In:
Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 9 ( 2021-10-6)
Abstract:
Damage to intestinal epithelial cell proliferation or intestinal stem cell (ISC) maintenance may trigger inflammatory bowel disease (IBD), and protecting the ISCs is critical for IBD treatment. Here, we found that in the dextran sulfate sodium (DSS)-induced ulcerative colitis mice model, colon epithelium and Lgr5 + intestinal stem cells (ISCs) renew quickly during the first 3 days. We also found that during this renewing period, SMAD4 and bone morphogenetic protein 4 (BMP4) expression were significantly upregulated. An extra BMP4 treatment could preserve the Lgr5 + ISCs and the colon epithelium turnover, and could significantly decrease colon mucosal damage. Moreover, we found that BMP4 regulated ID3 expression in the colon epithelium. Depletion of ID3 could significantly reduce the epithelium renewal and ratio of Lgr5 + ISCs at the base of crypts. In conclusion, the present study showed that BMP4 could maintain epithelium cellular proliferation and the ISCs function through ID3 in mice with DSS-induced colitis. The administration of exogenous BMP4 supplement could alleviate DSS-induced colitis by restoring epithelium cellular proliferation and ISC function, suggesting the possible therapeutic function of BMP4 for ulcerative colitis.
Type of Medium:
Online Resource
ISSN:
2296-634X
DOI:
10.3389/fcell.2021.700864
DOI:
10.3389/fcell.2021.700864.s001
DOI:
10.3389/fcell.2021.700864.s002
DOI:
10.3389/fcell.2021.700864.s003
DOI:
10.3389/fcell.2021.700864.s004
DOI:
10.3389/fcell.2021.700864.s005
DOI:
10.3389/fcell.2021.700864.s006
DOI:
10.3389/fcell.2021.700864.s007
DOI:
10.3389/fcell.2021.700864.s008
DOI:
10.3389/fcell.2021.700864.s009
DOI:
10.3389/fcell.2021.700864.s010
DOI:
10.3389/fcell.2021.700864.s011
DOI:
10.3389/fcell.2021.700864.s012
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2021
detail.hit.zdb_id:
2737824-X
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