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  • 1
    Online-Ressource
    Online-Ressource
    Wiley ; 2016
    In:  British Journal of Clinical Pharmacology Vol. 81, No. 3 ( 2016-03), p. 446-452
    In: British Journal of Clinical Pharmacology, Wiley, Vol. 81, No. 3 ( 2016-03), p. 446-452
    Kurzfassung: Antivenom is the mainstay of treatment of snakebite envenoming. However, adverse reactions to snake antivenom that is available are common in many parts of the world where snakebite is prevalent. Both acute (anaphylactic or pyrogenic) and delayed (serum sickness type) reactions occur. Acute reactions are usually mild but severe systemic anaphylaxis may develop, often within an hour or so of exposure to antivenom. Serum sickness after antivenom has a delayed onset between 5 and 14 days after its administration. Ultimately, the prevention reactions will depend mainly on improving the quality of antivenom. Until these overdue improvements take place, doctors will have to depend on pharmacological prophylaxis, where the search for the best prophylactic agent is still on‐going, as well as careful observation of patients receiving antivenom in preparation for prompt management of acute as well as delayed reactions when they occur.
    Materialart: Online-Ressource
    ISSN: 0306-5251 , 1365-2125
    URL: Issue
    RVK:
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2016
    ZDB Id: 1498142-7
    SSG: 15,3
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    In: Journal of Pharmacy Practice and Research, Wiley, Vol. 47, No. 2 ( 2017-04), p. 121-130
    Kurzfassung: Quality use of medicines ( QUM ) has been identified as a priority in Sri Lanka. Aim To identify opportunities to optimise QUM , and evaluate medication appropriateness and medication information exchanged with patients and carers on discharge in a Sri Lankan tertiary care hospital. Methods An observational, prospective, cohort study of patients systematically sampled from two medical wards. A research pharmacist determined their pre‐admission medication regimen via interview at time of discharge. Issues of poor adherence and discrepancies between the pre‐ and post‐admission medication regimens were recorded. Drug‐related problems were categorised into opportunities to optimise drug therapy. The appropriateness of discharge medications was evaluated using a validated tool. The patient or carer was interviewed after discharge regarding the quality of medicine information exchanged in hospital. Results The 578 recruited patients were taking 1756 medications prior to admission, and 657 (37.4%) of these medications were not continued during admission. Opportunities to optimise drug therapy were identified on 1496 occasions during admission (median, 2.0 opportunities/patient), 215 opportunities, (14.4%) were resolved spontaneously by the medical team prior to discharge. The median score for appropriateness of medications on discharge was 1.5 per patient (interquartile range, 0.0–3.5). Of 427 patients surveyed after discharge, 52% recalled being asked about their medications on admission to hospital, 75% about previous adverse medication reactions and 39% recalled being informed about changes to their medications on discharge. Conclusion Significant opportunities exist for pharmacists to enhance quality use of medicines for patients in the current hospital‐based healthcare system in Sri Lanka.
    Materialart: Online-Ressource
    ISSN: 1445-937X , 2055-2335
    URL: Issue
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2017
    ZDB Id: 2576048-8
    SSG: 15,3
    Standort Signatur Einschränkungen Verfügbarkeit
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