In:
Advanced Materials Research, Trans Tech Publications, Ltd., Vol. 881-883 ( 2014-1), p. 351-355
Abstract:
N , N' -dicyclohexyl-D-tartaric diamide 2a and N , N' -di-[( R )-inda-D-tartaric diamide 2b were prepared through the reaction of diethyl-D-tartrate with cyclohexylamine and ( R )-(-)-1-aminoindan, respectively. The two compounds coordinated with isopropyl titanate (Ti (O-iPr) 4 ), were used as catalyst in the asymmetric oxidation of pyrmetazol 3 with cumene hydroperoxide (CHP) as oxidant. The results revealed that both the catalytic systems derived from ligand 2a and 2b with Ti (O-iPr) 4 showed good catalytic activity and enantioselectivity in the synthesis of esomeprazole. Under the optimized conditions, the yield reached 91%, 91% and the enantio excess (ee) was up to 87% , 89%.
Type of Medium:
Online Resource
ISSN:
1662-8985
DOI:
10.4028/www.scientific.net/AMR.881-883
DOI:
10.4028/www.scientific.net/AMR.881-883.351
Language:
Unknown
Publisher:
Trans Tech Publications, Ltd.
Publication Date:
2014
detail.hit.zdb_id:
2265002-7
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