In:
Clinical Pharmacology & Therapeutics, Wiley, Vol. 108, No. 6 ( 2020-12), p. 1185-1194
Abstract:
This study aimed to investigate whether specific medications used in the treatment chronic diseases affected either the development and/ or severity of coronavirus disease 2019 (COVID‐19) in a cohort of 610 COVID‐19 cases and 48,667 population‐based controls from Zhejiang, China. Using a cohort of 578 COVID‐19 cases and 48,667 population‐based controls from Zhejiang, China, we tested the role of usage of cardiovascular, antidiabetic, and other medications on risk and severity of COVID‐19. Analyses were adjusted for age, sex, and body mass index and for presence of relevant comorbidities. Individuals with hypertension taking calcium channel blockers had significantly increased risk (odds ratio (OR) = 1.73, 95% confidence interval (CI) 1.2–2.3) of manifesting symptoms of COVID‐19, whereas those taking angiotensin receptor blockers and diuretics had significantly lower disease risk (OR = 0.22, 95% CI 0.15–0.30 and OR = 0.30, 95% CI 0.19–0.58, respectively). Among those with type 2 diabetes, dipeptidyl peptidase‐4 inhibitors (OR = 6.02, 95% CI 2.3–15.5) and insulin (OR = 2.71, 95% CI 1.6–5.5) were more and glucosidase inhibitors were less prevalent (OR = 0.11, 95% CI 0.1–0.3) among with patients with COVID‐19. Drugs used in the treatment of hypertension and diabetes influence the risk of development of COVID‐19, but, not its severity.
Type of Medium:
Online Resource
ISSN:
0009-9236
,
1532-6535
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
2040184-X
SSG:
15,3
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