In:
International Letters of Chemistry, Physics and Astronomy, AOA Academic Open Access Ltd., Vol. 14 ( 2013-9), p. 68-86
Abstract:
Some 2′,4′-difluorophenyl chalcones have been synthesized under microwave irradiation using aldol condensation between 2,4-difluoroacetophenone and substituted benzaldehydes using catalytic amount of hydroxyapatite. The yields of the chalcones are more than 85%. The purities of these synthesized chalcones were examined by their physical constants and spectroscopic data. The UV absorption maxima (λmax, nm), infrared stretches (ν, cm -1 ) of CO, fingerprint region of CH ip / op , CH=CH op , C=C op modes, NMR chemical shifts (δ, ppm) of vinyl proton, carbon and carbonyl carbons have been assigned and correlated with Hammett substituent constants, F and R parameters using single and multi-regression analysis. From the statistical analysis the effect of substituent on the above spectral frequencies can be discussed. The antimicrobial activities of these synthesized chalcones have been screened using Bauer-Kirby method.
Type of Medium:
Online Resource
ISSN:
2299-3843
DOI:
10.18052/www.scipress.com/ILCPA.14
DOI:
10.18052/www.scipress.com/ILCPA.14.68
Language:
Unknown
Publisher:
AOA Academic Open Access Ltd.
Publication Date:
2013
detail.hit.zdb_id:
2780525-6
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