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  • 1
    Online Resource
    Online Resource
    IOP Publishing ; 2022
    In:  Journal of Physics D: Applied Physics Vol. 55, No. 14 ( 2022-04-07), p. 145302-
    In: Journal of Physics D: Applied Physics, IOP Publishing, Vol. 55, No. 14 ( 2022-04-07), p. 145302-
    Abstract: High sensitivity, wide working range and flexible portability of strain sensors are crucial for smart wearable applications. To obtain these performances, several elastic melt-blown nonwoven substrates with excellent flexibility and high conductivity were developed by loading with polypyrrole through a double-dipping and double-rolling finishing method. The structure and conductivity are characterized by scanning electron microscope, infrared spectrometer, digital source meter and so on. The results indicate that the conductivity of prepared substrates is affected by the pyrrole concentration and polypyrrole amount deposited in nonwovens. Obviously, the conductivity and sensitivity of substrates as strain sensors are highly and positively correlated to the fiber orientation in nonwovens, and the effective working range and corresponding sensitivity of sensors are determined by the elastic deformation interval of melt-blown substrate. When the pyrrole concentration is 5.5%, the nonwoven substrate with 45.30% porosity possesses the anisotropic optimal conductivity with 23.491 S m −1 along winding direction and 15.063 S m −1 along width direction. Moreover, the as-prepared flexible conductive substrate exhibits the characteristics of wide working strain range (0%–24.2%), high sensitivity with 1.94 gauge factor at the range, fast response (0.023 s), tiny hysteresis (0.011 s), high durability and stability after 1000 cycles. Furthermore, the as-prepared sensor provides an effective method to prepare smart wearable strain sensors used as the monitor of finger bending in details and the precise recognition of human voice changes.
    Type of Medium: Online Resource
    ISSN: 0022-3727 , 1361-6463
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2022
    detail.hit.zdb_id: 209221-9
    detail.hit.zdb_id: 1472948-9
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  • 2
    Online Resource
    Online Resource
    IOP Publishing ; 2020
    In:  Journal of Physics D: Applied Physics Vol. 53, No. 19 ( 2020-05-06), p. 195403-
    In: Journal of Physics D: Applied Physics, IOP Publishing, Vol. 53, No. 19 ( 2020-05-06), p. 195403-
    Type of Medium: Online Resource
    ISSN: 0022-3727 , 1361-6463
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 209221-9
    detail.hit.zdb_id: 1472948-9
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  • 3
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Cell and Developmental Biology Vol. 10 ( 2022-5-25)
    In: Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 10 ( 2022-5-25)
    Abstract: Minichromosome maintenance 2 (MCM2) is a member of the minichromosomal maintenance family of proteins that mainly regulates DNA replication and the cell cycle and is involved in regulating cancer cell proliferation in various cancers. Previous studies have reported that MCM2 plays a pivotal role in cell proliferation and cancer development. However, few articles have systematically reported the pathogenic roles of MCM2 across cancers. Therefore, the present pan-cancer study was conducted. Various computational tools were used to investigate the MCM2 expression level, genetic mutation rate, and regulating mechanism, immune infiltration, tumor diagnosis and prognosis, therapeutic response and drug sensitivity of various cancers. The expression and function of MCM2 were examined by Western blotting and CCK-8 assays. MCM2 was significantly upregulated in almost all cancers and cancer subtypes in The Cancer Genome Atlas and was closely associated with tumor mutation burden, tumor stage, and immune therapy response. Upregulation of MCM2 expression may be correlated with a high level of alterations rate. MCM2 expression was associated with the infiltration of various immune cells and molecules and markedly associated with a poor prognosis. Western blotting and CCK-8 assays revealed that MCM2 expression was significantly upregulated in melanoma cell lines. Our results also suggested that MCM2 promotes cell proliferation in vitro by activating cell proliferation pathways such as the Akt signaling pathways. This study explored the oncogenic role of MCM2 across cancers, provided data on the underlying mechanisms of these cancers for further research and demonstrated that MCM2 may be a promising target for cancer immunotherapy.
    Type of Medium: Online Resource
    ISSN: 2296-634X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2737824-X
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  • 4
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Aging Neuroscience Vol. 14 ( 2022-2-1)
    In: Frontiers in Aging Neuroscience, Frontiers Media SA, Vol. 14 ( 2022-2-1)
    Abstract: The epidemiological features of Guillain-Barré syndrome (GBS) were different in different areas; a comparison of the disease was needed to identify the variation and prognosis. We compare the epidemiological features of GBS in different areas in China. Method A total of 1,191 patients were included. Information was collected in patients diagnosed with GBS and its variants in middle and south China, and then retrospectively reviewed. The patients were divided into four different regions: East China ( n = 441), Center China ( n = 566), South China ( n = 77), and Southwest China ( n = 107). These subregions are mainly divided by climate and geographical location. These data were compared with data from a study in East China (Shandong, n = 150) and Northeast China (Changchun, n = 750). Results Patients from the south and southwest China were younger than other regions ( P = 0.000). A summer peak and an autumn peak were found in northern China, but more patients in winter and spring days in other areas ( P = 0.000). Upper respiratory tract infection (URTI) was the preceding event of GBS patients in all regions but rarer in central China ( P = 0.001). The proportion of axonal subtype was higher in central and southwest China than in other regions ( P = 0.001). Patients in southwest China were more served at nadir and have the longest hospital stay ( P = 0.003 and P = 0.000). Conclusion The difference between seasonal variation and preceding events was found in different regions in China; clinical features differ among regions in China.
    Type of Medium: Online Resource
    ISSN: 1663-4365
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2558898-9
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  • 5
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Surgery Vol. 9 ( 2022-5-11)
    In: Frontiers in Surgery, Frontiers Media SA, Vol. 9 ( 2022-5-11)
    Abstract: The growing number of patients undergoing total hip arthroplasty (THA) and postoperative outcomes receive increasing attention from doctors and patients. This study aimed to elucidate the effects of comorbidities on postoperative function, pain, complications, readmission rate, and mortality. Methods We included consecutive patients who underwent primary unilateral THA between 2017 and 2019. The Charlson comorbidity index (CCI) and the WOMAC and SF-36 (physical function, body pain) scales were assessed preoperatively and at 3, 6, 12, and 24 months postoperatively. The complications, 30-day readmission, and mortality rates assessed the impact of comorbidities and their changes over time on the WOMAC and SF-36 scores during follow-up. We used mixed model linear regression to examine the association of worsening comorbidity post-THA with change in WOMAC and SF-36 scores in the subsequent follow-up periods, controlling for age, length of follow-up, and repeated observations. Results This study included 468 patients, divided into four groups based on comorbidity burden (CCI-0, 1, 2, and ≥3). The physiological function recovery and pain scores in the CCI ≥ 3 group were inferior to the other groups and took longer than the other groups (6 vs. 3 months) to reach their best level. The four groups preoperative waiting times were 2.41 ± 0.74, 2.97 ± 0.65, 3.80 ± 0.53, and 5.01 ± 0.71 days, respectively. The complications, 30-day readmission, and 1-year mortality rates for the overall and the CCI ≥ 3 group were 1.92% and 4.69%, 0.85% and 2.01%, and 0.43% and 1.34%, respectively, with no mortality in the other groups. Conclusion Patients with higher CCI were more susceptible to physical function and pain outcome deterioration, experienced longer waiting time before surgery, took longer to recover, and had higher rates of complications, 30-day readmission, and mortality after THA. Older age in the group led to a greater impact.
    Type of Medium: Online Resource
    ISSN: 2296-875X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2773823-1
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  • 6
    Online Resource
    Online Resource
    African Journals Online (AJOL) ; 2023
    In:  Tropical Journal of Pharmaceutical Research Vol. 21, No. 12 ( 2023-02-02), p. 2541-2548
    In: Tropical Journal of Pharmaceutical Research, African Journals Online (AJOL), Vol. 21, No. 12 ( 2023-02-02), p. 2541-2548
    Abstract: Purpose: To elucidate the role of AKAP12 in leukemia cells.Methods: Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) and Western blotting (WB) were employed to determine the expression of AKAP12 in leukocyte cell lines, while 5-azacytidine was used to treat the cells, followed by assessment of the expression of AKAP12. After constructing the overexpressing vector pc-AKAP12 and transfecting it into cells or treating the cells with 5-azacytidine, cell counting kit-8 assay (CCK-8) was used to determine cell proliferation. Cloning ability of the cells was evaluated by colony formation assay.  Furthermore, flow cytometry was employed to measure the degrees of cell cycle and cell apoptosis. The effect of AKAP12 on PI3K/AKT were determined by western blot.Results: The results showed that AKAP12 was lowly expressed in lymphocytic leukemia cell lines (p 〈 0.001), but was reversed by 5-azacytidine. Transfection of AKAP12 or 5-azacytidine treatment increased the expression of AKAP12 in the cells (p 〉 0.001), inhibited leukemia cell proliferation and clonality, and arrested cell cycle in G1 phase as well as induced apoptosis. In addition, PI3K/AKT signaling pathway was inhibited by AKAP12.Conclusion: AKAP12 is lowly expressed in leukemia cells, and may also play a role in inhibiting leukemia progression by suppressing the activity of PI3K/AKT pathway.Thus, targeting AKAP12 mght be a potential strategy in the management of lukemia.
    Type of Medium: Online Resource
    ISSN: 1596-9827 , 1596-5996
    Language: Unknown
    Publisher: African Journals Online (AJOL)
    Publication Date: 2023
    detail.hit.zdb_id: 2125881-8
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2020
    In:  IEEE Transactions on Power Delivery Vol. 35, No. 5 ( 2020-10), p. 2558-2560
    In: IEEE Transactions on Power Delivery, Institute of Electrical and Electronics Engineers (IEEE), Vol. 35, No. 5 ( 2020-10), p. 2558-2560
    Type of Medium: Online Resource
    ISSN: 0885-8977 , 1937-4208
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2020
    detail.hit.zdb_id: 165807-4
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  • 8
    Online Resource
    Online Resource
    Scientific Research Publishing, Inc. ; 2011
    In:  International Journal of Communications, Network and System Sciences Vol. 04, No. 07 ( 2011), p. 456-463
    In: International Journal of Communications, Network and System Sciences, Scientific Research Publishing, Inc., Vol. 04, No. 07 ( 2011), p. 456-463
    Type of Medium: Online Resource
    ISSN: 1913-3715 , 1913-3723
    Language: Unknown
    Publisher: Scientific Research Publishing, Inc.
    Publication Date: 2011
    detail.hit.zdb_id: 2642124-0
    detail.hit.zdb_id: 2639944-1
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  • 9
    Online Resource
    Online Resource
    DEStech Publications ; 2017
    In:  DEStech Transactions on Environment, Energy and Earth Sciences , No. icnerr ( 2017-09-18)
    In: DEStech Transactions on Environment, Energy and Earth Sciences, DEStech Publications, , No. icnerr ( 2017-09-18)
    Type of Medium: Online Resource
    ISSN: 2475-8833
    Language: Unknown
    Publisher: DEStech Publications
    Publication Date: 2017
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  • 10
    Online Resource
    Online Resource
    DEStech Publications ; 2017
    In:  DEStech Transactions on Environment, Energy and Earth Sciences , No. icnerr ( 2017-09-18)
    In: DEStech Transactions on Environment, Energy and Earth Sciences, DEStech Publications, , No. icnerr ( 2017-09-18)
    Type of Medium: Online Resource
    ISSN: 2475-8833
    Language: Unknown
    Publisher: DEStech Publications
    Publication Date: 2017
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