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  • 1
    Online Resource
    Online Resource
    Frontiers Media SA ; 2023
    In:  Frontiers in Oncology Vol. 13 ( 2023-1-25)
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 13 ( 2023-1-25)
    Abstract: Krüppel-like factors (KLFs) are a group of DNA-binding transcriptional regulators with multiple essential functions in various cellular processes, including proliferation, migration, inflammation, and angiogenesis. The aberrant expression of KLFs is often found in tumor tissues and is essential for tumor development. At the molecular level, KLFs regulate multiple signaling pathways and mediate crosstalk among them. Some KLFs may also be molecular switches for specific biological signals, driving their transition from tumor suppressors to promoters. At the histological level, the abnormal expression of KLFs is closely associated with tumor cell stemness, proliferation, apoptosis, and alterations in the tumor microenvironment. Notably, the role of each KLF in tumors varies according to tumor type and different stages of tumor development rather than being invariant. In this review, we focus on the advances in the molecular biology of KLFs, particularly the regulations of several classical signaling pathways by these factors, and the critical role of KLFs in tumor development. We also highlight their strong potential as molecular targets in tumor therapy and suggest potential directions for clinical translational research.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2649216-7
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  • 2
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2023
    In:  IEEE Transactions on Automation Science and Engineering
    In: IEEE Transactions on Automation Science and Engineering, Institute of Electrical and Electronics Engineers (IEEE)
    Type of Medium: Online Resource
    ISSN: 1545-5955 , 1558-3783
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2023
    detail.hit.zdb_id: 2155780-9
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  • 3
    Online Resource
    Online Resource
    International Information and Engineering Technology Association ; 2020
    In:  Traitement du Signal Vol. 37, No. 1 ( 2020-02-29), p. 85-93
    In: Traitement du Signal, International Information and Engineering Technology Association, Vol. 37, No. 1 ( 2020-02-29), p. 85-93
    Type of Medium: Online Resource
    ISSN: 0765-0019
    URL: Issue
    Language: Unknown
    Publisher: International Information and Engineering Technology Association
    Publication Date: 2020
    detail.hit.zdb_id: 2174628-X
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  • 4
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 11 ( 2023-2-1)
    Abstract: In conventional sequence stratigraphy research, owing to the limitation of the resolution of seismic data, strata can only be divided into third order sequences at most on the seismic profile. In this study, the vertical fourth order sequence is divided using the high vertical resolutions of gamma ray (GR), uranium (U), thorium (Th), and potassium (K) curves in the logging curves, and the sequence divided in the depth system is then accurately superimposed on the seismic profile through one dimensional forward modelling. Subsequently, through three dimensional Fourier transform technology, the dip angle and azimuth information of the seismic data in the entire region are scanned to obtain the horizons. Through the progradation and retrogradation characteristics of sediments in the Wheeler system, guided by the sequence framework, the horizontal interpretation of the fourth order sequence system tract is conducted in the entire region. Finally, through attribute optimisation, the root mean square amplitude attribute, with the highest degree of coincidence with well data, is selected to study the evolution characteristics of sedimentary microfacies in different periods in the four system tracts. Notably, the strata of Qixia Formation in the study area can be divided into two-fourth order sequences, wherein SQ1 comprised transgressive systems tract 1 (TST1) and high stand systems tract 1 (HST1), and SQ2 comprised TST2 and HST2. With the change in the relative sea level cycle, the strata of Qixia Formation in the study area are developed by overlapping the sedimentary microfacies of the interbank depression, interbank sea, and intraplatform shoal from bottom to top.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2741235-0
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  • 5
    Online Resource
    Online Resource
    International Information and Engineering Technology Association ; 2020
    In:  Traitement du Signal Vol. 37, No. 5 ( 2020-11-25), p. 807-813
    In: Traitement du Signal, International Information and Engineering Technology Association, Vol. 37, No. 5 ( 2020-11-25), p. 807-813
    Abstract: The float glass contains various defects for reasons of raw materials and production process. These defects can be observed on the end images of the glass. Since the defects are correlated with specific links of the production process, it is possible to discover the process problems by identifying the location and type of defects in end images. Based on faster region-based convolutional neural network (Faster RCNN), this paper proposes a deep learning method that improves the feature extraction network, and adds a Laplacian convolutional layer to preprocess the end images. Considering the defect features in end images, the anchor box size was adjusted to speed up the training. Besides, the lack of generalizability induced by small dataset was solved through data enhancement. With improved VGG16 as the feature extraction layer, a glass defect detection model was established, whose generalizability was improved through transfer learning. The experimental results show that the proposed model achieved a mean detection accuracy of 94% on actual test set, meeting the requirements for actual use in factories.
    Type of Medium: Online Resource
    ISSN: 0765-0019 , 1958-5608
    URL: Issue
    Language: Unknown
    Publisher: International Information and Engineering Technology Association
    Publication Date: 2020
    detail.hit.zdb_id: 2174628-X
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  • 6
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Physiology Vol. 13 ( 2022-6-20)
    In: Frontiers in Physiology, Frontiers Media SA, Vol. 13 ( 2022-6-20)
    Abstract: Fibrosis can occur in many organs, and severe cases leading to organ failure and death. No specific treatment for fibrosis so far. In recent years, microRNA-34a (miR-34a) has been found to play a role in fibrotic diseases. MiR-34a is involved in the apoptosis, autophagy and cellular senescence, also regulates TGF-β1/Smad signal pathway, and negatively regulates the expression of multiple target genes to affect the deposition of extracellular matrix and regulate the process of fibrosis. Some studies have explored the efficacy of miR-34a-targeted therapies for fibrotic diseases. Therefore, miR-34a has specific potential for the treatment of fibrosis. This article reviews the important roles of miR-34a in fibrosis and provides the possibility for miR-34a as a novel therapeutic target in fibrosis.
    Type of Medium: Online Resource
    ISSN: 1664-042X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2564217-0
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  • 7
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Endocrinology Vol. 13 ( 2022-9-8)
    In: Frontiers in Endocrinology, Frontiers Media SA, Vol. 13 ( 2022-9-8)
    Abstract: Kidney dysfunction is particularly important in systemic organ injuries caused by aging. Metabolomics are utilized in this study to explore the mechanism of kidney dysfunction during aging by the identification of metabolites and the characterization of metabolic pathways. We analyzed the serum biochemistry and kidney histopathology of male Kunming mice aged 3 months and 24 months and found that the aged mice had inflammatory lesions, aggravated fibrosis, and functional impairment. A high-resolution untargeted metabolomics analysis revealed that the endogenous metabolites in the kidneys and urine of the mice were significantly changed by 25 and 20 metabolites, respectively. A pathway analysis of these differential metabolites revealed six key signaling pathways, namely, D-glutamine and D-glutamate metabolism, purine metabolism, the citrate cycle [tricarboxylic acid (TCA) cycle], histidine metabolism, pyruvate metabolism, and glyoxylate and dicarboxylate metabolism. These pathways are involved in amino acid metabolism, carbohydrate metabolism, and nucleotide metabolism, and these can lead to immune regulation, inflammatory responses, oxidative stress damage, cellular dysfunction, and bioenergy disorders, and they are closely associated with aging and kidney insufficiency. We also screened nine types of sensitive metabolites in the urine as potential biomarkers of kidney dysfunction during the aging process to confirm their therapeutic targets in senior-induced kidney dysfunction and to improve the level of risk assessment for senile kidney injury.
    Type of Medium: Online Resource
    ISSN: 1664-2392
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2592084-4
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