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  • 1
    Online Resource
    Online Resource
    Lacunes may worsen cognition but not motor function in Parkinson's disease
    Wiley ; 2023
    In:  Brain and Behavior Vol. 13, No. 2 ( 2023-02)
    Details
    In: Brain and Behavior, Wiley, Vol. 13, No. 2 ( 2023-02)
    Abstract: Lacunes were independently associated with worse visual scanning, attention, and processing speed in patients with Parkinson's disease (PD). Lacunes may accelerate the course of PD. Early treatment of vascular disease provides an alternate way to mitigate some motor and cognitive dysfunction in patients with PD.
    Type of Medium: Online Resource
    ISSN: 2162-3279 , 2162-3279
    URL: Issue
    URL: Article
    DOI: 10.1002/brb3.v13.2
    DOI: 10.1002/brb3.2880
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2623587-0
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  • 2
    Online Resource
    Online Resource
    The impact of cerebral small vessel disease burden and its imaging markers on gait, postural control, and cognition in Parkinson’s disease
    Springer Science and Business Media LLC ; 2023
    In:  Neurological Sciences Vol. 44, No. 4 ( 2023-04), p. 1223-1233
    Details
    In: Neurological Sciences, Springer Science and Business Media LLC, Vol. 44, No. 4 ( 2023-04), p. 1223-1233
    Type of Medium: Online Resource
    ISSN: 1590-1874 , 1590-3478
    URL: Article
    DOI: 10.1007/s10072-022-06563-1
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 1481772-X
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  • 3
    Online Resource
    Online Resource
    Altered Neurovascular Coupling for Multidisciplinary Intensive Rehabilitation in Parkinson's Disease
    Society for Neuroscience ; 2023
    In:  The Journal of Neuroscience Vol. 43, No. 7 ( 2023-02-15), p. 1256-1266
    Details
    In: The Journal of Neuroscience, Society for Neuroscience, Vol. 43, No. 7 ( 2023-02-15), p. 1256-1266
    Abstract: Effective rehabilitation in Parkinson's disease (PD) is related to brain reorganization with restoration of cortico–subcortical networks and compensation of frontoparietal networks; however, further neural rehabilitation evidence from a multidimensional perspective is needed. To investigate how multidisciplinary intensive rehabilitation treatment affects neurovascular coupling, 31 PD patients (20 female) before and after treatment and 30 healthy controls (17 female) underwent blood oxygenation level-dependent functional magnetic resonance imaging and arterial spin labeling scans. Cerebral blood flow (CBF) was used to measure perfusion, and fractional amplitude of low-frequency fluctuation (fALFF) was used to measure neural activity. The global CBF–fALFF correlation and regional CBF/fALFF ratio were calculated as neurovascular coupling. Dynamic causal modeling (DCM) was used to evaluate treatment-related alterations in the strength and directionality of information flow. Treatment reduced CBF–fALFF correlations. The altered CBF/fALFF exhibited increases in the left angular gyrus and the right inferior parietal gyrus and decreases in the bilateral thalamus and the right superior frontal gyrus. The CBF/fALFF alteration in right superior frontal gyrus showed correlations with motor improvement. Further, DCM indicated increases in connectivity from the superior frontal gyrus and decreases from the thalamus to the inferior parietal gyrus. The benefits of rehabilitation were reflected in the dual mechanism, with restoration of executive control occurring in the initial phase of motor learning and compensation of information integration occurring in the latter phase. These findings may yield multimodal insights into the role of rehabilitation in disease modification and identify the dorsolateral superior frontal gyrus as a potential target for noninvasive neuromodulation in PD. SIGNIFICANCE STATEMENT Although rehabilitation has been proposed as a promising supplemental treatment for PD as it results in brain reorganization, restoring cortico–subcortical networks and eliciting compensatory activation of frontoparietal networks, further multimodal evidence of the neural mechanisms underlying rehabilitation is needed. We measured the ratio of perfusion and neural activity derived from arterial spin labeling and blood oxygenation level-dependent fMRI data and found that benefits of rehabilitation seem to be related to the dual mechanism, restoring executive control in the initial phase of motor learning and compensating for information integration in the latter phase. We also identified the dorsolateral superior frontal gyrus as a potential target for noninvasive neuromodulation in PD patients.
    Type of Medium: Online Resource
    ISSN: 0270-6474 , 1529-2401
    URL: Article
    DOI: 10.1523/JNEUROSCI.1204-22.2023
    Language: English
    Publisher: Society for Neuroscience
    Publication Date: 2023
    detail.hit.zdb_id: 1475274-8
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Table_1.DOCX
    Frontiers Media SA ; 2022
    In:  Frontiers in Aging Neuroscience Vol. 14 ( 2022-6-16)
    Details
    In: Frontiers in Aging Neuroscience, Frontiers Media SA, Vol. 14 ( 2022-6-16)
    Abstract: Rehabilitation has been proposed as a valid measure complementary to the management of Parkinson's disease (PD). However, the mechanism underlying is not clear yet. The differential expressions of exosomal messenger RNA (mRNA) and long noncoding RNAs (lncRNAs) may play a critical role in PD progression and rehabilitation. To compare the differential expressions of exosomal mRNAs and lncRNAs, patients with PD (PWPs, Hoehn and Yahr stages 1.5-2.5, n = 6) and age- and sex-matched healthy controls (HCs, n = 6) were included in this study. All PWPs received a 2-week rehabilitation treatment in the hospital, which seemingly led to improvement in both the motor and non-motor functions. A set of differentially expressed mRNAs (DEmRNAs) and differentially expressed lncRNAs (DElncRNAs) extracted from exosomes in blood samples via next-generation sequencing (NGS) was screened out. Compared to HCs, 2,337 vs. 701 mRNAs and 1,278 vs. 445 lncRNAs were significantly upregulated and significantly downregulated, respectively, in pre-rehabilitation (pre-rehab) PWPs; 2,490 vs. 629 mRNAs and 1,561 vs. 370 lncRNAs were significantly upregulated and significantly downregulated, respectively, in post-rehabilitation (post-rehab) PWPs. Compared to pre-rehab PWPs, 606 vs. 1,056 mRNAs and 593 vs. 1,136 lncRNAs were significantly upregulated and significantly downregulated, respectively, in post-rehab PWPs. Overall, 14 differentially expressed mRNAs (DEmRNAs) and 73 differentially expressed lncRNAs (DElncRNAs) were expressed in the blood exosomes of HCs, pre- and post-rehab PWPs, simultaneously. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses identified 243 significantly co-expressed lncRNA-mRNA pairs. One DEmRNA of interest (ENSG00000099795, NDUFB7) and three corresponding DElncRNAs (ENST00000564683, ENST00000570408, and ENST00000628340) were positively related. Quantitative real-time polymerase chain reaction (qRT-PCR) validated that the expression levels of NDUFB7 mRNA and the 3 DElncRNAs increased significantly in pre-rehab PWPs, but decreased significantly in post-rehab PWPs compared to HCs. NDUFB7 mRNA is a marker related to mitochondrial respiration. It is reasonably believed that mitochondrial function is associated with PD rehabilitation, and the mitochondrial pathway may involve in the pathogenesis of PD.
    Type of Medium: Online Resource
    ISSN: 1663-4365
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fnagi.2022.909622
    DOI: 10.3389/fnagi.2022.909622.s001
    DOI: 10.3389/fnagi.2022.909622.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2558898-9
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  • 5
    Online Resource
    Online Resource
    Quality of life predicts rehabilitation prognosis in Parkinson's disease patients : Factors influence rehabilitation prognosis
    Wiley ; 2022
    In:  Brain and Behavior Vol. 12, No. 5 ( 2022-05)
    Details
    In: Brain and Behavior, Wiley, Vol. 12, No. 5 ( 2022-05)
    Abstract: Rehabilitation has been reported to improve the quality of life (QoL) of patients with Parkinson's disease (PD). Nevertheless, not all patients are satisfied with rehabilitation outcomes and could achieve a significant improvement in QoL. Objective To detect possible predictors of QoL improvement in patients with PD after rehabilitation. Methods A total of 86 PD patients were included and followed up for 3 months with a 39‐item Parkinson's Disease Questionnaire summary index (PDQ‐39 SI) as the primary endpoint. All patients received 2 weeks of multidisciplinary intensive rehabilitation treatment (MIRT). Changes in patients' QoL were assessed using the PDQ‐39 at baseline and at the 3‐month follow‐up. The reliable change index (RCI) was adapted to determine the individual QoL outcome. The predictors of QoL outcome were detected using logistic regression analysis. Results After a 3‐month follow‐up, PDQ‐39 SI decreased significantly from 22.95 ± 9.75 to 18.73 ± 10.32 ( P   〈  0.001). Scores for QoL improved (RCI 〉 10.9) after rehabilitation for 18.6% of the patients, and 74.4% of patients reported an unchanged QoL (−10.9≤RCI≤10.9), while 7.0% of patients reported a worsening of QoL (RCI 〈 −10.9). Among the baseline parameters, the PDQ‐39 SI was a baseline predictor for changes in QoL in the logistic regression model (OR: 1.15, CI: 1.07–1.24, P   〈  0.001). Conclusions MIRT could improve QoL for some patients with PD, and PDQ‐39 score at baseline is the most important predictor for QoL improvements after rehabilitation for this patients.
    Type of Medium: Online Resource
    ISSN: 2162-3279 , 2162-3279
    URL: Issue
    URL: Article
    DOI: 10.1002/brb3.v12.5
    DOI: 10.1002/brb3.2579
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2623587-0
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  • 6
    Online Resource
    Online Resource
    Circular RNAs in Parkinson’s Disease: Reliable Biological Markers and Targets for Rehabilitation
    Springer Science and Business Media LLC ; 2023
    In:  Molecular Neurobiology Vol. 60, No. 6 ( 2023-06), p. 3261-3276
    Details
    In: Molecular Neurobiology, Springer Science and Business Media LLC, Vol. 60, No. 6 ( 2023-06), p. 3261-3276
    Type of Medium: Online Resource
    ISSN: 0893-7648 , 1559-1182
    URL: Article
    DOI: 10.1007/s12035-023-03268-0
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2079384-4
    SSG: 12
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