In:
Frontiers in Virology, Frontiers Media SA, Vol. 2 ( 2022-5-19)
Abstract:
HIV-1 reservoir size and dynamics are promising parameters to ensure the safe prescription of simplified maintenance antiretroviral therapy in chronically HIV-1 infected patients. In the SIMPL’HIV trial, HIV-1 DNA was quantified in peripheral blood mononuclear cells obtained at baseline and week 48 to investigate changes over time and evidence of a predictive relationship to maintain HIV-1 RNA & lt;20 copies/ml. Measurements were available for 175 patients, with no differences observed between treatment strategies. Findings showed that baseline HIV-1 DNA was lower in those with durable HIV-1 RNA & lt;20 copies/ml compared with patients with incomplete viral suppression over 48 weeks.
Type of Medium:
Online Resource
ISSN:
2673-818X
DOI:
10.3389/fviro.2022.855437
DOI:
10.3389/fviro.2022.855437.s001
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
3100943-8
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