, and 0.49 U/µg of
protein, respectively. Aspirin was associated with increased blood concentrations of 3MEIN-adduct for
diets that did not contain supplemental vitamin E. Conclusions and Clinical Relevance —Differences in
performance of feedlot steers were not associated with treatment diet. It is possible that concurrent exposure of
feedlot cattle to other factors typically associated with development of respiratory tract disease would affect
these findings. ( Am J Vet Res 2002:63:1641–1647)
Type of Medium:
Online Resource
ISSN:
0002-9645
DOI:
10.2460/ajvr.2002.63.1641
Language:
Unknown
Publisher:
American Veterinary Medical Association (AVMA)
Publication Date:
2002
detail.hit.zdb_id:
2056942-7
SSG:
22
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