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  • 1
    Online Resource
    Online Resource
    Astaxanthin and Nrf2 Signaling Pathway: A Novel Target for New Therapeutic Approaches
    Bentham Science Publishers Ltd. ; 2022
    In:  Mini-Reviews in Medicinal Chemistry Vol. 22, No. 2 ( 2022-02), p. 312-321
    Details
    In: Mini-Reviews in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 22, No. 2 ( 2022-02), p. 312-321
    Abstract: Astaxanthin (AST) is a naturally occurring compound isolated from various sources such as fungi, plants, salmon, and crab. However, Haematococcus Pluvialis, a green alga, is the primary source of this beta carotenoid compound. AST has several favourable biological and pharmacological activities such as antioxidant, anti-inflammatory, anti-tumor, anti-diabetes, hepatoprotective, and neuroprotective activities. Nevertheless, the exact molecular mechanisms of these protective effects of AST are unclear yet. The Nrf2 signaling pathway is one of the critical candidate signaling pathways that may be involved in these beneficial effects of AST. This signaling pathway is responsible for maintaining the redox balance in the physiological state. Upon nuclear translocation, Nrf2 signaling activates antioxidant enzymes to reduce oxidative stress and protect cells against damage. In the current study, we have reviewed the effects of AST on the Nrf2 signaling pathway, which could potentially be developed as a novel therapeutic approach for the management of various diseases.
    Type of Medium: Online Resource
    ISSN: 1389-5575
    URL: Article
    DOI: 10.2174/1389557521666210505112834
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2022
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  • 2
    Online Resource
    Online Resource
    The Beneficial Effects of Curcumin on Lipids: Possible Effects on Dyslipidemia-Induced Cardiovascular Complications
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Medicinal Chemistry Vol. 31 ( 2023-07-07)
    Details
    In: Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 31 ( 2023-07-07)
    Abstract: Dyslipidemia and altered lipid metabolism are closely involved in the pathogenesis and clinical manifestation of many metabolic and non-metabolic diseases. Therefore, mitigation of pharmacological and nutritional factors together with lifestyle modifications is paramount. One potential nutraceutical exhibiting cell signaling and lipid-modulating properties implicated in dyslipidemias is curcumin. Specifically, recent evidence suggest that curcumin may improve lipid metabolism and prevent dyslipidemia-induced cardiovascular complications via several pathways. Although the exact molecular mechanisms involved are not well understood, the evidence presented in this review suggests that curcumin can provide significant lipid benefits via modulation of adipogenesis and lipolysis, and prevention or reduction of lipid peroxidation and lipotoxicity via different molecular pathways. Curcumin can also improve the lipid profile and reduce dyslipidemia-dependent cardiovascular problems by impacting important mechanisms of fatty acid oxidation, lipid absorption, and cholesterol metabolism. Although only limited direct supporting evidence is available, in this review we assess the available knowledge regarding the possible nutraceutical effects of curcumin on lipid homeostasis and its possible impacts on dyslipidemic cardiovascular events from a mechanistic viewpoint.
    Type of Medium: Online Resource
    ISSN: 0929-8673
    URL: Article
    DOI: 10.2174/0929867331666230707094644
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
    SSG: 15,3
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  • 3
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    Online Resource
    Curcumin Therapeutic Modulation of the Wnt Signaling Pathway
    Bentham Science Publishers Ltd. ; 2020
    In:  Current Pharmaceutical Biotechnology Vol. 21, No. 11 ( 2020-09-21), p. 1006-1015
    Details
    In: Current Pharmaceutical Biotechnology, Bentham Science Publishers Ltd., Vol. 21, No. 11 ( 2020-09-21), p. 1006-1015
    Abstract: Curcumin, isolated from the rhizome of Curcuma longa, is one of the most extensively studied phytochemicals. This natural compound has a variety of pharmacological effects including antioxidant, anti-inflammatory, anti-tumor, cardio-protective, hepato-protective and anti-diabetic. Wnt signaling pathway, one of the potential targets of curcumin through upregulation and/or downregulation, plays a significant role in many diseases, even in embryogenesis and development of various organs and systems. In order to exert an anti-tumor activity in the organism, curcumin seems to inhibit the Wnt pathway. The downstream mediators of Wnt signaling pathway such as c-Myc and cyclin D1 are also modified by curcumin. This review demonstrates how curcumin influences the Wnt signaling pathway and is beneficial for the treatment of neurological disorders (Alzheimer’s and Parkinson’s diseases), cancers (melanoma, lung cancer, breast cancer, colon cancer, endothelial carcinoma, gastric carcinoma and hepatocellular carcinoma) and other diseases, such as diabetes mellitus or bone disorders.
    Type of Medium: Online Resource
    ISSN: 1389-2010
    URL: Article
    DOI: 10.2174/1389201021666200305115101
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2020
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  • 4
    Online Resource
    Online Resource
    Therapeutic Effects of Curcumin against Bladder Cancer: A Review of Possible Molecular Pathways
    Bentham Science Publishers Ltd. ; 2020
    In:  Anti-Cancer Agents in Medicinal Chemistry Vol. 20, No. 6 ( 2020-06-14), p. 667-677
    Details
    In: Anti-Cancer Agents in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 20, No. 6 ( 2020-06-14), p. 667-677
    Abstract: There are concerns about the increased incidence of cancer both in developing and developed countries. In spite of recent progress in cancer therapy, this disease is still one of the leading causes of death worldwide. Consequently, there have been rigorous attempts to improve cancer therapy by looking at nature as a rich source of naturally occurring anti-tumor drugs. Curcumin is a well-known plant-derived polyphenol found in turmeric. This compound has numerous pharmacological effects such as antioxidant, anti-inflammatory, antidiabetic and anti-tumor properties. Curcumin is capable of suppressing the growth of a variety of cancer cells including those of bladder cancer. Given the involvement of various signaling pathways such as PI3K, Akt, mTOR and VEGF in the progression and malignancy of bladder cancer, and considering the potential of curcumin in targeting signaling pathways, it seems that curcumin can be considered as a promising candidate in bladder cancer therapy. In the present review, we describe the molecular signaling pathways through which curcumin inhibits invasion and metastasis of bladder cancer cells.
    Type of Medium: Online Resource
    ISSN: 1871-5206
    URL: Article
    DOI: 10.2174/1871520620666200203143803
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2020
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    Renal Effects of Empagliflozin in Patients with Type 2 Diabetes Mellitus
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Medicinal Chemistry Vol. 30, No. 25 ( 2023-08), p. 2850-2863
    Details
    In: Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 30, No. 25 ( 2023-08), p. 2850-2863
    Abstract: Type 2 diabetes mellitus (T2DM) is one of the main causes of mortality and morbidity worldwide. It leads to various long-term complications such as diabetic nephropathy. Diabetes nephropathy is the leading cause of renal failure in patients with chronic kidney diseases undergoing hemodialysis. Hence preventing the development and progression of diabetic nephropathy is one of the main goals in the management of patients with type 2 diabetes. Sodium-glucose cotransporter 2 inhibitors of empagliflozin is a potent anti-hyperglycemic agents. In addition, it has been shown to have some pharmacologic potentials to provide renoprotective effects in patients with T2DM. In the current study, we review the available clinical data on the potential renoprotective effects of this drug from a mechanistic and molecular viewpoint.
    Type of Medium: Online Resource
    ISSN: 0929-8673
    URL: Article
    DOI: 10.2174/0929867329666220831151645
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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  • 6
    Online Resource
    Online Resource
    Neuromodulatory effects of anti-diabetes medications: A mechanistic review
    Elsevier BV ; 2020
    In:  Pharmacological Research Vol. 152 ( 2020-02), p. 104611-
    Details
    In: Pharmacological Research, Elsevier BV, Vol. 152 ( 2020-02), p. 104611-
    Type of Medium: Online Resource
    ISSN: 1043-6618
    URL: Article
    DOI: 10.1016/j.phrs.2019.104611
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 1471456-5
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Benefits of GLP-1 Mimetics on Epicardial Adiposity
    Bentham Science Publishers Ltd. ; 2023
    In:  Current Medicinal Chemistry Vol. 30, No. 37 ( 2023-11), p. 4256-4265
    Details
    In: Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 30, No. 37 ( 2023-11), p. 4256-4265
    Abstract: The epicardial adipose tissue, which is referred to as fats surrounding the myocardium, is an active organ able to induce cardiovascular problems in pathophysiologic conditions through several pathways, such as inflammation, fibrosis, fat infiltration, and electrophysiologic problems. So, control of its volume and thickness, especially in patients with diabetes, is highly important. Incretin-based pharmacologic agents are newly developed antidiabetics that could provide further cardiovascular benefits through control and modulating epicardial adiposity. They can reduce cardiovascular risks by rapidly reducing epicardial adipose tissues, improving cardiac efficiency. We are at the first steps of a long way, but current evidence demonstrates the sum of possible mechanisms. In this study, we evaluate epicardial adiposity in physiologic and pathologic states and the impact of incretin-based drugs.
    Type of Medium: Online Resource
    ISSN: 0929-8673
    URL: Article
    DOI: 10.2174/0929867330666230113110431
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2023
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  • 8
    Online Resource
    Online Resource
    Anti-Tumor Effects of Osthole on Different Malignant Tissues: A Review of Molecular Mechanisms
    Bentham Science Publishers Ltd. ; 2020
    In:  Anti-Cancer Agents in Medicinal Chemistry Vol. 20, No. 8 ( 2020-07-24), p. 918-931
    Details
    In: Anti-Cancer Agents in Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 20, No. 8 ( 2020-07-24), p. 918-931
    Abstract: Cancer management and/or treatment require a comprehensive understanding of the molecular and signaling pathways involved. Recently, much attention has been directed to these molecular and signaling pathways, and it has been suggested that a number of biomolecules/players involved in such pathways, such as PI3K/Akt, NF- & #954;B, STAT, and Nrf2 contribute to the progression, invasion, proliferation, and metastasis of malignant cells. Synthetic anti-tumor agents and chemotherapeutic drugs have been a mainstay in cancer therapy and are widely used to suppress the progression and, hopefully, halt the proliferation of malignant cells. However, these agents have some undesirable side-effects and, therefore, naturally-occurring compounds with high potency and fewer side-effects are now of great interest. Osthole is a plant-derived chemical compound that can inhibit the proliferation of malignant cells and provide potent anti-cancer effects in various tissues. Therefore, in this review, we presented the main findings concerning the potential anti-tumor effects of osthole and its derivatives and described possible molecular mechanisms by which osthole may suppress malignant cell proliferation in different tissues.
    Type of Medium: Online Resource
    ISSN: 1871-5206
    URL: Article
    DOI: 10.2174/1871520620666200228110704
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2020
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  • 9
    Online Resource
    Online Resource
    Crocin Improves Oxidative Stress by Potentiating Intrinsic Anti-Oxidant Defense Systems in Pancreatic Cells During Uncontrolled Hyperglycemia
    Korean Pharmacopuncture Institute ; 2019
    In:  Journal of Pharmacopuncture Vol. 22, No. 2 ( 2019-06-30), p. 83-89
    Details
    In: Journal of Pharmacopuncture, Korean Pharmacopuncture Institute, Vol. 22, No. 2 ( 2019-06-30), p. 83-89
    Type of Medium: Online Resource
    ISSN: 2093-6966 , 2234-6856
    URL: Article
    DOI: 10.3831/KPI.2019.22.010
    Language: English
    Publisher: Korean Pharmacopuncture Institute
    Publication Date: 2019
    detail.hit.zdb_id: 2747301-6
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  • 10
    Online Resource
    Online Resource
    Cognitive Benefits of Sodium-Glucose Co-Transporters-2 Inhibitors in the Diabetic Milieu
    Bentham Science Publishers Ltd. ; 2024
    In:  Current Medicinal Chemistry Vol. 31, No. 2 ( 2024-01), p. 138-151
    Details
    In: Current Medicinal Chemistry, Bentham Science Publishers Ltd., Vol. 31, No. 2 ( 2024-01), p. 138-151
    Abstract: Patients with diabetes are at higher risk of cognitive impairment and memory loss than the normal population. Thus, using hypoglycemic agents to improve brain function is important for diabetic patients. Sodium-glucose cotransporters-2 inhibitors (SGLT2i) are a class of therapeutic agents used in the management of diabetes that has some pharmacologic effects enabling them to fight against the onset and progress of memory deficits. Although the exact mediating pathways are not well understood, emerging evidence suggests that SGLT2 inhibition is associated with improved brain function. This study reviewed the possible mechanisms and provided evidence suggesting SGLT2 inhibitors could ameliorate cognitive deficits.
    Type of Medium: Online Resource
    ISSN: 0929-8673
    URL: Article
    DOI: 10.2174/0929867330666230202163513
    Language: English
    Publisher: Bentham Science Publishers Ltd.
    Publication Date: 2024
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