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  • Online Resource  (3)
  • Paediatrician Publishers LLC  (3)
  • Unknown  (3)
  • 2015-2019  (3)
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  • Online Resource  (3)
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  • Paediatrician Publishers LLC  (3)
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  • Unknown  (3)
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  • 2015-2019  (3)
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  • 1
    Online Resource
    Online Resource
    А Study of the Amount of CD57+ Cytotoxic T-lymphocytes in Bone Marrow associated with the Development of Small Round Cell Sarcomas in Children: A Retrospective Cohort Study
    Paediatrician Publishers LLC ; 2018
    In:  Oncopediatrics Vol. 5, No. 1 ( 2018-04-20), p. 32-40
    Details
    In: Oncopediatrics, Paediatrician Publishers LLC, Vol. 5, No. 1 ( 2018-04-20), p. 32-40
    Abstract: Background. There is little data on the number of CD57+ cytotoxic T-lymphocytes (CTL) in the bone marrow of healthy children and children with developing small round cell sarcomas (rhabdomyosarcoma and Ewing`s sarcoma). Objective. Our aim was to study the amount of CD57 + CTL in bone marrow of children with developing small round cell sarcomas. Methods. A retrospective cohort analysis was conducted for the period of 2006–2011. It enrolled 47 patients aged 1–17 y.o. (mean age — 8.6 years) who underwent the bone marrow aspiration; the examination results were studied with morphological and immunocytometric method. The obtained mean values of CD57+ T-cell were processed by the statistical program SPSS17. Results. Rhabdomyosarcoma (RMS) was diagnosed in 16 patients, Ewing`s sarcoma (ES) — in 16 patients. The control group included 15 patients with no malignant tumours. In patients with ES, higher percent of CD3+CD57+ (p=0.022) and CD8+CD57+ (p=0.028) subpopulations was registered. The percentage and absolute level of CD3+CD57+ and CD8+CD57+ T-cells in the bone marrow of patients with RMS did not differ from the control (p=0.125 and р=0.181 respectively). Comparison of percentage of CD3+CD57+ and CD8+CD57+ T-lymphocyte subpopulations in subjects of both groups revealed no differences (р=0.091 and р=0.060 respectively). We registered higher amount of CD3+CD57+ and CD8+CD57+ T-cell subpopulations in patients with ES than in patients with RMS (p=0.009 and p=0.014 respectively). Conclusion. Each malignant disease when diagnosing is characterized by specific changes in the patterns of CD57 + CTL subpopulations derived from the bone marrow which allows to reveal its clinical and prognostic significance, understand better the mechanisms of interaction between the tumor and the immune system, and serve for the development of immunotherapy programs.
    Type of Medium: Online Resource
    ISSN: 2311-9977
    URL: Article
    DOI: 10.15690/onco.v5i1.1864
    Language: Unknown
    Publisher: Paediatrician Publishers LLC
    Publication Date: 2018
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    Online Resource
  • 2
    Online Resource
    Online Resource
    Prevalence and Clinical Laboratory Features of Cryptosporidiosis in Children under 5 Years of Age: A Cross-Sectional Study of Hospital Cases of Acute Intestinal Infection
    Paediatrician Publishers LLC ; 2018
    In:  Current pediatrics Vol. 17, No. 4 ( 2018-10-05), p. 316-321
    Details
    In: Current pediatrics, Paediatrician Publishers LLC, Vol. 17, No. 4 ( 2018-10-05), p. 316-321
    Abstract: Background. Cryptosporidium protozoa are the leading causative agent of diarrhea and cause of death in children under 5 years of age. The role of cryptosporidia in the development and course of acute intestinal infections (AII) in children in Russia remains unstudied. Objective. Our aim was to study the prevalence and clinical laboratory features of cryptosporidium-associated aII in children under 5 years of age. Methods. A cross-sectional study (conducted in March-June 2017) included children admitted to hospital with symptoms of AII (fever, loose watery stools, weakness, decreased appetite and/or vomiting) by the ambulance service. On admission, stool samples were collected from all patients. Cryptosporidium oocysts were determined by microscopic examination of faecal smears stained according to Tsil-Nielsen after preliminary concentration by a modified formalin-ether technique. The presence of intestinal pathogens was determined by a bacteriological technique and using a polymerase chain reaction. Results. The study included 107 children with AII (girls — 51%). Cryptosporidia were detected in 28 (26%) patients, in 93% of cases — together with bacterial and/or viral pathogens. The etiological structure of cryptosporidium-associated AII and AII in cryptosporidiosis negative children (n = 79) did not differ. On admission, children with cryptosporidium-associated AII had a higher blood leukocyte count — 13.0_109/L (9.2; 16.0) versus 8.3_109/L (6.1; 11.2) in children without cryptosporidiosis (p 〈 0.001). It has been also found that antibiotics were more often used in the treatment of children with cryptosporidium-associated AII — in 21 (75%) versus 39 (49%) in the comparison group (p = 0.026). Conclusion. Cryptosporidia are detected in every fourth child with AII under 5 years of age. Patients with cryptosporidia are distinguished by a higher level of blood leukocytes upon admission and a more frequent prescription of antibiotics than in the group of cryptosporidiosis negative patients.
    Type of Medium: Online Resource
    ISSN: 1682-5535 , 1682-5527
    URL: Article
    DOI: 10.15690/vsp.v17i4.1925
    Language: Unknown
    Publisher: Paediatrician Publishers LLC
    Publication Date: 2018
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    Online Resource
  • 3
    Online Resource
    Online Resource
    Angiodysplasia Combined with Thymic Aplasia in an Infant: A Rare Clinical Case
    Paediatrician Publishers LLC ; 2018
    In:  Current pediatrics Vol. 17, No. 4 ( 2018-10-05), p. 333-340
    Details
    In: Current pediatrics, Paediatrician Publishers LLC, Vol. 17, No. 4 ( 2018-10-05), p. 333-340
    Abstract: Background. The prevalence of congenital malformations of the vessels or angiodysplasia ranges from 1:50,000 to 1:5,000,000. Congenital angiodysplasia is a consequence of impaired formation and development of the vascular system in embryogenesis. The aetiology of angiodysplasia remains poorly studied, and the diagnosis involves significant difficulties in some cases. Clinical Case Description. The observation of a rare case of a combined malformation of vessels and thymic aplasia in a female infant is presented. Angiodysplasia included the syndrome of congenital generalised phlebectasia (synonym: congenital telangiectatic marbled skin) combined with multiple vascular malformations with predominant vascular lesions of the brain, lungs, heart, kidneys, and mesentery. Clinically, the disease was characterised by a generalised change in the skin in the form of livedo reticularis accompanied by the development of severe pneumonia, persistent urinary syndrome, neurological symptoms (convulsive seizures, motor disorders), and progressive heart failure. The diagnosis was confirmed in the course of a pathological study. Conclusion. The presented case allows expanding the notion of the variety of clinical manifestations of congenital angiodysplasia, as well as its possible combinations with other malformations.
    Type of Medium: Online Resource
    ISSN: 1682-5535 , 1682-5527
    URL: Article
    DOI: 10.15690/vsp.v17i4.1928
    Language: Unknown
    Publisher: Paediatrician Publishers LLC
    Publication Date: 2018
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    Online Resource
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