In:
Frontiers in Immunology, Frontiers Media SA, Vol. 11 ( 2020-12-23)
Abstract:
Type I interferon is widely used for antiviral therapy, yet has yielded disappointing results toward chronic HBV infection. Here we identify that PEG-IFNα-2b therapy toward persistent infection in humans is a double-edged sword of both immunostimulation and immunomodulation. Our studies of this randomised trial showed persistent PEG-IFNα-2b therapy induced large number of CD24 + CD38 hi B cells and launched a CD24 + CD38 hi B cells centered immunosuppressive response, including downregulating functions of T cells and NK cells. Patients with low induced CD24 + CD38 hi B cells have achieved an improved therapeutic effect. Specifically, using the anti-CD24 antibody to deplete CD24 + CD38 hi B cells without harming other B cell subsets suggest a promising strategy to improve the therapeutic effects. Our findings show that PEG-IFNα-2b therapy toward persistent infection constitutes an immunomodulation effect, and strategies to identifying the molecular basis for the antiviral versus immunomodulatory effects of PEG-IFNα-2b to selectively manipulate these opposing activities provide an opportunity to ameliorate anti-virus immunity and control viral infection.
Type of Medium:
Online Resource
ISSN:
1664-3224
DOI:
10.3389/fimmu.2020.591269
DOI:
10.3389/fimmu.2020.591269.s001
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2020
detail.hit.zdb_id:
2606827-8
Permalink