In:
Antioxidants, MDPI AG, Vol. 11, No. 11 ( 2022-11-01), p. 2172-
Abstract:
The radiation-induced bystander effect (RIBE), an important non-targeted effect of radiation, has been proposed to be associated with irradiation-caused secondary cancers and reproductive damage beyond the irradiation-treated area after radiotherapy. However, the mechanisms for RIBE signal(s) regulation and transduction are not well understood. In the present work, we found that a Golgi protein, GOLPH3, was involved in RIBE transduction. Knocking down GOLPH3 in irradiated cells blocked the generation of the RIBE, whereas re-expression of GOLPH3 in knockdown cells rescued the RIBE. Furthermore, TNF-α was identified as an important intercellular signal molecule in the GOLPH3-mediated RIBE. A novel signal axis, GOLPH3/ERK/EGR1, was discovered to modulate the transcription of TNF-α and determine the level of released TNF-α. Our findings provide new insights into the molecular mechanism of the RIBE and a potential target for RIBE modulation.
Type of Medium:
Online Resource
ISSN:
2076-3921
DOI:
10.3390/antiox11112172
Language:
English
Publisher:
MDPI AG
Publication Date:
2022
detail.hit.zdb_id:
2704216-9
SSG:
15,3
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