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  • 1
    In: Environmental Research Letters, IOP Publishing, Vol. 16, No. 9 ( 2021-09-01), p. 094055-
    Abstract: Given the reported increasing trends in high Asian streamflow and rapidly increasing water demand in the Indian subcontinent, it is necessary to understand the long‐term changes and mechanisms of snow- and glacier-melt-driven streamflow in this area. Thus, we have developed a June–July streamflow reconstruction for the upper Indus River watershed located in northern Pakistan. This reconstruction used a temperature-sensitive tree-ring width chronology of Pinus wallichiana , and explained 40.9% of the actual June–July streamflow variance during the common period 1970–2008. The high level of streamflow (1990–2017) exceeds that of any other time and is concurrent with the impact of recent climate warming that has resulted in accelerated glacier retreats across high Asia. The streamflow reconstruction indicated a pronounced reduction in streamflow in the upper Indus River basin during solar minima (Maunder, Dalton, and Damon). Shorter periods (years) of low streamflow in the reconstruction corresponded to major volcanic eruptions. Extreme low and high streamflows were also linked with sea surface temperature. The streamflow reconstruction also provides a long-term context for recent high Asian streamflow variability resulting from seasonal snow and glaciers that is critically needed for water resources management and assessment.
    Type of Medium: Online Resource
    ISSN: 1748-9326
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2021
    detail.hit.zdb_id: 2255379-4
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  • 2
    Online Resource
    Online Resource
    Frontiers Media SA ; 2023
    In:  Frontiers in Plant Science Vol. 14 ( 2023-5-17)
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 14 ( 2023-5-17)
    Abstract: Citrus reticulata ‘Chachi’ peel (CRCP), which is named “Guangchenpi” in China, is a geographical indication product with unique flavor properties. CRCP has been used for centuries as a traditional genuine herb because of its excellent therapeutic effects. In addition, owing to its unique odor and high nutrition, it is widely used in various food preparations. Volatile organic compounds (VOCs) are regarded as an important quality marker for CRCP and are highly susceptible to effects in the drying process due to their thermal instability. Methods In the current study, the main VOCs in CRCP were processed using different drying methods, including sun-drying, hot air drying, and vacuum-freeze drying. The VOCs were identified by the electronic nose (E-nose), gas chromatography-ion mobility spectrometry (GC-IMS), and headspace solid-phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS). Results The results showed that the CRCP dried by vacuum-freeze exhibited the highest VOCs contents and retained the richest compounds compared to those dried by other methods, which indicated that vacuum-freeze drying is the most suitable for CRCP production. Furthermore, the chemometrics analysis revealed that the primary differential metabolites of the samples generated using different drying methods were terpenes and esters. Discussion Overall, our study would help better understand the VOCs present in CRCP with different drying methods. The outcomes of the current study would guide the drying and processing of CRCP, which is beneficial for large-scale storage and industrial production of CRCP.
    Type of Medium: Online Resource
    ISSN: 1664-462X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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  • 3
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2020
    In:  IEEE Access Vol. 8 ( 2020), p. 210640-210650
    In: IEEE Access, Institute of Electrical and Electronics Engineers (IEEE), Vol. 8 ( 2020), p. 210640-210650
    Type of Medium: Online Resource
    ISSN: 2169-3536
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2020
    detail.hit.zdb_id: 2687964-5
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  • 4
    In: Oncology Letters, Spandidos Publications, ( 2018-05-18)
    Type of Medium: Online Resource
    ISSN: 1792-1074 , 1792-1082
    Language: Unknown
    Publisher: Spandidos Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2573196-8
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  • 5
    In: Frontiers in Immunology, Frontiers Media SA, Vol. 10 ( 2019-3-29)
    Type of Medium: Online Resource
    ISSN: 1664-3224
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2019
    detail.hit.zdb_id: 2606827-8
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  • 6
    Online Resource
    Online Resource
    Frontiers Media SA ; 2024
    In:  Frontiers in Plant Science Vol. 15 ( 2024-3-14)
    In: Frontiers in Plant Science, Frontiers Media SA, Vol. 15 ( 2024-3-14)
    Abstract: Dendrobium is an epiphytic herb plant with neuroprotective, gastroprotective, anti-inflammatory, and immunomodulatory effects. It is often found attached to tree trunks or rocks. With the development of the dendrobium industry, numerous epiphytic patterns exist, such as crushed stone, stump, and sawdust. The study of metabolites and endophytes of D. nobile under different epiphytic patterns, which revealed the effects of epiphytic patterns on D. nobile from the perspectives of metabolomics and microbiology, is of great significance for the healthy development of D. nobile . Methods In the study, the D. nobile under five epiphytic patterns grown in the same environment were selected. The metabolites were investigated by widely targeted metabolomics, and the endophytes were sequenced using high-throughput sequencing methods. Then, a correlation analysis between the different metabolites and endophytes was performed. Results A total of 1,032 metabolites were annotated in D. nobile . There are more flavonoids and phenolic acids accumulated on the epiphytic pattern of Danxia stone, whereas the accumulation of lipids on the other epiphytic patterns and 16 differential metabolites was screened out. The endophyte composition of D. nobile was dominated by Proteobacteria , Actinomycetes , unidentified bacteria, Firmicutes , and Cyanobacteria . For endophytic fungi, Basidiomycota and Ascomycota were the dominant phyla of D. nobile . The relative abundance of Spirosoma , Nocardioides , and Arrhenia in the Danxia stone was significantly higher than that of other epiphytic patterns. According to correlation analysis, we found a significant correlation between differential metabolites and Spirosoma , Nocardioides , and Arrheni . Discussion This study confirmed that Dendrobium quality was affected by its epiphytic patterns and revealed its possible causes from a microbiological point of view.
    Type of Medium: Online Resource
    ISSN: 1664-462X
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2024
    detail.hit.zdb_id: 2687947-5
    detail.hit.zdb_id: 2613694-6
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  • 7
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Earth Science Vol. 10 ( 2022-5-20)
    In: Frontiers in Earth Science, Frontiers Media SA, Vol. 10 ( 2022-5-20)
    Abstract: Mid-to-high latitudes of Asia and its adjacent Arctic area are some of the most sensitive regions to climate warming in Eurasia, but spatio-temporal temperature variation over this region is still limited by a lack of long-term temperature records. Here, June-July temperature reconstructions are developed from a Larix sibirica composite chronology that presents a stable positive linkage with large-scale recorded temperatures and spans 1190–2019 CE for the source area of the Northern Asian great river Basins, northern Mongolian Plateau, Inner Asia. The warmest reconstructed period and low summer sea ice extent in the Arctic Ocean over the past 830 years was estimated to occur in the late twentieth century (1990s–present), with a mean temperature (15.2°C) higher than the long-term mean (13.9°C) of 1190–2019 CE, which is linked with the rapid increase in global temperature. A relationship also exists between the reconstructed temperature and the AMO index, suggesting that the atmospheric patterns over the Arctic and North Atlantic Oceans influence the temperature variations of northern Mongolian Plateau. In addition, we also propose that the warm climate promoted high vegetation productivity and favored the formation of power of the nomadic tribes in the Mongolian Plateau, such as the warm periods 1210s–1250s and 1400s–1430s. Our temperature reconstruction provides us with an opportunity to understand the regional effects of climate warming from multiple perspectives.
    Type of Medium: Online Resource
    ISSN: 2296-6463
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2741235-0
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  • 8
    Online Resource
    Online Resource
    Society of Glass Technology ; 2015
    In:  Glass Technology: European Journal of Glass Science and Technology Part A Vol. 56, No. 1 ( 2015-2-21), p. 21-27
    In: Glass Technology: European Journal of Glass Science and Technology Part A, Society of Glass Technology, Vol. 56, No. 1 ( 2015-2-21), p. 21-27
    Type of Medium: Online Resource
    ISSN: 1753-3546 , 1753-3554
    Uniform Title: English
    URL: Issue
    Language: Unknown
    Publisher: Society of Glass Technology
    Publication Date: 2015
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  • 9
    Online Resource
    Online Resource
    Frontiers Media SA ; 2022
    In:  Frontiers in Pharmacology Vol. 13 ( 2022-11-23)
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-11-23)
    Abstract: Edible herbal medicines contain macro- and micronutrients and active metabolites that can take part in biochemical processes to help achieve or maintain a state of well-being. Citri Reticulatae Pericarpium (CRP) is an edible and medicinal herb used as a component of the traditional Chinese medicine (TCM) approach to treating COVID-19 in China. However, the material basis and related mechanistic research regarding this herb for the treatment of COVID-19 are still unclear. First, a wide-targeted UPLC-ESI-MS/MS-based comparative metabolomics analysis was conducted to screen for the active metabolites of CRP. Second, network pharmacology was used to uncover the initial linkages among these metabolites, their possible targets, and COVID-19. Each metabolite was then further studied via molecular docking with the identified potential SARS-CoV-2 targets 3CL hydrolase, host cell target angiotensin-converting enzyme II, spike protein, and RNA-dependent RNA polymerase. Finally, the most potential small molecule compound was verified by in vitro and in vivo experiments, and the mechanism of its treatment of COVID-19 was further explored. In total, 399 metabolites were identified and nine upregulated differential metabolites were screened out as potential key active metabolites, among which isorhamnetin have anti-inflammatory activity in vitro validation assays. In addition, the molecular docking results also showed that isorhamnetin had a good binding ability with the key targets of COVID-19. Furthermore, in vivo results showed that isorhamnetin could significantly reduced the lung pathological injury and inflammatory injury by regulating ATK1, EGFR, MAPK8, and MAPK14 to involve in TNF signaling pathway, PI3K-Akt signalling pathway, and T cell receptor signaling pathway. Our results indicated that isorhamnetin, as screened from CRP, may have great potential for use in the treatment of patients with COVID-19. This study has also demonstrated that comparative metabolomics combined with network pharmacology strategy could be used as an effective approach for discovering potential compounds in herbal medicines that are effective against COVID-19.
    Type of Medium: Online Resource
    ISSN: 1663-9812
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2587355-6
    SSG: 15,3
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  • 10
    Online Resource
    Online Resource
    American Meteorological Society ; 2022
    In:  Weather, Climate, and Society Vol. 14, No. 4 ( 2022-10), p. 1107-1118
    In: Weather, Climate, and Society, American Meteorological Society, Vol. 14, No. 4 ( 2022-10), p. 1107-1118
    Abstract: Although many studies have linked complex social processes with climate change, few have examined the connections between changes in environmental factors, resources, or energy and the evolution of civilizations on the Tibetan Plateau. The Chiefdom of Lijiang was a powerful chiefdom located on the eastern Tibetan Plateau during the Ming Dynasty; it began expanding after the 1460s. Although many studies have analyzed the political and economic motivations responsible for this expansion, no high-resolution climate records representing this period of the Chiefdom of Lijiang were available until now. Here, we obtain a 621-yr reconstruction of the April–July normalized difference vegetation index (NDVI) values derived from moisture-sensitive tree rings from the eastern Tibetan Plateau. Our NDVI reconstruction accounts for 40.4% of the variability in instrumentally measured NDVI values and can effectively represent the historical changes in regional vegetation productivity that occurred on the eastern Tibetan Plateau. In combination with a reconstruction of summer temperatures on the eastern Tibetan Plateau, these results reveal that the regional climate was relatively warm and persistently wet during the period 1466–1630. This period was characterized by long periods of above-mean vegetation productivity on the eastern Tibetan Plateau that coincided with the expansion of the Chiefdom of Lijiang. We therefore propose that the NDVI anomaly and associated favorable political environment may have affected the expansion of the Chiefdom of Lijiang. Instrumental climate data and tree rings also reveal that the early twenty-first-century drought on the eastern Tibetan Plateau was the hottest drought recorded over the past six centuries, in accordance with projections of warming over the Tibetan Plateau. Future climate warming may lead to the occurrence of similar droughts, with potentially severe consequences for modern Asia.
    Type of Medium: Online Resource
    ISSN: 1948-8327 , 1948-8335
    Language: Unknown
    Publisher: American Meteorological Society
    Publication Date: 2022
    detail.hit.zdb_id: 2628859-X
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