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  • 1
    Online Resource
    Online Resource
    MicroRNA‑mRNA integrated analysis based on a case of well‑differentiated thyroid cancer with both metastasis and metastatic recurrence
    Spandidos Publications ; 2018
    In:  Oncology Reports ( 2018-09-26)
    Details
    In: Oncology Reports, Spandidos Publications, ( 2018-09-26)
    Type of Medium: Online Resource
    ISSN: 1021-335X , 1791-2431
    URL: Journal
    URL: Article
    DOI: 10.3892/or
    DOI: 10.3892/or.2018.6739
    Language: Unknown
    Publisher: Spandidos Publications
    Publication Date: 2018
    detail.hit.zdb_id: 1222484-4
    detail.hit.zdb_id: 2120548-6
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  • 2
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    Changes in Morphological Characteristics, Regeneration Ability, and Polysaccharide Content in Tetraploid Dendrobium officinale
    American Society for Horticultural Science ; 2019
    In:  HortScience Vol. 54, No. 11 ( 2019-11), p. 1879-1886
    Details
    In: HortScience, American Society for Horticultural Science, Vol. 54, No. 11 ( 2019-11), p. 1879-1886
    Abstract: Dendrobium officinale Kimura et Migo is a famous traditional Chinese medicinal plant. It produces various phytochemicals, particularly polysaccharides, which have nutraceutical and pharmaceutical values. To increase its biomass production and polysaccharide content, our breeding program has generated a series of polyploid cultivars through colchicine treatment of protocorm-like bodies (PLBs). The present study compared two tetraploid cultivars, 201-1-T 1 and 201-1-T 2 , with their diploid parental cultivar, 201-1, in an established in vitro culture system. Tetraploid ‘201-1-T 1 ’ and ‘201-1-T 2 ’ had shorter leaves and shorter and thicker stems and roots, and they produced higher biomass compared with the diploid cultivar. The length and width of stomata significantly increased, but stomatal density decreased in tetraploid cultivars. The PLB induction rates from the stem node explants of the tetraploid cultivars were significantly higher than those of diploid. However, the PLB proliferation of tetraploids was lower than that of the diploid. The mean number of plantlets regenerated from tetraploid PLBs was also lower than that of the diploid after 4 months of culture. Polysaccharide contents in stems, leaves, and roots of 6-month-old tetraploid plantlets were significantly higher than those of diploids. The polysaccharide content in the stem of ‘201-1-T 1 ’ was 12.70%, which was a 2-fold increase compared with the diploid cultivar. Our results showed that chromosome doubling could be a viable way of improving D. officinale in biomass and polysaccharide production.
    Type of Medium: Online Resource
    ISSN: 0018-5345 , 2327-9834
    URL: Article
    DOI: 10.21273/HORTSCI14310-19
    Language: Unknown
    Publisher: American Society for Horticultural Science
    Publication Date: 2019
    detail.hit.zdb_id: 2040198-X
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  • 3
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    Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model
    Frontiers Media SA ; 2024
    In:  Frontiers in Pharmacology Vol. 15 ( 2024-2-21)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 15 ( 2024-2-21)
    Abstract: Objective: Psoralea corylifolia L. (FP) has received increasing attention due to its potential hepatotoxicity. Methods: In this study, zebrafish were treated with different concentrations of an aqueous extract of FP (AEFP; 40, 50, or 60 μg/mL), and the hepatotoxic effects of tonicity were determined by the mortality rate, liver morphology, fluorescence area and intensity of the liver, biochemical indices, and pathological tissue staining. The mRNA expression of target genes in the bile acid metabolic signaling pathway and lipid metabolic pathway was detected by qPCR, and the mechanism of toxicity was initially investigated. AEFP (50 μg/mL) was administered in combination with FXR or a peroxisome proliferator-activated receptor α (PPARα) agonist/inhibitor to further define the target of toxicity. Results: Experiments on toxic effects showed that, compared with no treatment, AEFP administration resulted in liver atrophy, a smaller fluorescence area in the liver, and a lower fluorescence intensity ( p & lt; 0.05); alanine transaminase (ALT), aspartate transaminase (AST), and γ-GT levels were significantly elevated in zebrafish ( p & lt; 0.01), and TBA, TBIL, total cholesterol (TC), TG, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were elevated to different degrees ( p & lt; 0.05); and increased lipid droplets in the liver appeared as fatty deposits. Molecular biological validation revealed that AEFP inhibited the expression of the FXR gene, causing an increase in the expression of the downstream genes SHP, CYP7A1, CYP8B1, BSEP, MRP2, NTCP, peroxisome proliferator-activated receptor γ (PPARγ), ME-1, SCD-1, lipoprotein lipase (LPL), CPT-1, and CPT-2 and a decrease in the expression of PPARα ( p & lt; 0.05). Conclusion: This study demonstrated that tonic acid extracts are hepatotoxic to zebrafish through the inhibition of FXR and PPARα expression, thereby causing bile acid and lipid metabolism disorders.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    DOI: 10.3389/fphar.2024.1308655
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 4
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    Image1.TIF
    Frontiers Media SA ; 2022
    In:  Frontiers in Pharmacology Vol. 13 ( 2022-8-30)
    Details
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-8-30)
    Abstract: Triptolide is a major compound isolated from the Tripterygium wilfordii Hook that is mainly used for the treatment of autoimmune disorders and inflammatory diseases. Though triptolide-induced hepatotoxicity has been widely reported, the hepatic effects when the patients are in an inflammatory state are not clear. In this study, we used low-dose Lipopolysaccharides (LPS) to disrupt the inflammation homeostasis in the liver of zebrafish and explored the hepatotoxicity of triptolide under an inflammatory state. Compared with the Triptolide group, LPS-Triptolide cotreatment exacerbate the liver injury with a remarkable decrease of liver size and liver-specific fluorescence intensity, accompanied by significant elevation of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities. Liver cell damages were further demonstrated by histological staining and scanning electron microscopy observation. Lipid metabolism was severely impaired as indicated by delayed yolk sac absorption, accumulated triglycerides in the liver, and dysregulation of the related genes, such as ppar-α , cpt-1 , mgst , srebf1/2 , and fasn . Oxidative stress could be involved in the molecular mechanism as the Nrf2/keap1 antioxidant pathways were down-regulated when the zebrafish in an inflammatory state. Moreover, the expression of autophagy-related genes such as beclin , atg5 , map1lc3b , and atg3 was also dysregulated. Finally, apoptosis was significantly induced in responses to LPS-Triptolide co-treatment. We speculate that triptolide could exacerbate the immune response and impair lipid metabolism, resulting in enhanced sensitivity of the zebrafish liver to triptolide-induced toxic effects through disruption of the antioxidant system and induction of apoptosis.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    URL: Article
    URL: Article
    DOI: 10.3389/fphar.2022.949312
    DOI: 10.3389/fphar.2022.949312.s001
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 5
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    Carbon-supported single-atom catalysts for advanced rechargeable metal-air batteries
    OAE Publishing Inc. ; 2022
    In:  Energy Materials Vol. 2, No. 3 ( 2022)
    Details
    In: Energy Materials, OAE Publishing Inc., Vol. 2, No. 3 ( 2022)
    Abstract: To address the fossil energy crisis and environmental problems, the urgent demand for clean energy has promoted the rapid development of advanced rechargeable metal-air batteries based on the redox reaction couples of gases, such as the oxygen reduction, oxygen evolution, carbon dioxide reduction and carbon dioxide evolution reactions. High-efficiency electrocatalysts are highly desirable to enhance the conversion efficiency of these reactions for enhancing battery performance. Significant advances in single-atom catalysts (SACs) on carbon matrices have been witnessed in recent years as attractive and unique systems to improve the electrocatalytic activities for high-performance rechargeable Zn- and Li-air batteries. This review summarizes the latest achievements in the applications of carbon-supported SACs in metal-air batteries, with a particular focus on the rational design of SACs and their fundamental electrocatalytic mechanism at the atomic level. The future development and perspectives of SACs in the field of metal-air batteries are also discussed.
    Type of Medium: Online Resource
    ISSN: 2770-5900
    URL: Journal
    URL: Article
    DOI: 10.20517/energymater
    DOI: 10.20517/energymater.2022.13
    Language: Unknown
    Publisher: OAE Publishing Inc.
    Publication Date: 2022
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  • 6
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    Online Resource
    Planning Pumped Storage Capacity for Wind Power Integration
    Institute of Electrical and Electronics Engineers (IEEE) ; 2013
    In:  IEEE Transactions on Sustainable Energy Vol. 4, No. 2 ( 2013-04), p. 393-401
    Details
    In: IEEE Transactions on Sustainable Energy, Institute of Electrical and Electronics Engineers (IEEE), Vol. 4, No. 2 ( 2013-04), p. 393-401
    Type of Medium: Online Resource
    ISSN: 1949-3029 , 1949-3037
    URL: Article
    DOI: 10.1109/TSTE.2012.2226067
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2013
    detail.hit.zdb_id: 2560005-9
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  • 7
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    Exploration of highly enhanced performance and resistive switching mechanism in hafnium doping ZnO memristive device
    IOP Publishing ; 2018
    In:  Semiconductor Science and Technology Vol. 33, No. 8 ( 2018-08-01), p. 085013-
    Details
    In: Semiconductor Science and Technology, IOP Publishing, Vol. 33, No. 8 ( 2018-08-01), p. 085013-
    Type of Medium: Online Resource
    ISSN: 0268-1242 , 1361-6641
    URL: Article
    DOI: 10.1088/1361-6641/aacff1
    RVK:
    UA 7761
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2018
    detail.hit.zdb_id: 54647-1
    detail.hit.zdb_id: 1361285-2
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  • 8
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    Facile Synthesis of MoO 3 Nanobelts with Carbon Dispersed Structure and Its Application As Anode of Lithium Ion Batteries
    The Electrochemical Society ; 2015
    In:  ECS Meeting Abstracts Vol. MA2015-01, No. 2 ( 2015-04-29), p. 580-580
    Details
    In: ECS Meeting Abstracts, The Electrochemical Society, Vol. MA2015-01, No. 2 ( 2015-04-29), p. 580-580
    Abstract: Lithium ion batteries (LIBs) have been successfully regarded as excellent power sources for energy conversion and storage technology, due to their high energy density, long lifespan, no memory and environmental benignity [1] . Transition metal oxides have been regarded as promising candidates for anode materials of LIBs due to their high theoretical capacity [ 2 ] . Molybdenum oxides (MoO 3 or MoO 2 ) have attracted enormous interest in recent decades, owing to their high thermal chemical stabilities and high theoretical capacity (e.g. 1117 mAh g -1 for MoO 3 and 838 mAh g -1 for MoO 2 ) [ 3 ] . In this paper, we design and fabricate a carbon dispersed structured α-MoO 3 nanobelts by a facile hydrothermal method. The addition of activated carbon is in an attempt to address the poor conductivity and also prevent the aggregation of the α-MoO 3 , consequently improve the rate capability and cycling stability of α-MoO 3 anode materials. The prepared MoO 3 /C nanobelts are systematically characterized by XRD, FTIR, TGA, SEM, TEM, and EDS techniques, and the electrochemical performance is investigated by CV and constant current discharge-charge test techniques. XRD analysis reveals that the as-synthesized material is α-MoO 3 . The addition of activated carbon has no influence on the crystal structure of α-MoO 3 . The peak positions of MoO 3 /C are as same as the pure MoO 3 , indicating that the existence of carbon does not affect the lattice structure of MoO 3 . FTIR analysis confirms the presence of carbon in the composite. The carbon content in MoO 3 /C composite was determined to be about 7.85% on the basis of the TGA analysis. The MoO 3 and MoO 3 /C samples are investigated as anode materials for LIBs. When tested at a current density of 100 mA g -1 between 0.01-3.0 V, the MoO 3 /C anode exhibits a much better cycling performance than the MoO 3 anode, delivering a higher discharge capacity of ~1000 mAh g -1 after 50 cycles. In contrast, the capacity of pure MoO 3 decreased continuously with the increasing number of cycles, only remains 632 mAh g -1 after 50 cycles. The improved cycling performance of MoO 3 /C can be attributed to the presence of activated carbon, which improves electronic conductivity. Moreover, the activated carbon prevents MoO 3 nanobelts agglomeration and acts as a sponge for relieving the large volume change during cycling, thus further enhance the structural stability. In summary, α-MoO 3 nanobelts with carbon dispersed structure can be fabricated through a one-pot hydrothermal method. When evaluated as anode materials for LIBs, the MoO 3 /C exhibit exceptional high specific capacity and outstanding rate capability The results suggested this kind of composite could become a promising candidate for anode materials of high-performance lithium ion batteries. References [1] Zhou X, Wan L J, Guo Y G. Advanced Materials, 2013, 25(15): 2152-2157. [2] Armand M, Tarascon J M. Nature, 2008, 451(7179): 652-657. [3] W. Wen and J. Wu, Appl. Mater. Interfaces (2011) 4112.
    Type of Medium: Online Resource
    ISSN: 2151-2043
    URL: Article
    DOI: 10.1149/MA2015-01/2/580
    Language: Unknown
    Publisher: The Electrochemical Society
    Publication Date: 2015
    detail.hit.zdb_id: 2438749-6
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  • 9
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    Table8.XLSX
    Frontiers Media SA ; 2022
    In:  Frontiers in Molecular Biosciences Vol. 9 ( 2022-4-11)
    Details
    In: Frontiers in Molecular Biosciences, Frontiers Media SA, Vol. 9 ( 2022-4-11)
    Abstract: Accurate timing of seasonal changes is an essential ability for an animal’s survival, and the change in the photoperiod is the key factor affecting reproductive seasonality in mammals. Emerging evidence has suggested that multiple hypothalamic genes participate in the photoperiod-induced regulation of reproductive activities in sheep, but the mechanism is still unclear. In this study, we initially examined the plasma level of two major reproductive hormones, namely, follicle-stimulating hormone (FSH) and prolactin (PRL), under different photoperiods in ovariectomized and estradiol-treated (OVX + E 2 ) sheep using radioimmunoassay (RIA). Of the two hormones, the concentration of PRL significantly increased with the extension of the photoperiod, while FSH showed the opposite trend. Subsequently, an examination of the transcriptomic variation between the short photoperiod (SP) and long photoperiod (LP) was conducted. Differential expression analyses and functional annotation showed that several key genes in the insulin secretion ( VAMP2 , PRKACB , PRKCG , and PLCB1 ), GnRH ( MAPK13 , CGA , CDC42 , ATF4 , and LHB ) pathways, and circadian entrainment ( KCNJ5 , PER1 , GNB2 , MTNR1A , and RASD1 ), as well as numerous lncRNAs, including XR_173257.3, XR_173415.3, XR_001435315.1, XR_001024596.2, and XR_001023464.2, were shown potentially vital for the hypothalamic photoperiodic response. Four of the differentially expressed mRNAs and lncRNAs were validated by qPCR. The constructed mRNA–mRNA interaction networks further revealed that transcripts potentially participated in hypothalamic thyroid hormone synthesis, endocrine resistance, and neuroactive ligand–receptor interactions. The interactome analysis of lncRNAs and their targets implied that XR_173257.3 and its target arylalkylamine N-acetyltransferase ( AANAT ) and XR_173415.3 and its target TH might participate in the regulation of seasonal reproduction. Together, the changes in reproductive hormones and transcriptome will help to determine the important photoperiod-induced lncRNAs and mRNAs and provide a valuable resource for further research on reproductive seasonality in sheep.
    Type of Medium: Online Resource
    ISSN: 2296-889X
    URL: Article
    URL: Article
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    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fmolb.2022.848144
    DOI: 10.3389/fmolb.2022.848144.s001
    DOI: 10.3389/fmolb.2022.848144.s002
    DOI: 10.3389/fmolb.2022.848144.s003
    DOI: 10.3389/fmolb.2022.848144.s004
    DOI: 10.3389/fmolb.2022.848144.s005
    DOI: 10.3389/fmolb.2022.848144.s006
    DOI: 10.3389/fmolb.2022.848144.s007
    DOI: 10.3389/fmolb.2022.848144.s008
    DOI: 10.3389/fmolb.2022.848144.s009
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2814330-9
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  • 10
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    Data_Sheet_2.xls
    Frontiers Media SA ; 2021
    In:  Frontiers in Veterinary Science Vol. 8 ( 2021-8-3)
    Details
    In: Frontiers in Veterinary Science, Frontiers Media SA, Vol. 8 ( 2021-8-3)
    Abstract: The pituitary pars tuberalis (PT) is the regulating center of seasonal reproduction, which can sense the melatonin signal and eventually cause downstream changes of GnRH secretion through TSHβ. Recently, lncRNAs have been identified in animal reproductive-related tissues, and they play important roles in reproductive regulation. Therefore, in this study, we expect to identify photoperiod-induced lncRNAs and genes in pituitary PT of sheep by comparison of expression profiles between short photoperiod (SP) and long photoperiod (LP). Through RNA-Seq, a total of 55,472 lncRNAs were identified in pituitary PT of Sunite ewes. The number of differentially expressed (DE) genes and lncRNAs between SP and LP increased gradually with the extension of LP (from LP7 to LP42). The notable LP-induced candidate genes included EYA3, TSHB, SIX1, DCT, VMO1, AREG, SUV39H2 , and EZH2 , and SP-induced genes involved ENSOARG00000012585, CHGA, FOS, SOCS3 , and TH . In enriched pathways for DE genes and lncRNA target genes between SP and LP, the reproduction- and circadian-related pathways were highlighted. In addition, the interactome analysis of lncRNAs and their targets implied that MSTRG.209166 and its trans -target TSHB, MSTRG.288068 and its cis -target SIX1 , and ENSOARG00000026131 and its cis -target TH might participate in regulation of seasonal reproduction. Together, these results will help to determine important photoperiod-induced lncRNAs and genes and give us some new insights into the epigenetic regulation of seasonal reproduction in sheep.
    Type of Medium: Online Resource
    ISSN: 2297-1769
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fvets.2021.644474
    DOI: 10.3389/fvets.2021.644474.s001
    DOI: 10.3389/fvets.2021.644474.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2021
    detail.hit.zdb_id: 2834243-4
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