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  • 1
    Online Resource
    Online Resource
    Reconceptualizing family caregivers as part of the health care team
    AME Publishing Company ; 2022
    In:  Journal of Hospital Management and Health Policy Vol. 6 ( 2022-6), p. 20-20
    Details
    In: Journal of Hospital Management and Health Policy, AME Publishing Company, Vol. 6 ( 2022-6), p. 20-20
    Type of Medium: Online Resource
    ISSN: 2523-2533
    URL: Journal
    URL: Article
    DOI: 10.21037/jhmhp
    DOI: 10.21037/jhmhp-21-56
    Language: Unknown
    Publisher: AME Publishing Company
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    COVID-19 and primary care physicians: adapting to rapid change in clinical roles and settings
    AME Publishing Company ; 2020
    In:  Journal of Hospital Management and Health Policy Vol. 4 ( 2020-12), p. 31-31
    Details
    In: Journal of Hospital Management and Health Policy, AME Publishing Company, Vol. 4 ( 2020-12), p. 31-31
    Type of Medium: Online Resource
    ISSN: 2523-2533
    URL: Journal
    URL: Article
    DOI: 10.21037/jhmhp
    DOI: 10.21037/jhmhp-20-130
    Language: Unknown
    Publisher: AME Publishing Company
    Publication Date: 2020
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  • 3
    Online Resource
    Online Resource
    Table_2.XLSX
    Frontiers Media SA ; 2023
    In:  Frontiers in Neuroscience Vol. 17 ( 2023-6-23)
    Details
    In: Frontiers in Neuroscience, Frontiers Media SA, Vol. 17 ( 2023-6-23)
    Abstract: Alpha 7 nicotinic acetylcholine receptor (α7nAChR) agonists have been developed to treat schizophrenia but failed in clinical trials due to rapid desensitization. GAT107, a type 2 allosteric agonist-positive allosteric modulator (ago-PAM) to the α7 nAChR was designed to activate the α7 nAChR while reducing desensitization. We hypothesized GAT107 would alter the activity of thalamocortical neural circuitry associated with cognition, emotion, and sensory perception. Methods The present study used pharmacological magnetic resonance imaging (phMRI) to evaluate the dose-dependent effect of GAT107 on brain activity in awake male rats. Rats were given a vehicle or one of three different doses of GAT107 (1, 3, and 10 mg/kg) during a 35 min scanning session. Changes in BOLD signal and resting state functional connectivity were evaluated and analyzed using a rat 3D MRI atlas with 173 brain areas. Results GAT107 presented with an inverted-U dose response curve with the 3 mg/kg dose having the greatest effect on the positive BOLD volume of activation. The primary somatosensory cortex, prefrontal cortex, thalamus, and basal ganglia, particularly areas with efferent connections from the midbrain dopaminergic system were activated as compared to vehicle. The hippocampus, hypothalamus, amygdala, brainstem, and cerebellum showed little activation. Forty-five min post treatment with GAT107, data for resting state functional connectivity were acquired and showed a global decrease in connectivity as compared to vehicle. Discussion GAT107 activated specific brain regions involved in cognitive control, motivation, and sensory perception using a BOLD provocation imaging protocol. However, when analyzed for resting state functional connectivity there was an inexplicable, general decrease in connectivity across all brain areas.
    Type of Medium: Online Resource
    ISSN: 1662-453X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fnins.2023.1196786
    DOI: 10.3389/fnins.2023.1196786.s001
    DOI: 10.3389/fnins.2023.1196786.s002
    DOI: 10.3389/fnins.2023.1196786.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2411902-7
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  • 4
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    Online Resource
    The Impact of Oral Health Training for Primary Care Clinicians: A Systematic Review
    Society of Teachers of Family Medicine ; 2019
    In:  Family Medicine Vol. 51, No. 3 ( 2019-3-1), p. 251-261
    Details
    In: Family Medicine, Society of Teachers of Family Medicine, Vol. 51, No. 3 ( 2019-3-1), p. 251-261
    Abstract: Background and Objectives: Despite recent improvements in access to health care, many Americans still lack access to dental care. There has been a national focus on interprofessional education and team-based care to work toward the integration of services including dental care into primary care. The purpose of this systematic review is to understand the impact of implementing oral health curricula in primary care training on measurable changes in primary care practice. Methods: Researchers utilized a two-step process, first a scoping review and then using the PRISMA systematic review method to develop inclusion and exclusion criteria around audience, curricula, and outcomes to identify practice change due to oral health education curricula delivered in primary care clinician training. Researchers assessed titles, abstracts, and full texts and abstracted data for the review. Results: Researchers reviewed 2,749 articles and found 12 meeting the systematic review criteria. The reported outcomes and evaluations differed for each of the 12 studies identified. Over 40% utilized self-reporting. Seven of the included studies tracked outcomes by checklists embedded in electronic health records changes to well-child visit forms, or chart audits, one of which also tracked billing reimbursements. Conclusions: Oral health curricula for primary care clinicians are too heterogeneous to determine the effects on practice behavior. Future research should focus on developing a clear evaluation framework for measuring practice level changes in primary care settings as a result of implementing an oral health curriculum.
    Type of Medium: Online Resource
    ISSN: 0742-3225
    URL: Article
    DOI: 10.22454/FamMed.2019.232634
    RVK:
    XA 42830
    Language: Unknown
    Publisher: Society of Teachers of Family Medicine
    Publication Date: 2019
    detail.hit.zdb_id: 2128318-7
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  • 5
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    The James Webb Space Telescope Mission
    IOP Publishing ; 2023
    In:  Publications of the Astronomical Society of the Pacific Vol. 135, No. 1048 ( 2023-06-01), p. 068001-
    Details
    In: Publications of the Astronomical Society of the Pacific, IOP Publishing, Vol. 135, No. 1048 ( 2023-06-01), p. 068001-
    Abstract: Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least 4 m. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the 6.5 m James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 yr, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.
    Type of Medium: Online Resource
    ISSN: 0004-6280 , 1538-3873
    URL: Article
    DOI: 10.1088/1538-3873/acd1b5
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2023
    detail.hit.zdb_id: 2003100-2
    detail.hit.zdb_id: 2207655-4
    SSG: 16,12
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  • 6
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    LSST: From Science Drivers to Reference Design and Anticipated Data Products
    American Astronomical Society ; 2019
    In:  The Astrophysical Journal Vol. 873, No. 2 ( 2019-03-11), p. 111-
    Details
    In: The Astrophysical Journal, American Astronomical Society, Vol. 873, No. 2 ( 2019-03-11), p. 111-
    Type of Medium: Online Resource
    ISSN: 1538-4357
    URL: Article
    DOI: 10.3847/1538-4357/ab042c
    Language: Unknown
    Publisher: American Astronomical Society
    Publication Date: 2019
    detail.hit.zdb_id: 2207648-7
    detail.hit.zdb_id: 1473835-1
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  • 7
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    DataSheet6.xlsx
    Frontiers Media SA ; 2023
    In:  Frontiers in Genetics Vol. 14 ( 2023-1-19)
    Details
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 14 ( 2023-1-19)
    Abstract: Disease tolerance, a host’s ability to limit damage from a given parasite burden, is quantified by the relationship between pathogen load and host survival or reproduction. Dermo disease, caused by the protozoan parasite P. marinus , negatively impacts survival in both wild and cultured eastern oyster ( C. virginica ) populations. Resistance to P. marinus has been the focus of previous studies, but tolerance also has important consequences for disease management in cultured and wild populations. In this study we measured dermo tolerance and evaluated global expression patterns of two sensitive and two tolerant eastern oyster families experimentally challenged with distinct doses of P. marinus (0, 10 6 , 10 7 , and 10 8 parasite spores per gram wet weight, n = 3–5 individuals per family per dose). Weighted Gene Correlation Network Analysis (WGCNA) identified several modules correlated with increasing parasite dose/infection intensity, as well as phenotype. Modules positively correlated with dose included transcripts and enriched GO terms related to hemocyte activation and cell cycle activity. Additionally, these modules included G-protein coupled receptor, toll-like receptor, and tumor necrosis factor pathways, which are important for immune effector molecule and apoptosis activation. Increased metabolic activity was also positively correlated with treatment. The module negatively correlated with infection intensity was enriched with GO terms associated with normal cellular activity and growth, indicating a trade-off with increased immune response. The module positively correlated with the tolerant phenotype was enriched for transcripts associated with “programmed cell death” and contained a large number of tripartite motif-containing proteins. Differential expression analysis was also performed on the 10 8 dosed group using the most sensitive family as the comparison reference. Results were consistent with the network analysis, but signals for “programmed cell death” and serine protease inhibitors were stronger in one tolerant family than the other, suggesting that there are multiple avenues for disease tolerance. These results provide new insight for defining dermo response traits and have important implications for applying selective breeding for disease management.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fgene.2023.1054558
    DOI: 10.3389/fgene.2023.1054558.s001
    DOI: 10.3389/fgene.2023.1054558.s002
    DOI: 10.3389/fgene.2023.1054558.s003
    DOI: 10.3389/fgene.2023.1054558.s004
    DOI: 10.3389/fgene.2023.1054558.s005
    DOI: 10.3389/fgene.2023.1054558.s006
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2023
    detail.hit.zdb_id: 2606823-0
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  • 8
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    Image1.png
    Frontiers Media SA ; 2022
    In:  Frontiers in Genetics Vol. 12 ( 2022-2-3)
    Details
    In: Frontiers in Genetics, Frontiers Media SA, Vol. 12 ( 2022-2-3)
    Abstract: Health Interpreters enable effective communication between health practitioners and patients with limited knowledge of the predominant language. This study developed and evaluated a training session introducing Health Interpreters to genetics. The online training was delivered multiple times as a single 2-h session comprising lectures and activities. Participants completed questionnaires (pre-, post-, and 6-months follow-up) to assess the impact of training on knowledge, attitude, self-efficacy, and self-reported practice behaviour. Questionnaires were analysed using descriptive statistics, Fisher’s Exact, or independent t -test. In total, 118 interpreters participated in the training sessions. Respondent knowledge improved, with gains maintained at 6-months ( p & lt; 0.01). There were no changes in self-efficacy, and attitudes. Training did not change self-reported practice behaviour, but there was notable pre-existing variability in participants’ methods of managing unknown genetic words. Most respondents agreed that training was useful (93%) and relevant (79%) to their work. More respondents reported learning more from the case study activity (86%) than the group activity (58%). Health Interpreters found the training acceptable and demonstrated sustained improvement in knowledge of genetic concepts. Increased delivery of this training and associated research is needed to assess findings in a larger cohort and to measure the impact on patients.
    Type of Medium: Online Resource
    ISSN: 1664-8021
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fgene.2021.771892
    DOI: 10.3389/fgene.2021.771892.s001
    DOI: 10.3389/fgene.2021.771892.s002
    DOI: 10.3389/fgene.2021.771892.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2606823-0
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  • 9
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    Online Resource
    A machine learning approach to predict early outcomes after pituitary adenoma surgery
    Journal of Neurosurgery Publishing Group (JNSPG) ; 2018
    In:  Neurosurgical Focus Vol. 45, No. 5 ( 2018-11), p. E8-
    Details
    In: Neurosurgical Focus, Journal of Neurosurgery Publishing Group (JNSPG), Vol. 45, No. 5 ( 2018-11), p. E8-
    Abstract: Pituitary adenomas occur in a heterogeneous patient population with diverse perioperative risk factors, endocrinopathies, and other tumor-related comorbidities. This heterogeneity makes predicting postoperative outcomes challenging when using traditional scoring systems. Modern machine learning algorithms can automatically identify the most predictive risk factors and learn complex risk-factor interactions using training data to build a robust predictive model that can generalize to new patient cohorts. The authors sought to build a predictive model using supervised machine learning to accurately predict early outcomes of pituitary adenoma surgery. METHODS A retrospective cohort of 400 consecutive pituitary adenoma patients was used. Patient variables/predictive features were limited to common patient characteristics to improve model implementation. Univariate and multivariate odds ratio analysis was performed to identify individual risk factors for common postoperative complications and to compare risk factors with model predictors. The study population was split into 300 training/validation patients and 100 testing patients to train and evaluate four machine learning models using binary classification accuracy for predicting early outcomes. RESULTS The study included a total of 400 patients. The mean ± SD patient age was 53.9 ± 16.3 years, 59.8% of patients had nonfunctioning adenomas and 84.7% had macroadenomas, and the mean body mass index (BMI) was 32.6 ± 7.8 (58.0% obesity rate). Multivariate odds ratio analysis demonstrated that age 〈 40 years was associated with a 2.86 greater odds of postoperative diabetes insipidus and that nonobese patients (BMI 〈 30) were 2.2 times more likely to develop postoperative hyponatremia. Using broad criteria for a poor early postoperative outcome—major medical and early surgical complications, extended length of stay, emergency department admission, inpatient readmission, and death—31.0% of patients met criteria for a poor early outcome. After model training, a logistic regression model with elastic net (LR-EN) regularization best predicted early postoperative outcomes of pituitary adenoma surgery on the 100-patient testing set—sensitivity 68.0%, specificity 93.3%, overall accuracy 87.0%. The receiver operating characteristic and precision-recall curves for the LR-EN model had areas under the curve of 82.7 and 69.5, respectively. The most important predictive variables were lowest perioperative sodium, age, BMI, highest perioperative sodium, and Cushing’s disease. CONCLUSIONS Early postoperative outcomes of pituitary adenoma surgery can be predicted with 87% accuracy using a machine learning approach. These results provide insight into how predictive modeling using machine learning can be used to improve the perioperative management of pituitary adenoma patients.
    Type of Medium: Online Resource
    ISSN: 1092-0684
    URL: Article
    DOI: 10.3171/2018.8.FOCUS18268
    Language: Unknown
    Publisher: Journal of Neurosurgery Publishing Group (JNSPG)
    Publication Date: 2018
    detail.hit.zdb_id: 2026589-X
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  • 10
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    A physical simulator for endoscopic endonasal drilling techniques: technical note
    Journal of Neurosurgery Publishing Group (JNSPG) ; 2016
    In:  Journal of Neurosurgery Vol. 124, No. 3 ( 2016-03), p. 811-816
    Details
    In: Journal of Neurosurgery, Journal of Neurosurgery Publishing Group (JNSPG), Vol. 124, No. 3 ( 2016-03), p. 811-816
    Abstract: In this paper, the authors present a physical model developed to teach surgeons the requisite drilling techniques when using an endoscopic endonasal approach (EEA) to the skull base. EEA is increasingly used for treating pathologies of the ventral and ventrolateral cranial base. Endonasal drilling is a unique skill in terms of the instruments used, the long reach required, and the restricted angulation, and gaining competency requires much practice. Based on the successful experience in creating custom simulators, the authors used 3D printing to build an EEA training model from post-processed thin-cut head CT scans, formulating the materials to provide realistic haptic feedback and endoscope handling. They performed a preliminary assessment at 2 institutions to evaluate content validity of the simulator as the first step of the validation process. Overall results were positive, particularly in terms of bony landmarks and haptic response, though minor refinements were suggested prior to use as a training device.
    Type of Medium: Online Resource
    ISSN: 0022-3085 , 1933-0693
    URL: Article
    DOI: 10.3171/2015.3.JNS1552
    RVK:
    XA 10000
    RVK:
    XA 55270
    Language: Unknown
    Publisher: Journal of Neurosurgery Publishing Group (JNSPG)
    Publication Date: 2016
    detail.hit.zdb_id: 2026156-1
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